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- W2999686439 abstract "As a ubiquitous nuclear protein, high-mobility group box 1 (HMGB1) is constitutively expressed and can be actively secreted by macrophages/monocytes, as well as passively released from damaged cells following pathological injuries. Studies indicate that HMGB1 functions as a mediator of infection- and injury-elicited inflammatory diseases. Although intracellular HMGB1 functions as a regulator of tumorigenesis, epigenetic anticancer agents or therapeutic γ-ray irradiation could also cause active secretion or passive release of HMGB1, enabling serum HMGB1 to serve as a biomarker for the diagnosis and therapy of various cancers. Here we describe a semiquantitative immune blotting method to measure HMGB1 in human serum, in comparison with a commercially available HMGB1 enzyme-linked immunosorbent assay (ELISA) technique." @default.
- W2999686439 created "2020-01-23" @default.
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- W2999686439 date "2020-01-01" @default.
- W2999686439 modified "2023-09-27" @default.
- W2999686439 title "Analysis of Circulating HMGB1 in Human Serum" @default.
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- W2999686439 doi "https://doi.org/10.1007/978-1-0716-0247-8_2" @default.
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