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• W2999705924 abstract "Despite subjects with Dominantly-Inherited Alzheimer's Disease (DIAD) represent less than 1% of all Alzheimer's Disease (AD) cases, the Dominantly Inherited Alzheimer Network (DIAN) initiative constitutes a strong impact in the understanding of AD disease course with special emphasis on the presyptomatic disease phase. Until now, the 3 genes involved in DIAD pathogenesis (PSEN1, PSEN2 and APP) have been commonly merged into one group (Mutation Carriers, MC) and studied using conventional statistical analysis. Comparisons between groups using null-hypothesis testing or longitudinal regression procedures, such as the linear-mixed-effects models, have been assessed in the extant literature. Within this context, the work presented here performs a comparison between different groups of subjects by considering the 3 genes, either jointly or separately, and using tools based on Machine Learning (ML). This involves a feature selection step which makes use of ANOVA followed by Principal Component Analysis (PCA) to determine which features would be realiable for further comparison purposes. Then, the selected predictors are classified using a Support-Vector-Machine (SVM) in a nested k-Fold cross-validation resulting in maximum classification rates of 72-74% using PiB PET features, specially when comparing asymptomatic Non-Carriers (NC) subjects with asymptomatic PSEN1 Mutation-Carriers (PSEN1-MC). Results obtained from these experiments led to the idea that PSEN1-MC might be considered as a mixture of two different subgroups including: a first group whose patterns were very close to NC subjects, and a second group much more different in terms of imaging patterns. Thus, using a k-Means clustering algorithm it was determined both subgroups and a new classification scenario was conducted to validate this process. The comparison between each subgroup vs. NC subjects resulted in classification rates around 80% underscoring the importance of considering DIAN as an heterogeneous entity." @default.
• W2999705924 created "2020-01-23" @default.
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• W2999705924 date "2020-06-01" @default.
• W2999705924 modified "2023-10-01" @default.
• W2999705924 title "Autosomal dominantly inherited alzheimer disease: Analysis of genetic subgroups by machine learning" @default.
• W2999705924 cites W1515586143 @default.
• W2999705924 cites W1522806115 @default.
• W2999705924 cites W1546597559 @default.
• W2999705924 cites W1616122655 @default.
• W2999705924 cites W1993571512 @default.
• W2999705924 cites W1995362795 @default.
• W2999705924 cites W2001854231 @default.
• W2999705924 cites W2002171347 @default.
• W2999705924 cites W2002414308 @default.
• W2999705924 cites W2004293194 @default.
• W2999705924 cites W2008152557 @default.
• W2999705924 cites W2023381648 @default.
• W2999705924 cites W2031425398 @default.
• W2999705924 cites W2031881208 @default.
• W2999705924 cites W2041070093 @default.
• W2999705924 cites W2046209489 @default.
• W2999705924 cites W2046613542 @default.
• W2999705924 cites W2047301935 @default.
• W2999705924 cites W2053288220 @default.
• W2999705924 cites W2063272219 @default.
• W2999705924 cites W2074925665 @default.
• W2999705924 cites W2083633251 @default.
• W2999705924 cites W2086316204 @default.
• W2999705924 cites W2086523105 @default.
• W2999705924 cites W2089468765 @default.
• W2999705924 cites W2090533051 @default.
• W2999705924 cites W2093198322 @default.
• W2999705924 cites W2096695700 @default.
• W2999705924 cites W2096890121 @default.
• W2999705924 cites W2101135654 @default.
• W2999705924 cites W2108474398 @default.
• W2999705924 cites W2108493635 @default.
• W2999705924 cites W2110208125 @default.
• W2999705924 cites W2110437310 @default.
• W2999705924 cites W2110630889 @default.
• W2999705924 cites W2111425471 @default.
• W2999705924 cites W2113319997 @default.
• W2999705924 cites W2116964904 @default.
• W2999705924 cites W2119774197 @default.
• W2999705924 cites W2121369614 @default.
• W2999705924 cites W2127324977 @default.
• W2999705924 cites W2129497119 @default.
• W2999705924 cites W2134310798 @default.
• W2999705924 cites W2139484908 @default.
• W2999705924 cites W2139886607 @default.
• W2999705924 cites W2142635246 @default.
• W2999705924 cites W2144021643 @default.
• W2999705924 cites W2145003996 @default.
• W2999705924 cites W2146875154 @default.
• W2999705924 cites W2151130155 @default.
• W2999705924 cites W2151721316 @default.
• W2999705924 cites W2152163581 @default.
• W2999705924 cites W2154067471 @default.
• W2999705924 cites W2155963684 @default.
• W2999705924 cites W2157270343 @default.
• W2999705924 cites W2163958074 @default.
• W2999705924 cites W2167840686 @default.
• W2999705924 cites W2171250577 @default.
• W2999705924 cites W2205982756 @default.
• W2999705924 cites W2309442902 @default.
• W2999705924 cites W2309640507 @default.
• W2999705924 cites W2316313792 @default.
• W2999705924 cites W2324271630 @default.
• W2999705924 cites W2518195265 @default.
• W2999705924 cites W2535940399 @default.
• W2999705924 cites W2538894230 @default.
• W2999705924 cites W2567168289 @default.
• W2999705924 cites W2774489999 @default.
• W2999705924 cites W2775029084 @default.
• W2999705924 cites W2791743234 @default.
• W2999705924 cites W2794133158 @default.
• W2999705924 cites W2795733020 @default.
• W2999705924 cites W2798054687 @default.
• W2999705924 cites W2902620820 @default.
• W2999705924 cites W2928936484 @default.

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