FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999672092> ?p ?o ?g. }

• W2999672092 endingPage "720" @default.
• W2999672092 startingPage "712" @default.
• W2999672092 abstract "As an extremely addictive psychostimulant drug and an illicit dopaminergic neurotoxin, methamphetamine (METH) conducts to enhance satisfaction, feelings of alertness through influencing monoamine neurotransmitter systems. Long-lasting exposure to METH causes psychosis and increases the risk of neurodegeneration. 6-Formyl-5-isopropyl-3-hydroxymethyl-7-methyl-1H-indene (FIHMI) is a novel compound with potent antioxidant properties. This study was to investigate whether FIHMI could mitigate METH-induced photoreceptor cell toxicity. METH-caused cell toxicity was established in 661W cells and protective effects of FIHMI at different concentrations (1–10 µM) was examined. FIHMI significantly attenuated the METH-caused cell damage in 661W cells, evidenced by increasing cell viability and mitochondrial membrane potential, decreasing cytochrome c release and DNA fragmentation, inhibiting activities of caspase 3/9, and changing expression of apoptosis-related protein. Furthermore, FIHMI treatment decreased mRNA expression of Beclin-1 and LC3B protein expression in METH-induced 661W cells suggesting autophagy is reduced. FIHMI decreased the oxidative stress through increasing protein expression of nuclear factor (erythroid-derived 2)-like 2. These data demonstrated FIHMI could inhibit oxidative stress, which may also play an essential role in the regulation of METH-triggered apoptotic response, providing the scientific rational to develop FIHMI as the therapeutic agent to alleviate METH-induced photoreceptor cell toxicity." @default.
• W2999672092 created "2020-01-23" @default.
• W2999672092 creator A5013806789 @default.
• W2999672092 creator A5021129578 @default.
• W2999672092 creator A5075428902 @default.
• W2999672092 creator A5089893703 @default.
• W2999672092 date "2020-01-13" @default.
• W2999672092 modified "2023-09-23" @default.
• W2999672092 title "6-Formyl-5-isopropyl-3-hydroxymethyl- 7-methyl-1H-indene mitigates methamphetamine-induced photoreceptor cell toxicity through inhibiting oxidative stress" @default.
• W2999672092 cites W1491080263 @default.
• W2999672092 cites W1965347832 @default.
• W2999672092 cites W1968134244 @default.
• W2999672092 cites W1970781885 @default.
• W2999672092 cites W1973393483 @default.
• W2999672092 cites W1974236020 @default.
• W2999672092 cites W1987742034 @default.
• W2999672092 cites W1988437101 @default.
• W2999672092 cites W1990706801 @default.
• W2999672092 cites W1991336366 @default.
• W2999672092 cites W1997238548 @default.
• W2999672092 cites W1998108152 @default.
• W2999672092 cites W2016992422 @default.
• W2999672092 cites W2017299023 @default.
• W2999672092 cites W2031158487 @default.
• W2999672092 cites W2037667855 @default.
• W2999672092 cites W2067149213 @default.
• W2999672092 cites W2086202174 @default.
• W2999672092 cites W2120595804 @default.
• W2999672092 cites W2121610524 @default.
• W2999672092 cites W2343855628 @default.
• W2999672092 cites W2514084603 @default.
• W2999672092 cites W2591911682 @default.
• W2999672092 cites W2697145836 @default.
• W2999672092 cites W2758782039 @default.
• W2999672092 cites W2899310573 @default.
• W2999672092 cites W2904122887 @default.
• W2999672092 cites W4237575636 @default.
• W2999672092 doi "https://doi.org/10.1177/0960327119896617" @default.
• W2999672092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31928234" @default.
• W2999672092 hasPublicationYear "2020" @default.
• W2999672092 type Work @default.
• W2999672092 sameAs 2999672092 @default.
• W2999672092 citedByCount "3" @default.
• W2999672092 countsByYear W29996720922021 @default.
• W2999672092 countsByYear W29996720922022 @default.
• W2999672092 countsByYear W29996720922023 @default.
• W2999672092 crossrefType "journal-article" @default.
• W2999672092 hasAuthorship W2999672092A5013806789 @default.
• W2999672092 hasAuthorship W2999672092A5021129578 @default.
• W2999672092 hasAuthorship W2999672092A5075428902 @default.
• W2999672092 hasAuthorship W2999672092A5089893703 @default.
• W2999672092 hasConcept C166940927 @default.
• W2999672092 hasConcept C178790620 @default.
• W2999672092 hasConcept C185592680 @default.
• W2999672092 hasConcept C190283241 @default.
• W2999672092 hasConcept C2776151105 @default.
• W2999672092 hasConcept C2779989194 @default.
• W2999672092 hasConcept C2780114369 @default.
• W2999672092 hasConcept C2780369685 @default.
• W2999672092 hasConcept C2780376393 @default.
• W2999672092 hasConcept C29730261 @default.
• W2999672092 hasConcept C521977710 @default.
• W2999672092 hasConcept C53227056 @default.
• W2999672092 hasConcept C55493867 @default.
• W2999672092 hasConcept C86803240 @default.
• W2999672092 hasConcept C98274493 @default.
• W2999672092 hasConceptScore W2999672092C166940927 @default.
• W2999672092 hasConceptScore W2999672092C178790620 @default.
• W2999672092 hasConceptScore W2999672092C185592680 @default.
• W2999672092 hasConceptScore W2999672092C190283241 @default.
• W2999672092 hasConceptScore W2999672092C2776151105 @default.
• W2999672092 hasConceptScore W2999672092C2779989194 @default.
• W2999672092 hasConceptScore W2999672092C2780114369 @default.
• W2999672092 hasConceptScore W2999672092C2780369685 @default.
• W2999672092 hasConceptScore W2999672092C2780376393 @default.
• W2999672092 hasConceptScore W2999672092C29730261 @default.
• W2999672092 hasConceptScore W2999672092C521977710 @default.
• W2999672092 hasConceptScore W2999672092C53227056 @default.
• W2999672092 hasConceptScore W2999672092C55493867 @default.
• W2999672092 hasConceptScore W2999672092C86803240 @default.
• W2999672092 hasConceptScore W2999672092C98274493 @default.
• W2999672092 hasIssue "5" @default.
• W2999672092 hasLocation W29996720921 @default.
• W2999672092 hasLocation W29996720922 @default.
• W2999672092 hasOpenAccess W2999672092 @default.
• W2999672092 hasPrimaryLocation W29996720921 @default.
• W2999672092 hasRelatedWork W1979385642 @default.
• W2999672092 hasRelatedWork W2003491520 @default.
• W2999672092 hasRelatedWork W2026141666 @default.
• W2999672092 hasRelatedWork W2030714536 @default.
• W2999672092 hasRelatedWork W2081128169 @default.
• W2999672092 hasRelatedWork W225903741 @default.
• W2999672092 hasRelatedWork W2287053543 @default.
• W2999672092 hasRelatedWork W2411409896 @default.
• W2999672092 hasRelatedWork W2594122342 @default.
• W2999672092 hasRelatedWork W4223923931 @default.
• W2999672092 hasVolume "39" @default.
• W2999672092 isParatext "false" @default.

• next