FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999695935> ?p ?o ?g. }

• W2999695935 abstract "Abstract The centrosome is the main organizer of microtubules and as such, its position is a key determinant of polarized cell functions. As the name says, the default position of the centrosome is considered to be the cell geometrical center. However, the mechanism regulating centrosome positioning is still unclear and often confused with the mechanism regulating the position of the nucleus to which it is linked. Here we used enucleated cells plated on adhesive micropatterns to impose regular and precise geometrical conditions to centrosome-microtubule networks. Although frequently observed there, the equilibrium position of the centrosome is not systematically at the cell geometrical center and can be close to cell edge. Centrosome positioning appears to respond accurately to the architecture and anisotropy of the actin network, which constitutes, rather than cell shape, the actual spatial boundary conditions the microtubule network is sensitive to. We found that the contraction of the actin network defines a peripheral margin, in which microtubules appeared bent by compressive forces. The disassembly of the actin network away from the cell edges defines an inner zone where actin bundles were absent and microtubules were more radially organized. The production of dynein-based forces on microtubules places the centrosome at the center of this inner zone. Cell adhesion pattern and contractile forces define the shape and position of the inner zone in which the centrosome-microtubule network is centered." @default.
• W2999695935 created "2020-01-23" @default.
• W2999695935 creator A5004905921 @default.
• W2999695935 creator A5017317489 @default.
• W2999695935 creator A5019461224 @default.
• W2999695935 creator A5023275493 @default.
• W2999695935 creator A5041910238 @default.
• W2999695935 creator A5052665492 @default.
• W2999695935 creator A5061615379 @default.
• W2999695935 creator A5065590224 @default.
• W2999695935 creator A5074987069 @default.
• W2999695935 date "2020-01-07" @default.
• W2999695935 modified "2023-10-18" @default.
• W2999695935 title "Acto-myosin network geometry defines centrosome position" @default.
• W2999695935 cites W1503265874 @default.
• W2999695935 cites W1861708461 @default.
• W2999695935 cites W1970771850 @default.
• W2999695935 cites W1975022818 @default.
• W2999695935 cites W1977993235 @default.
• W2999695935 cites W1980541575 @default.
• W2999695935 cites W1982173442 @default.
• W2999695935 cites W1985725667 @default.
• W2999695935 cites W1992480844 @default.
• W2999695935 cites W1994186189 @default.
• W2999695935 cites W1995405192 @default.
• W2999695935 cites W2001947684 @default.
• W2999695935 cites W2003997462 @default.
• W2999695935 cites W2007744474 @default.
• W2999695935 cites W2011205671 @default.
• W2999695935 cites W2025136907 @default.
• W2999695935 cites W2030041577 @default.
• W2999695935 cites W2036736619 @default.
• W2999695935 cites W2038492953 @default.
• W2999695935 cites W2039678463 @default.
• W2999695935 cites W2044987021 @default.
• W2999695935 cites W2046963960 @default.
• W2999695935 cites W2048718074 @default.
• W2999695935 cites W2049469649 @default.
• W2999695935 cites W2057163374 @default.
• W2999695935 cites W2070393436 @default.
• W2999695935 cites W2073051491 @default.
• W2999695935 cites W2076510352 @default.
• W2999695935 cites W2084200985 @default.
• W2999695935 cites W2091829961 @default.
• W2999695935 cites W2098547893 @default.
• W2999695935 cites W2099010190 @default.
• W2999695935 cites W2111428426 @default.
• W2999695935 cites W2112071772 @default.
• W2999695935 cites W2117291656 @default.
• W2999695935 cites W2121792528 @default.
• W2999695935 cites W2126931729 @default.
• W2999695935 cites W2132907046 @default.
• W2999695935 cites W2141391862 @default.
• W2999695935 cites W2145488605 @default.
• W2999695935 cites W2152969835 @default.
• W2999695935 cites W2157201312 @default.
• W2999695935 cites W2157920463 @default.
• W2999695935 cites W2159870289 @default.
• W2999695935 cites W2162802670 @default.
• W2999695935 cites W2167463357 @default.
• W2999695935 cites W2168480092 @default.
• W2999695935 cites W2283355204 @default.
• W2999695935 cites W2297213050 @default.
• W2999695935 cites W2499236700 @default.
• W2999695935 cites W2522470354 @default.
• W2999695935 cites W2560870713 @default.
• W2999695935 cites W2753831979 @default.
• W2999695935 cites W2784402222 @default.
• W2999695935 cites W2784942939 @default.
• W2999695935 cites W2792933886 @default.
• W2999695935 cites W2803947488 @default.
• W2999695935 cites W2885248243 @default.
• W2999695935 cites W2886038505 @default.
• W2999695935 cites W2896737648 @default.
• W2999695935 cites W2900902086 @default.
• W2999695935 cites W2913551921 @default.
• W2999695935 cites W2943884404 @default.
• W2999695935 cites W2953276182 @default.
• W2999695935 doi "https://doi.org/10.1101/2020.01.07.896969" @default.
• W2999695935 hasPublicationYear "2020" @default.
• W2999695935 type Work @default.
• W2999695935 sameAs 2999695935 @default.
• W2999695935 citedByCount "3" @default.
• W2999695935 countsByYear W29996959352020 @default.
• W2999695935 countsByYear W29996959352021 @default.
• W2999695935 countsByYear W29996959352022 @default.
• W2999695935 crossrefType "posted-content" @default.
• W2999695935 hasAuthorship W2999695935A5004905921 @default.
• W2999695935 hasAuthorship W2999695935A5017317489 @default.
• W2999695935 hasAuthorship W2999695935A5019461224 @default.
• W2999695935 hasAuthorship W2999695935A5023275493 @default.
• W2999695935 hasAuthorship W2999695935A5041910238 @default.
• W2999695935 hasAuthorship W2999695935A5052665492 @default.
• W2999695935 hasAuthorship W2999695935A5061615379 @default.
• W2999695935 hasAuthorship W2999695935A5065590224 @default.
• W2999695935 hasAuthorship W2999695935A5074987069 @default.
• W2999695935 hasBestOaLocation W29996959351 @default.
• W2999695935 hasConcept C10447061 @default.
• W2999695935 hasConcept C104672736 @default.
• W2999695935 hasConcept C125705527 @default.

• next