Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999689892> ?p ?o ?g. }
- W2999689892 abstract "Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a mutant defective in mRNA methylation (m6A). Here we show that m6A can be mapped in full-length mRNAs transcriptome-wide and reveal the combinatorial diversity of cap-associated transcription start sites, splicing events, poly(A) site choice and poly(A) tail length. Loss of m6A from 3’ untranslated regions is associated with decreased relative transcript abundance and defective RNA 3′ end formation. A functional consequence of disrupted m6A is a lengthening of the circadian period. We conclude that nanopore direct RNA sequencing can reveal the complexity of mRNA processing and modification in full-length single molecule reads. These findings can refine Arabidopsis genome annotation. Further, applying this approach to less well-studied species could transform our understanding of what their genomes encode." @default.
- W2999689892 created "2020-01-23" @default.
- W2999689892 creator A5023223230 @default.
- W2999689892 creator A5024900384 @default.
- W2999689892 creator A5040931756 @default.
- W2999689892 creator A5048534433 @default.
- W2999689892 creator A5048867422 @default.
- W2999689892 creator A5064502114 @default.
- W2999689892 creator A5067128274 @default.
- W2999689892 creator A5067517396 @default.
- W2999689892 creator A5082043302 @default.
- W2999689892 date "2020-01-14" @default.
- W2999689892 modified "2023-10-18" @default.
- W2999689892 title "Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification" @default.
- W2999689892 cites W106829319 @default.
- W2999689892 cites W107998980 @default.
- W2999689892 cites W1494075612 @default.
- W2999689892 cites W1519765314 @default.
- W2999689892 cites W1779683016 @default.
- W2999689892 cites W1979764753 @default.
- W2999689892 cites W1991807334 @default.
- W2999689892 cites W2009458183 @default.
- W2999689892 cites W2010088308 @default.
- W2999689892 cites W2011131953 @default.
- W2999689892 cites W2013532868 @default.
- W2999689892 cites W2021341670 @default.
- W2999689892 cites W2025604175 @default.
- W2999689892 cites W2036065307 @default.
- W2999689892 cites W2036897871 @default.
- W2999689892 cites W2039725641 @default.
- W2999689892 cites W2055185462 @default.
- W2999689892 cites W2058832897 @default.
- W2999689892 cites W2065226618 @default.
- W2999689892 cites W2081468353 @default.
- W2999689892 cites W2097664345 @default.
- W2999689892 cites W2101222632 @default.
- W2999689892 cites W2102619694 @default.
- W2999689892 cites W2104706770 @default.
- W2999689892 cites W2108130533 @default.
- W2999689892 cites W2108234281 @default.
- W2999689892 cites W2110905563 @default.
- W2999689892 cites W2112242563 @default.
- W2999689892 cites W2114104545 @default.
- W2999689892 cites W2114850508 @default.
- W2999689892 cites W2117688129 @default.
- W2999689892 cites W2119204091 @default.
- W2999689892 cites W2124398588 @default.
- W2999689892 cites W2139306346 @default.
- W2999689892 cites W2140952049 @default.
- W2999689892 cites W2142678478 @default.
- W2999689892 cites W2144905501 @default.
- W2999689892 cites W2156723264 @default.
- W2999689892 cites W2157009395 @default.
- W2999689892 cites W2157107905 @default.
- W2999689892 cites W2160545136 @default.
- W2999689892 cites W2166494447 @default.
- W2999689892 cites W2167866392 @default.
- W2999689892 cites W2169456326 @default.
- W2999689892 cites W2169669582 @default.
- W2999689892 cites W2170669858 @default.
- W2999689892 cites W2180404227 @default.
- W2999689892 cites W2341861303 @default.
- W2999689892 cites W2342299314 @default.
- W2999689892 cites W2432815617 @default.
- W2999689892 cites W2466739815 @default.
- W2999689892 cites W2516790602 @default.
- W2999689892 cites W2519009432 @default.
- W2999689892 cites W2523875478 @default.
- W2999689892 cites W2529838505 @default.
- W2999689892 cites W2590034108 @default.
- W2999689892 cites W2592811885 @default.
- W2999689892 cites W2599186967 @default.
- W2999689892 cites W2605929552 @default.
- W2999689892 cites W2608560932 @default.
- W2999689892 cites W2613267149 @default.
- W2999689892 cites W2616848081 @default.
- W2999689892 cites W2627064270 @default.
- W2999689892 cites W2735868438 @default.
- W2999689892 cites W2765231623 @default.
- W2999689892 cites W2767281352 @default.
- W2999689892 cites W2767360874 @default.
- W2999689892 cites W2785666191 @default.
- W2999689892 cites W2789843538 @default.
- W2999689892 cites W2793785833 @default.
- W2999689892 cites W2802282671 @default.
- W2999689892 cites W2803324327 @default.
- W2999689892 cites W2881827384 @default.
- W2999689892 cites W2889062795 @default.
- W2999689892 cites W2890344905 @default.
- W2999689892 cites W2892346327 @default.
- W2999689892 cites W2898202447 @default.
- W2999689892 cites W2899065760 @default.
- W2999689892 cites W2901438556 @default.
- W2999689892 cites W2905515949 @default.
- W2999689892 cites W2936958295 @default.
- W2999689892 cites W2947725313 @default.
- W2999689892 cites W2948918160 @default.
- W2999689892 cites W2950063384 @default.
- W2999689892 cites W2950465644 @default.
- W2999689892 cites W2952109315 @default.