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- W2999682815 abstract "Addressing the complexity of organogenesis at a system-wide level requires a complete understanding of adult cell types, their origin, and precursor relationships. The Drosophila ovary has been a model to study how coordinated stem cell units, germline, and somatic follicle stem cells maintain and renew an organ. However, lack of cell type-specific tools have limited our ability to study the origin of individual cell types and stem cell units. Here, we used a single-cell RNA sequencing approach to uncover all known cell types of the developing ovary, reveal transcriptional signatures, and identify cell type-specific markers for lineage tracing. Our study identifies a novel cell type corresponding to the elusive follicle stem cell precursors and predicts subtypes of known cell types. Altogether, we reveal a previously unanticipated complexity of the developing ovary and provide a comprehensive resource for the systematic analysis of ovary morphogenesis." @default.
- W2999682815 created "2020-01-23" @default.
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- W2999682815 date "2020-01-09" @default.
- W2999682815 modified "2023-10-18" @default.
- W2999682815 title "A single-cell atlas of the developing <i>Drosophila</i> ovary identifies follicle stem cell progenitors" @default.
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- W2999682815 doi "https://doi.org/10.1101/gad.330464.119" @default.
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