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- W2999692093 endingPage "416" @default.
- W2999692093 startingPage "361" @default.
- W2999692093 abstract "Abstract Four cell acidifiers, of which three are metabolic modifiers and one is an immunomodulator, are discussed in this chapter: 2-deoxy- d -glucose, metformin and dichloroacetate as metabolic acidifiers and cimetidine as immunomodulator and acidifier. The first one acts mainly through a glycolytic stop depleting cellular energy that decreases the activity of NHE1. Metformin is a mitochondrial Complex I inhibitor that while decreasing OXPHOS and as a consequence, increases glycolysis and lactate production. Dichloroacetate restores oxidative phosphorylation by inhibiting phosphodehydrogenase kinase (PDK). The different mechanisms of action of these compounds allow certain synergistic combination among them. The only metabolic modifier in clinical use (FDA approved) is metformin. Cimetidine however, although FDA approved is not available in most countries." @default.
- W2999692093 created "2020-01-23" @default.
- W2999692093 creator A5020257113 @default.
- W2999692093 creator A5024538800 @default.
- W2999692093 creator A5043062758 @default.
- W2999692093 date "2020-01-01" @default.
- W2999692093 modified "2023-09-26" @default.
- W2999692093 title "Pharmacological interventions part IV: Metabolic modifiers" @default.
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