FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999694364> ?p ?o ?g. }

• W2999694364 abstract "Background: Browning of white adipose tissues (WAT) is recognized as a novel way to combat obesity and its related comorbidities. Thus, a lot of dietary agents contributing to browning of WAT have been identified. Objective: In this study, we try to explore the mechanism of the browning of WAT induced by resveratrol (Res) in 3T3-L1 adipocytes. Methods: The levels of cell viability and lipid accumulation were evaluated under different concentrations of Res. Cell signaling pathway analysis was performed to investigate the possible mechanisms of the WAT browning effect of Res in 3T3-L1 cells. Results: We found that Res induced the brown fat-like phenotype by activating protein expressions of brown adipocyte-specific markers, such as peroxisome proliferator-activated receptor gamma (PPAR-γ), peroxisome proliferator- activated receptor gamma coactivator-1 alpha (PGC-1α), and uncoupling protein 1 (UCP1). Besides, Res reduced lipid accumulation, as shown by Oil Red O staining. The increased small lipid droplets implied that Res-treated 3T3-L1 adipocytes had some features of brown adipocytes. The brown fat-like phenotype in 3T3-L1 adipocytes induced by Res was possibly mediated by activation of mammalian target of rapamycin (mTOR), as brown adipocyte-specific markers were decreased by rapamycin, an inhibitor of mTOR and the MHY1485 treatment, an activator of mTOR, showed the similar effect of Res on browning markers. Conclusions: Res induced brown-like adipocyte phenotype in 3T3-L1 adipocytes partly via mTOR pathway, which provided new insights into the utilization of Res to prevent obesity and related comorbidities." @default.
• W2999694364 created "2020-01-23" @default.
• W2999694364 creator A5007492792 @default.
• W2999694364 creator A5020631342 @default.
• W2999694364 creator A5032871667 @default.
• W2999694364 creator A5034623547 @default.
• W2999694364 creator A5041594291 @default.
• W2999694364 creator A5068156479 @default.
• W2999694364 creator A5073744778 @default.
• W2999694364 creator A5091306446 @default.
• W2999694364 date "2020-01-14" @default.
• W2999694364 modified "2023-09-25" @default.
• W2999694364 title "Resveratrol-induced brown fat-like phenotype in 3T3-L1 adipocytes partly via mTOR pathway" @default.
• W2999694364 cites W177963654 @default.
• W2999694364 cites W1946314517 @default.
• W2999694364 cites W1971585815 @default.
• W2999694364 cites W1975120418 @default.
• W2999694364 cites W2027753197 @default.
• W2999694364 cites W2029044425 @default.
• W2999694364 cites W2033732701 @default.
• W2999694364 cites W2045697440 @default.
• W2999694364 cites W2061096962 @default.
• W2999694364 cites W2065667074 @default.
• W2999694364 cites W2074631079 @default.
• W2999694364 cites W2085951097 @default.
• W2999694364 cites W2089435895 @default.
• W2999694364 cites W2114918609 @default.
• W2999694364 cites W2124802842 @default.
• W2999694364 cites W2151470490 @default.
• W2999694364 cites W2175684833 @default.
• W2999694364 cites W2295309463 @default.
• W2999694364 cites W2310813458 @default.
• W2999694364 cites W2328791756 @default.
• W2999694364 cites W2383894930 @default.
• W2999694364 cites W2422017503 @default.
• W2999694364 cites W2529255361 @default.
• W2999694364 cites W2556619457 @default.
• W2999694364 cites W2562244434 @default.
• W2999694364 cites W2589236941 @default.
• W2999694364 cites W2591209570 @default.
• W2999694364 cites W2598007924 @default.
• W2999694364 cites W2735376054 @default.
• W2999694364 cites W2875128883 @default.
• W2999694364 cites W2916897214 @default.
• W2999694364 cites W2944710657 @default.
• W2999694364 cites W2956725178 @default.
• W2999694364 cites W2040548834 @default.
• W2999694364 doi "https://doi.org/10.29219/fnr.v64.3656" @default.
• W2999694364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6983979" @default.
• W2999694364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32047421" @default.
• W2999694364 hasPublicationYear "2020" @default.
• W2999694364 type Work @default.
• W2999694364 sameAs 2999694364 @default.
• W2999694364 citedByCount "17" @default.
• W2999694364 countsByYear W29996943642020 @default.
• W2999694364 countsByYear W29996943642021 @default.
• W2999694364 countsByYear W29996943642022 @default.
• W2999694364 countsByYear W29996943642023 @default.
• W2999694364 crossrefType "journal-article" @default.
• W2999694364 hasAuthorship W2999694364A5007492792 @default.
• W2999694364 hasAuthorship W2999694364A5020631342 @default.
• W2999694364 hasAuthorship W2999694364A5032871667 @default.
• W2999694364 hasAuthorship W2999694364A5034623547 @default.
• W2999694364 hasAuthorship W2999694364A5041594291 @default.
• W2999694364 hasAuthorship W2999694364A5068156479 @default.
• W2999694364 hasAuthorship W2999694364A5073744778 @default.
• W2999694364 hasAuthorship W2999694364A5091306446 @default.
• W2999694364 hasBestOaLocation W29996943641 @default.
• W2999694364 hasConcept C126322002 @default.
• W2999694364 hasConcept C134018914 @default.
• W2999694364 hasConcept C142536801 @default.
• W2999694364 hasConcept C143128242 @default.
• W2999694364 hasConcept C151955695 @default.
• W2999694364 hasConcept C171089720 @default.
• W2999694364 hasConcept C185592680 @default.
• W2999694364 hasConcept C25095133 @default.
• W2999694364 hasConcept C2776175234 @default.
• W2999694364 hasConcept C2776816829 @default.
• W2999694364 hasConcept C2780642333 @default.
• W2999694364 hasConcept C53007507 @default.
• W2999694364 hasConcept C55493867 @default.
• W2999694364 hasConcept C62478195 @default.
• W2999694364 hasConcept C71924100 @default.
• W2999694364 hasConcept C81979416 @default.
• W2999694364 hasConcept C86554907 @default.
• W2999694364 hasConcept C86803240 @default.
• W2999694364 hasConcept C95444343 @default.
• W2999694364 hasConceptScore W2999694364C126322002 @default.
• W2999694364 hasConceptScore W2999694364C134018914 @default.
• W2999694364 hasConceptScore W2999694364C142536801 @default.
• W2999694364 hasConceptScore W2999694364C143128242 @default.
• W2999694364 hasConceptScore W2999694364C151955695 @default.
• W2999694364 hasConceptScore W2999694364C171089720 @default.
• W2999694364 hasConceptScore W2999694364C185592680 @default.
• W2999694364 hasConceptScore W2999694364C25095133 @default.
• W2999694364 hasConceptScore W2999694364C2776175234 @default.
• W2999694364 hasConceptScore W2999694364C2776816829 @default.
• W2999694364 hasConceptScore W2999694364C2780642333 @default.
• W2999694364 hasConceptScore W2999694364C53007507 @default.
• W2999694364 hasConceptScore W2999694364C55493867 @default.

• next