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- W2999666736 abstract "Abstract Background and objective Diabetes imposes a worldwide burden on morbidity and mortality arising due to its heterogeneity in causative agents. Several major genetic mutations from childhood until adult predispose its progression. These such as “maturity-onset diabetes of the young” (MODY [MIM: 606391 ]) and neonatal diabetes (ND [MIM: 606176 ]), APPL1 [MIM: 604299 ], GCK-MODY, Glu29Asp, GFPT2 and insulin folding proteins. Identification of genetic mutations provides predicting tools as well as novel therapeutic approaches tailored to particular targets. Methods in this cross-sectional case-control study, 300 type 2 diabetic patients and 300 healthy individuals were adopted randomly. The polymorphisms of GFPT2 and Glu298Asp were investigated by PCR-RFLP method. Results A significant difference was observed regarding the Glu298Asp (p = 0.0112) and GFPT2 (p = 0.0011) genes variations and type 2 diabetes progression. Conclusion A variety of genetic mutations participate in the progression of diabetes. Thereby, their identification provides improved therapy, better prediction of disease prognosis and progression, genetic counseling, and probably prevention." @default.
- W2999666736 created "2020-01-23" @default.
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- W2999666736 date "2020-06-01" @default.
- W2999666736 modified "2023-10-14" @default.
- W2999666736 title "The association of GFPT2 and Glu 298 Asp gene variations to the type 2 diabetes" @default.
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- W2999666736 doi "https://doi.org/10.1016/j.genrep.2019.100579" @default.
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