FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999648799> ?p ?o ?g. }

• W2999648799 endingPage "6" @default.
• W2999648799 startingPage "1" @default.
• W2999648799 abstract "Inflammatory bowel disease (IBD) consists of two major idiopathic gastrointestinal diseases: ulcerative colitis and Crohn's disease. Although a significant advance has been achieved in the treatment of IBD, there remains a particular population of patients that are refractory to the conventional treatments, including the biologic agents. Studies have revealed the importance of mucosal healing in improving the prognosis of those difficult-to-treat patients, which indicates the proper and complete regeneration of the damaged intestinal tissue. In this regard, organoid-based regenerative medicine may have the potential to dramatically promote the achievement of mucosal healing in refractory IBD patients, and thereby improve their long-term prognosis as well. So far, studies have shown that hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) may have some beneficial effect on IBD patients through their transplantation or transfusion. Recent advance in stem cell biology has added intestinal stem cells (ISCs) as a new player in this field. It has been shown that ISCs can be grown in vitro as organoids and that those ex-vivo cultured organoids can be employed as donor cells for transplantation studies. Further studies using mice colitis models have shown that ex-vivo cultured organoids can engraft onto the colitic ulcers and reconstruct the crypt-villus structures. Such transplantation of organoids may not only facilitate the regeneration of the refractory ulcers that may persist in IBD patients but may also reduce the risk of developing colitis-associated cancers. Endoscopy-assisted transplantation of organoids may, therefore, become one of the alternative therapies for refractory IBD patients." @default.
• W2999648799 created "2020-01-23" @default.
• W2999648799 creator A5009454728 @default.
• W2999648799 creator A5016653415 @default.
• W2999648799 creator A5033997049 @default.
• W2999648799 creator A5045376146 @default.
• W2999648799 creator A5051458435 @default.
• W2999648799 creator A5051595442 @default.
• W2999648799 creator A5052288893 @default.
• W2999648799 creator A5053241809 @default.
• W2999648799 creator A5064241594 @default.
• W2999648799 creator A5068715003 @default.
• W2999648799 creator A5076002314 @default.
• W2999648799 creator A5076538361 @default.
• W2999648799 date "2020-03-01" @default.
• W2999648799 modified "2023-10-17" @default.
• W2999648799 title "Organoid-based regenerative medicine for inflammatory bowel disease" @default.
• W2999648799 cites W1483496013 @default.
• W2999648799 cites W1532981600 @default.
• W2999648799 cites W1536414479 @default.
• W2999648799 cites W1574718766 @default.
• W2999648799 cites W1576969365 @default.
• W2999648799 cites W1872124954 @default.
• W2999648799 cites W1910349427 @default.
• W2999648799 cites W1965157206 @default.
• W2999648799 cites W1967091196 @default.
• W2999648799 cites W1976652533 @default.
• W2999648799 cites W1982603620 @default.
• W2999648799 cites W1986406665 @default.
• W2999648799 cites W1997114875 @default.
• W2999648799 cites W1997280251 @default.
• W2999648799 cites W2002513358 @default.
• W2999648799 cites W2023351030 @default.
• W2999648799 cites W2024121629 @default.
• W2999648799 cites W2038399651 @default.
• W2999648799 cites W2048647535 @default.
• W2999648799 cites W2054104356 @default.
• W2999648799 cites W2068195414 @default.
• W2999648799 cites W2071507281 @default.
• W2999648799 cites W2074721185 @default.
• W2999648799 cites W2075889321 @default.
• W2999648799 cites W2089944772 @default.
• W2999648799 cites W2105734762 @default.
• W2999648799 cites W2112340015 @default.
• W2999648799 cites W2113933847 @default.
• W2999648799 cites W2120331983 @default.
• W2999648799 cites W2121090593 @default.
• W2999648799 cites W2127588983 @default.
• W2999648799 cites W2130794824 @default.
• W2999648799 cites W2143149122 @default.
• W2999648799 cites W2147832388 @default.
• W2999648799 cites W2156390096 @default.
• W2999648799 cites W2157010562 @default.
• W2999648799 cites W2160666118 @default.
• W2999648799 cites W2182578492 @default.
• W2999648799 cites W2202486845 @default.
• W2999648799 cites W2326463211 @default.
• W2999648799 cites W2462990977 @default.
• W2999648799 cites W2524881570 @default.
• W2999648799 cites W2773293509 @default.
• W2999648799 cites W2792641862 @default.
• W2999648799 cites W2804455798 @default.
• W2999648799 cites W2805067622 @default.
• W2999648799 cites W2949581414 @default.
• W2999648799 cites W2951537203 @default.
• W2999648799 cites W301897234 @default.
• W2999648799 cites W4211241312 @default.
• W2999648799 cites W809574031 @default.
• W2999648799 doi "https://doi.org/10.1016/j.reth.2019.11.004" @default.
• W2999648799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6961757" @default.
• W2999648799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31970266" @default.
• W2999648799 hasPublicationYear "2020" @default.
• W2999648799 type Work @default.
• W2999648799 sameAs 2999648799 @default.
• W2999648799 citedByCount "34" @default.
• W2999648799 countsByYear W29996487992020 @default.
• W2999648799 countsByYear W29996487992021 @default.
• W2999648799 countsByYear W29996487992022 @default.
• W2999648799 countsByYear W29996487992023 @default.
• W2999648799 crossrefType "journal-article" @default.
• W2999648799 hasAuthorship W2999648799A5009454728 @default.
• W2999648799 hasAuthorship W2999648799A5016653415 @default.
• W2999648799 hasAuthorship W2999648799A5033997049 @default.
• W2999648799 hasAuthorship W2999648799A5045376146 @default.
• W2999648799 hasAuthorship W2999648799A5051458435 @default.
• W2999648799 hasAuthorship W2999648799A5051595442 @default.
• W2999648799 hasAuthorship W2999648799A5052288893 @default.
• W2999648799 hasAuthorship W2999648799A5053241809 @default.
• W2999648799 hasAuthorship W2999648799A5064241594 @default.
• W2999648799 hasAuthorship W2999648799A5068715003 @default.
• W2999648799 hasAuthorship W2999648799A5076002314 @default.
• W2999648799 hasAuthorship W2999648799A5076538361 @default.
• W2999648799 hasBestOaLocation W29996487991 @default.
• W2999648799 hasConcept C10854531 @default.
• W2999648799 hasConcept C126322002 @default.
• W2999648799 hasConcept C142724271 @default.
• W2999648799 hasConcept C150903083 @default.
• W2999648799 hasConcept C171056886 @default.

• next