FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999728635> ?p ?o ?g. }

• W2999728635 abstract "Endeavors towards identifying key molecular markers for early diagnosis and treatment are driving the clinical study of papillary thyroid carcinoma (PTC). Recent studies have indicated that protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) exerts an oncogenic function by increasing cell proliferation, migration and invasion in various cancer types. In addition, PPM1D has a high frequency of genetic alterations and has been proposed as a tumor driver in thyroid cancer, making PPM1D an attractive potential oncotarget for cancer treatment. The aims of the present study were to investigate the downstream targets of PPM1D and the potential molecular mechanisms of its oncogenic activities, as well as its clinical significance in PTC. As anticipated, PPM1D overexpression was confirmed in PTC clinical specimens. Furthermore, knockdown of PPM1D in thyroid cancer cell lines significantly suppressed the proliferation, migration and invasion but facilitated cell apoptosis. The protein levels of phosphorylated p38 mitogen‑activated protein kinase (MAPK), p53 and Bax were increased in PPM1D‑knockdown cells, while inhibition of p38 phosphorylation restored cell migration, proliferation and cell apoptosis. In addition, silencing of PPM1D expression induced nuclear translocation of p53 in K‑1 and TPC‑1 cells. The present results demonstrated that PPM1D regulated p38 MAPK and p53 signaling pathways to promote thyroid cancer progression. Collectively with the clinical results, these data qualified PPM1D as a potential diagnostic biomarker and therapeutic target in human thyroid cancer." @default.
• W2999728635 created "2020-01-23" @default.
• W2999728635 creator A5003237525 @default.
• W2999728635 creator A5010532818 @default.
• W2999728635 creator A5017232479 @default.
• W2999728635 creator A5019447258 @default.
• W2999728635 creator A5031759097 @default.
• W2999728635 creator A5032318104 @default.
• W2999728635 creator A5063629840 @default.
• W2999728635 creator A5082821930 @default.
• W2999728635 date "2020-01-09" @default.
• W2999728635 modified "2023-09-29" @default.
• W2999728635 title "Silencing of PPM1D inhibits cell proliferation and invasion through the p38�MAPK and p53 signaling pathway in papillary thyroid carcinoma" @default.
• W2999728635 cites W1848939527 @default.
• W2999728635 cites W1966784294 @default.
• W2999728635 cites W1966916880 @default.
• W2999728635 cites W1969524738 @default.
• W2999728635 cites W1972779889 @default.
• W2999728635 cites W1976973627 @default.
• W2999728635 cites W1979786191 @default.
• W2999728635 cites W1998662823 @default.
• W2999728635 cites W2011729787 @default.
• W2999728635 cites W2019047723 @default.
• W2999728635 cites W2027573197 @default.
• W2999728635 cites W2039030772 @default.
• W2999728635 cites W2040169548 @default.
• W2999728635 cites W2054208935 @default.
• W2999728635 cites W2060630008 @default.
• W2999728635 cites W2068127752 @default.
• W2999728635 cites W2069175122 @default.
• W2999728635 cites W2075811389 @default.
• W2999728635 cites W2084472730 @default.
• W2999728635 cites W2088308108 @default.
• W2999728635 cites W2113563170 @default.
• W2999728635 cites W2137828039 @default.
• W2999728635 cites W2148720931 @default.
• W2999728635 cites W2162369786 @default.
• W2999728635 cites W2276656727 @default.
• W2999728635 cites W2279570938 @default.
• W2999728635 cites W2511227446 @default.
• W2999728635 cites W2791324985 @default.
• W2999728635 cites W3029035991 @default.
• W2999728635 doi "https://doi.org/10.3892/or.2020.7458" @default.
• W2999728635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7040886" @default.
• W2999728635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31922231" @default.
• W2999728635 hasPublicationYear "2020" @default.
• W2999728635 type Work @default.
• W2999728635 sameAs 2999728635 @default.
• W2999728635 citedByCount "3" @default.
• W2999728635 countsByYear W29997286352020 @default.
• W2999728635 countsByYear W29997286352022 @default.
• W2999728635 crossrefType "journal-article" @default.
• W2999728635 hasAuthorship W2999728635A5003237525 @default.
• W2999728635 hasAuthorship W2999728635A5010532818 @default.
• W2999728635 hasAuthorship W2999728635A5017232479 @default.
• W2999728635 hasAuthorship W2999728635A5019447258 @default.
• W2999728635 hasAuthorship W2999728635A5031759097 @default.
• W2999728635 hasAuthorship W2999728635A5032318104 @default.
• W2999728635 hasAuthorship W2999728635A5063629840 @default.
• W2999728635 hasAuthorship W2999728635A5082821930 @default.
• W2999728635 hasBestOaLocation W29997286351 @default.
• W2999728635 hasConcept C104317684 @default.
• W2999728635 hasConcept C119056186 @default.
• W2999728635 hasConcept C121608353 @default.
• W2999728635 hasConcept C173396325 @default.
• W2999728635 hasConcept C190283241 @default.
• W2999728635 hasConcept C2779761222 @default.
• W2999728635 hasConcept C2781018059 @default.
• W2999728635 hasConcept C29537977 @default.
• W2999728635 hasConcept C502942594 @default.
• W2999728635 hasConcept C54355233 @default.
• W2999728635 hasConcept C55493867 @default.
• W2999728635 hasConcept C57074206 @default.
• W2999728635 hasConcept C62112901 @default.
• W2999728635 hasConcept C62478195 @default.
• W2999728635 hasConcept C86803240 @default.
• W2999728635 hasConcept C95444343 @default.
• W2999728635 hasConcept C96232424 @default.
• W2999728635 hasConceptScore W2999728635C104317684 @default.
• W2999728635 hasConceptScore W2999728635C119056186 @default.
• W2999728635 hasConceptScore W2999728635C121608353 @default.
• W2999728635 hasConceptScore W2999728635C173396325 @default.
• W2999728635 hasConceptScore W2999728635C190283241 @default.
• W2999728635 hasConceptScore W2999728635C2779761222 @default.
• W2999728635 hasConceptScore W2999728635C2781018059 @default.
• W2999728635 hasConceptScore W2999728635C29537977 @default.
• W2999728635 hasConceptScore W2999728635C502942594 @default.
• W2999728635 hasConceptScore W2999728635C54355233 @default.
• W2999728635 hasConceptScore W2999728635C55493867 @default.
• W2999728635 hasConceptScore W2999728635C57074206 @default.
• W2999728635 hasConceptScore W2999728635C62112901 @default.
• W2999728635 hasConceptScore W2999728635C62478195 @default.
• W2999728635 hasConceptScore W2999728635C86803240 @default.
• W2999728635 hasConceptScore W2999728635C95444343 @default.
• W2999728635 hasConceptScore W2999728635C96232424 @default.
• W2999728635 hasLocation W29997286351 @default.
• W2999728635 hasLocation W29997286352 @default.
• W2999728635 hasLocation W29997286353 @default.
• W2999728635 hasLocation W29997286354 @default.
• W2999728635 hasOpenAccess W2999728635 @default.

• next