Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999696321> ?p ?o ?g. }
- W2999696321 abstract "Abstract Background The current objective is to evaluate the effect of frankincense oil on the convulsions and the associated neurochemical alterations produced in pilocarpine-induced status epilepticus rat model. Methods Rats were divided randomly into: control, status epilepticus rat model and rat model of status epilepticus pretreated with frankincense oil daily for 5 days before pilocarpine treatment. On the fifth day, after pilocarpine injection, rats were observed to evaluate the severity of seizures for 2 h. The oxidative stress parameters malondialdehyde, reduced glutathione and nitric oxide, the proinflammatory cytokines interleukin-6 and interleukin-1β and acetylcholinesterase were determined in the cortex, hippocampus and striatum. Dopamine, norepinephrine and serotonin were measured in the cortex and striatum. Results The status epilepticus model exhibited repetitive seizures in the form of generalized tonic- clonic convulsions after 30 min. of pilocarpine injection. This was associated with a significant increase in the levels of malondialdehyde and nitric oxide and a significant decrease in reduced glutathione in the three regions. A significant increase was also observed in interleukin-1β, interleukin-6 and acetylcholinesterase. In the cortex and striatum, a significant decrease was recorded in monoamine levels. Pretreatment of rat model of status epilepticus with frankincense oil decreased the severity of seizures that appeared in the form of tremors and facial automatisms and prevented the increase in malondialdehyde, nitric oxide, interleukin-1β, interleukin-6 and acetylcholinesterase and the decrease in reduced glutathione induced by pilocarpine in the studied brain regions. Frankincense oil failed to restore the decreased level of cortical serotonin and dopamine. In the striatum, frankincense oil improved the levels of serotonin and norepinephrine but failed to restore the decreased dopamine levels. Conclusion It is clear from the present results that frankincense oil reduced the severity of seizures induced by pilocarpine. This could be mediated by its potent antioxidant and anti-inflammatory effects." @default.
- W2999696321 created "2020-01-23" @default.
- W2999696321 creator A5027814734 @default.
- W2999696321 creator A5038637267 @default.
- W2999696321 creator A5058746961 @default.
- W2999696321 creator A5079697438 @default.
- W2999696321 creator A5084255812 @default.
- W2999696321 date "2020-01-03" @default.
- W2999696321 modified "2023-10-17" @default.
- W2999696321 title "Effect of frankincense oil on the neurochemical changes induced in rat model of status epilepticus" @default.
- W2999696321 cites W1487894289 @default.
- W2999696321 cites W1500346664 @default.
- W2999696321 cites W1538399032 @default.
- W2999696321 cites W1552265434 @default.
- W2999696321 cites W1577936879 @default.
- W2999696321 cites W1756596146 @default.
- W2999696321 cites W1844162254 @default.
- W2999696321 cites W1963865415 @default.
- W2999696321 cites W1970314590 @default.
- W2999696321 cites W1971048984 @default.
- W2999696321 cites W1971335269 @default.
- W2999696321 cites W1973832324 @default.
- W2999696321 cites W1974799637 @default.
- W2999696321 cites W1977681279 @default.
- W2999696321 cites W1983336703 @default.
- W2999696321 cites W1984799539 @default.
- W2999696321 cites W1994188497 @default.
- W2999696321 cites W1995331974 @default.
- W2999696321 cites W1995444099 @default.
- W2999696321 cites W1997059788 @default.
- W2999696321 cites W2001149828 @default.
- W2999696321 cites W2003599597 @default.
- W2999696321 cites W2004271569 @default.
- W2999696321 cites W2004368602 @default.
- W2999696321 cites W2015268116 @default.
- W2999696321 cites W2017061363 @default.
- W2999696321 cites W2017728901 @default.
- W2999696321 cites W2021163482 @default.
- W2999696321 cites W2022472848 @default.
- W2999696321 cites W2023205553 @default.
- W2999696321 cites W2023811880 @default.
- W2999696321 cites W2024943713 @default.
- W2999696321 cites W2025681573 @default.
- W2999696321 cites W2026732923 @default.
- W2999696321 cites W2028772150 @default.
- W2999696321 cites W2029549580 @default.
- W2999696321 cites W2030663705 @default.
- W2999696321 cites W2032578724 @default.
- W2999696321 cites W2032778529 @default.
- W2999696321 cites W2033859819 @default.
- W2999696321 cites W2033868134 @default.
- W2999696321 cites W2038205497 @default.
- W2999696321 cites W2042829577 @default.
- W2999696321 cites W2049192526 @default.
- W2999696321 cites W2057141589 @default.
- W2999696321 cites W2057363797 @default.
- W2999696321 cites W2058270773 @default.
- W2999696321 cites W2059110340 @default.
- W2999696321 cites W2061751395 @default.
- W2999696321 cites W2074687883 @default.
- W2999696321 cites W2074752153 @default.
- W2999696321 cites W2076856648 @default.
- W2999696321 cites W2077272625 @default.
- W2999696321 cites W2082858741 @default.
- W2999696321 cites W2083228186 @default.
- W2999696321 cites W2085450591 @default.
- W2999696321 cites W2089428281 @default.
- W2999696321 cites W2093238337 @default.
- W2999696321 cites W2096179357 @default.
- W2999696321 cites W2098569132 @default.
- W2999696321 cites W2105401833 @default.
- W2999696321 cites W2139911439 @default.
- W2999696321 cites W2141602788 @default.
- W2999696321 cites W2145903555 @default.
- W2999696321 cites W2146933403 @default.
- W2999696321 cites W2155416349 @default.
- W2999696321 cites W2163409843 @default.
- W2999696321 cites W2166844443 @default.
- W2999696321 cites W2167121498 @default.
- W2999696321 cites W2169478020 @default.
- W2999696321 cites W2207910629 @default.
- W2999696321 cites W2342832305 @default.
- W2999696321 cites W2510140868 @default.
- W2999696321 cites W2557139481 @default.
- W2999696321 cites W2571645241 @default.
- W2999696321 cites W2573888969 @default.
- W2999696321 cites W2591583808 @default.
- W2999696321 cites W2804744537 @default.
- W2999696321 cites W2923009100 @default.
- W2999696321 cites W4211013529 @default.
- W2999696321 cites W4230990232 @default.
- W2999696321 cites W4252106688 @default.
- W2999696321 doi "https://doi.org/10.1186/s40816-019-0139-6" @default.
- W2999696321 hasPublicationYear "2020" @default.
- W2999696321 type Work @default.
- W2999696321 sameAs 2999696321 @default.
- W2999696321 citedByCount "1" @default.
- W2999696321 countsByYear W29996963212023 @default.
- W2999696321 crossrefType "journal-article" @default.
- W2999696321 hasAuthorship W2999696321A5027814734 @default.