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- W2999680179 abstract "Aim: Glucose intolerance associates with M1/M2 macrophage unbalance. We thus wanted to examine the effect of M2 macrophage administration on mouse model of glucose intolerance. Materials & methods: C57BL/6 mice fed a high-fat diet (HFD) for 12 weeks and then received thrice 20 mg/kg streptozotocin (HFD-GI). Bone marrow-derived stem cells were collected from donor mice and differentiated/activated into M2 macrophages for intraperitoneal administration into HFD-GI mice. Results: M2 macrophage treatment abolished glucose intolerance independently of obesity. M2 macrophage administration increased IL-10 in visceral adipose tissue and serum, but showed no effect on serum insulin. While nitric oxide synthase-2 and arginase-1 remained unaltered, M2 macrophage treatment restored AKT phosphorylation in visceral adipose tissue. Conclusion: M2 macrophage treatment abolishes glucose intolerance by increasing IL-10 and phosphorylated AKT." @default.
- W2999680179 created "2020-01-23" @default.
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- W2999680179 date "2020-01-01" @default.
- W2999680179 modified "2023-10-18" @default.
- W2999680179 title "M2 macrophage immunotherapy abolishes glucose intolerance by increasing IL-10 expression and AKT activation" @default.
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- W2999680179 doi "https://doi.org/10.2217/imt-2019-0080" @default.
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