FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999703521> ?p ?o ?g. }

• W2999703521 endingPage "1108" @default.
• W2999703521 startingPage "1098" @default.
• W2999703521 abstract "Abstract Fluc family fluoride channels are assembled as primitive antiparallel homodimers. Crystallographic studies revealed a cation bound at the center of the protein, where it is coordinated at the dimer interface by main chain carbonyl oxygen atoms from the midmembrane breaks in two corresponding transmembrane helices. Here, we show that this cation is a stably bound sodium ion, and although it is not a transported substrate, its presence is required for the channel to adopt an open, fluoride-conducting conformation. The interfacial site is selective for sodium over other cations, except for Li+, which competes with Na+ for binding, but does not support channel activity. The strictly structural role fulfilled by this sodium provides new context to understand the structures, mechanisms, and evolutionary origins of widespread Na+-coupled transporters." @default.
• W2999703521 created "2020-01-23" @default.
• W2999703521 creator A5018640288 @default.
• W2999703521 creator A5021509670 @default.
• W2999703521 creator A5039043180 @default.
• W2999703521 creator A5068490397 @default.
• W2999703521 date "2020-02-01" @default.
• W2999703521 modified "2023-10-12" @default.
• W2999703521 title "An Interfacial Sodium Ion is an Essential Structural Feature of Fluc Family Fluoride Channels" @default.
• W2999703521 cites W1893822674 @default.
• W2999703521 cites W1975715632 @default.
• W2999703521 cites W1982655352 @default.
• W2999703521 cites W1985176332 @default.
• W2999703521 cites W1990805205 @default.
• W2999703521 cites W2010745148 @default.
• W2999703521 cites W2010753961 @default.
• W2999703521 cites W2029296469 @default.
• W2999703521 cites W2029660620 @default.
• W2999703521 cites W2031664044 @default.
• W2999703521 cites W2033731839 @default.
• W2999703521 cites W2059131094 @default.
• W2999703521 cites W2091125057 @default.
• W2999703521 cites W2100945678 @default.
• W2999703521 cites W2104622728 @default.
• W2999703521 cites W2188936358 @default.
• W2999703521 cites W2328111620 @default.
• W2999703521 cites W2331349292 @default.
• W2999703521 cites W2335250867 @default.
• W2999703521 cites W2409863258 @default.
• W2999703521 cites W2475459768 @default.
• W2999703521 cites W2487933339 @default.
• W2999703521 cites W2593905542 @default.
• W2999703521 cites W2613619836 @default.
• W2999703521 cites W2757302566 @default.
• W2999703521 cites W2786773105 @default.
• W2999703521 cites W2791543395 @default.
• W2999703521 cites W2793343697 @default.
• W2999703521 cites W2796124297 @default.
• W2999703521 cites W2808791900 @default.
• W2999703521 cites W2898508770 @default.
• W2999703521 cites W2940516695 @default.
• W2999703521 cites W2977535769 @default.
• W2999703521 cites W4232999647 @default.
• W2999703521 doi "https://doi.org/10.1016/j.jmb.2020.01.007" @default.
• W2999703521 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7054162" @default.
• W2999703521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31945374" @default.
• W2999703521 hasPublicationYear "2020" @default.
• W2999703521 type Work @default.
• W2999703521 sameAs 2999703521 @default.
• W2999703521 citedByCount "13" @default.
• W2999703521 countsByYear W29997035212020 @default.
• W2999703521 countsByYear W29997035212021 @default.
• W2999703521 countsByYear W29997035212022 @default.
• W2999703521 countsByYear W29997035212023 @default.
• W2999703521 crossrefType "journal-article" @default.
• W2999703521 hasAuthorship W2999703521A5018640288 @default.
• W2999703521 hasAuthorship W2999703521A5021509670 @default.
• W2999703521 hasAuthorship W2999703521A5039043180 @default.
• W2999703521 hasAuthorship W2999703521A5068490397 @default.
• W2999703521 hasBestOaLocation W29997035211 @default.
• W2999703521 hasConcept C12554922 @default.
• W2999703521 hasConcept C138885662 @default.
• W2999703521 hasConcept C145148216 @default.
• W2999703521 hasConcept C170493617 @default.
• W2999703521 hasConcept C178790620 @default.
• W2999703521 hasConcept C179104552 @default.
• W2999703521 hasConcept C185592680 @default.
• W2999703521 hasConcept C2776401178 @default.
• W2999703521 hasConcept C2779234887 @default.
• W2999703521 hasConcept C2780828025 @default.
• W2999703521 hasConcept C41895202 @default.
• W2999703521 hasConcept C50254741 @default.
• W2999703521 hasConcept C50952357 @default.
• W2999703521 hasConcept C537181965 @default.
• W2999703521 hasConcept C55493867 @default.
• W2999703521 hasConcept C86803240 @default.
• W2999703521 hasConceptScore W2999703521C12554922 @default.
• W2999703521 hasConceptScore W2999703521C138885662 @default.
• W2999703521 hasConceptScore W2999703521C145148216 @default.
• W2999703521 hasConceptScore W2999703521C170493617 @default.
• W2999703521 hasConceptScore W2999703521C178790620 @default.
• W2999703521 hasConceptScore W2999703521C179104552 @default.
• W2999703521 hasConceptScore W2999703521C185592680 @default.
• W2999703521 hasConceptScore W2999703521C2776401178 @default.
• W2999703521 hasConceptScore W2999703521C2779234887 @default.
• W2999703521 hasConceptScore W2999703521C2780828025 @default.
• W2999703521 hasConceptScore W2999703521C41895202 @default.
• W2999703521 hasConceptScore W2999703521C50254741 @default.
• W2999703521 hasConceptScore W2999703521C50952357 @default.
• W2999703521 hasConceptScore W2999703521C537181965 @default.
• W2999703521 hasConceptScore W2999703521C55493867 @default.
• W2999703521 hasConceptScore W2999703521C86803240 @default.
• W2999703521 hasFunder F4320306076 @default.
• W2999703521 hasFunder F4320306151 @default.
• W2999703521 hasFunder F4320332161 @default.
• W2999703521 hasIssue "4" @default.
• W2999703521 hasLocation W29997035211 @default.
• W2999703521 hasLocation W29997035212 @default.

• next