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• W2999694329 abstract "This study aims to design photo-triggered micelles by using a natural base polymer. Chitosan was functionalized with thiourea, and in the next step, it was modified by grafting poly(l-lactide), poly(N-isopropylacrylamide), and poly(acrylamide) in determined ratio to form thermo-sensitive micelles. The sulfur content of chitosan@thiourea was measured about 2%. Grafting of polymers on chitosan was characterized by FT-IR and NMR techniques. The critical micellar concentration was measured by using photo luminescence spectroscopy. The size and surface morphology experiments revealed that average size of micelles is about 14 nm, and the length and width of GNRs are about 65 and 19 nm, respectively. The percent of conjugated GNRs to the micelles was about 11%. The conjugation of gold nanorods onto micelles, through gold-thiolate complex formation, induces photo sensitivity to the nano-vehicle. The exposure of NIR light creates local heat by GNRs, shrinkage of thermal-sensitive moiety of micelles, and drug release, simultaneously. Drug release studies demonstrated that at a determined time, paclitaxel was released 38% after exposure to NIR light compared to 15 and 35% in 37 and 45 °C, respectively. The cytotoxicity tests of Paclitaxel loaded micelles were carried out by MTT assay against MCF7 cells." @default.
• W2999694329 created "2020-01-23" @default.
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• W2999694329 date "2020-04-01" @default.
• W2999694329 modified "2023-10-14" @default.
• W2999694329 title "Synthesis of micelles based on chitosan functionalized with gold nanorods as a light sensitive drug delivery vehicle" @default.
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• W2999694329 doi "https://doi.org/10.1016/j.ijbiomac.2020.01.162" @default.
• W2999694329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31958558" @default.
• W2999694329 hasPublicationYear "2020" @default.
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