FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999695880> ?p ?o ?g. }

• W2999695880 endingPage "117" @default.
• W2999695880 startingPage "108" @default.
• W2999695880 abstract "The choroid plexus (ChP) is a major source of cerebrospinal fluid (CSF) production, with a direct and indirect role in protein clearance, and pathogenesis of Alzheimer's disease (AD). Here, we tested the link between the ChP volume and levels of CSF proteins in 2 data sets of (i) healthy controls, mild cognitive impairment (MCI), and AD patients from the Alzheimer's Disease Neuroimaging Initiative (ADNI) (N = 509), and (ii) healthy controls and Parkinson's disease (PD) patients from the Parkinson's Progression Markers Initiative (N = 302). All patients had baseline CSF proteins (amyloid-β, total and phosphorylated-tau and α-synuclein (only in Parkinson's Progression Markers Initiative)). ChP was automatically segmented on 3T structural T1-weighted MRIs. We found negative associations between ChP volume and CSF proteins, which were stronger in healthy controls, early-MCI patients, and PD patients compared with late-MCI and AD patients. Further grouping of patients of ADNI dataset into amyloid-positive and amyloid-negative based on their florbetapir (AV45) PET imaging showed that the association between ChP volume and CSF proteins (t/p-tau) was lower in amyloid-positive group. Our findings support the possible role of ChP in the clearance of CSF proteins, provide evidence for ChP dysfunction in AD, and suggest the need to account for the ChP volume in future studies of CSF-based biomarkers." @default.
• W2999695880 created "2020-01-23" @default.
• W2999695880 creator A5007618142 @default.
• W2999695880 creator A5056623917 @default.
• W2999695880 creator A5084280420 @default.
• W2999695880 creator A5087368167 @default.
• W2999695880 date "2020-05-01" @default.
• W2999695880 modified "2023-10-16" @default.
• W2999695880 title "Choroid plexus volume is associated with levels of CSF proteins: relevance for Alzheimer's and Parkinson's disease" @default.
• W2999695880 cites W1543494855 @default.
• W2999695880 cites W1547689749 @default.
• W2999695880 cites W1616122655 @default.
• W2999695880 cites W1757198209 @default.
• W2999695880 cites W1767010801 @default.
• W2999695880 cites W1831805455 @default.
• W2999695880 cites W1972025839 @default.
• W2999695880 cites W1991746958 @default.
• W2999695880 cites W1992014046 @default.
• W2999695880 cites W2016787780 @default.
• W2999695880 cites W2033132890 @default.
• W2999695880 cites W2034547295 @default.
• W2999695880 cites W2059152389 @default.
• W2999695880 cites W2070448139 @default.
• W2999695880 cites W2077583059 @default.
• W2999695880 cites W2095851810 @default.
• W2999695880 cites W2112065144 @default.
• W2999695880 cites W211905087 @default.
• W2999695880 cites W2133649359 @default.
• W2999695880 cites W2146443559 @default.
• W2999695880 cites W2152216365 @default.
• W2999695880 cites W2164740566 @default.
• W2999695880 cites W2167183660 @default.
• W2999695880 cites W2206268550 @default.
• W2999695880 cites W2214356616 @default.
• W2999695880 cites W2299774019 @default.
• W2999695880 cites W2335939308 @default.
• W2999695880 cites W2561036812 @default.
• W2999695880 cites W2570749988 @default.
• W2999695880 cites W2613431089 @default.
• W2999695880 cites W2765181675 @default.
• W2999695880 cites W2791214532 @default.
• W2999695880 cites W2885225461 @default.
• W2999695880 doi "https://doi.org/10.1016/j.neurobiolaging.2020.01.005" @default.
• W2999695880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32107064" @default.
• W2999695880 hasPublicationYear "2020" @default.
• W2999695880 type Work @default.
• W2999695880 sameAs 2999695880 @default.
• W2999695880 citedByCount "40" @default.
• W2999695880 countsByYear W29996958802020 @default.
• W2999695880 countsByYear W29996958802021 @default.
• W2999695880 countsByYear W29996958802022 @default.
• W2999695880 countsByYear W29996958802023 @default.
• W2999695880 crossrefType "journal-article" @default.
• W2999695880 hasAuthorship W2999695880A5007618142 @default.
• W2999695880 hasAuthorship W2999695880A5056623917 @default.
• W2999695880 hasAuthorship W2999695880A5084280420 @default.
• W2999695880 hasAuthorship W2999695880A5087368167 @default.
• W2999695880 hasBestOaLocation W29996958801 @default.
• W2999695880 hasConcept C126322002 @default.
• W2999695880 hasConcept C142724271 @default.
• W2999695880 hasConcept C143998085 @default.
• W2999695880 hasConcept C15744967 @default.
• W2999695880 hasConcept C16568411 @default.
• W2999695880 hasConcept C169760540 @default.
• W2999695880 hasConcept C2776538271 @default.
• W2999695880 hasConcept C2777633098 @default.
• W2999695880 hasConcept C2778373026 @default.
• W2999695880 hasConcept C2779134260 @default.
• W2999695880 hasConcept C2779651940 @default.
• W2999695880 hasConcept C2779734285 @default.
• W2999695880 hasConcept C2780942790 @default.
• W2999695880 hasConcept C2781073650 @default.
• W2999695880 hasConcept C39920043 @default.
• W2999695880 hasConcept C502032728 @default.
• W2999695880 hasConcept C529278444 @default.
• W2999695880 hasConcept C58693492 @default.
• W2999695880 hasConcept C71924100 @default.
• W2999695880 hasConceptScore W2999695880C126322002 @default.
• W2999695880 hasConceptScore W2999695880C142724271 @default.
• W2999695880 hasConceptScore W2999695880C143998085 @default.
• W2999695880 hasConceptScore W2999695880C15744967 @default.
• W2999695880 hasConceptScore W2999695880C16568411 @default.
• W2999695880 hasConceptScore W2999695880C169760540 @default.
• W2999695880 hasConceptScore W2999695880C2776538271 @default.
• W2999695880 hasConceptScore W2999695880C2777633098 @default.
• W2999695880 hasConceptScore W2999695880C2778373026 @default.
• W2999695880 hasConceptScore W2999695880C2779134260 @default.
• W2999695880 hasConceptScore W2999695880C2779651940 @default.
• W2999695880 hasConceptScore W2999695880C2779734285 @default.
• W2999695880 hasConceptScore W2999695880C2780942790 @default.
• W2999695880 hasConceptScore W2999695880C2781073650 @default.
• W2999695880 hasConceptScore W2999695880C39920043 @default.
• W2999695880 hasConceptScore W2999695880C502032728 @default.
• W2999695880 hasConceptScore W2999695880C529278444 @default.
• W2999695880 hasConceptScore W2999695880C58693492 @default.
• W2999695880 hasConceptScore W2999695880C71924100 @default.
• W2999695880 hasFunder F4320309697 @default.
• W2999695880 hasLocation W29996958801 @default.

• next