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- W2999737340 abstract "ABSTRACT Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of inaccessible human cell types, yielding new insights into disease mechanisms especially for neurological disorders. However, without due consideration, the thousands of new human iPSC lines generated in the past decade will inevitably affect the reproducibility of iPSC-based experiments. Differences between donor individuals, genetic stability and experimental variability contribute to iPSC model variation by impacting differentiation potency, cellular heterogeneity, morphology, and transcript and protein abundance. Such effects will confound reproducible disease modelling in the absence of appropriate strategies. In this Review, we explore the causes and effects of iPSC heterogeneity, and propose approaches to detect and account for experimental variation between studies, or even exploit it for deeper biological insight." @default.
- W2999737340 created "2020-01-23" @default.
- W2999737340 creator A5029013428 @default.
- W2999737340 creator A5085143207 @default.
- W2999737340 date "2020-01-01" @default.
- W2999737340 modified "2023-10-14" @default.
- W2999737340 title "Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility" @default.
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- W2999737340 cites W1671213273 @default.
- W2999737340 cites W1984512942 @default.
- W2999737340 cites W1996076770 @default.
- W2999737340 cites W2008485310 @default.
- W2999737340 cites W2010653277 @default.
- W2999737340 cites W2039521726 @default.
- W2999737340 cites W2041118365 @default.
- W2999737340 cites W2058256214 @default.
- W2999737340 cites W2062872865 @default.
- W2999737340 cites W2064815984 @default.
- W2999737340 cites W2073610802 @default.
- W2999737340 cites W2081460627 @default.
- W2999737340 cites W2087252982 @default.
- W2999737340 cites W2088797184 @default.
- W2999737340 cites W2097981742 @default.
- W2999737340 cites W2102424187 @default.
- W2999737340 cites W2126231259 @default.
- W2999737340 cites W2129164922 @default.
- W2999737340 cites W2139372806 @default.
- W2999737340 cites W2144208823 @default.
- W2999737340 cites W2144993965 @default.
- W2999737340 cites W2155734183 @default.
- W2999737340 cites W2161210583 @default.
- W2999737340 cites W2179324930 @default.
- W2999737340 cites W2263947150 @default.
- W2999737340 cites W2274884200 @default.
- W2999737340 cites W2281703724 @default.
- W2999737340 cites W2336999086 @default.
- W2999737340 cites W2419046874 @default.
- W2999737340 cites W2500581099 @default.
- W2999737340 cites W2508829585 @default.
- W2999737340 cites W2528382567 @default.
- W2999737340 cites W2528543174 @default.
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- W2999737340 cites W2560342620 @default.
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- W2999737340 cites W2605339538 @default.
- W2999737340 cites W2607261398 @default.
- W2999737340 cites W2608500349 @default.
- W2999737340 cites W2613179652 @default.
- W2999737340 cites W2614924988 @default.
- W2999737340 cites W2618676107 @default.
- W2999737340 cites W2622214442 @default.
- W2999737340 cites W2623260545 @default.
- W2999737340 cites W2737212444 @default.
- W2999737340 cites W2747850876 @default.
- W2999737340 cites W2761186974 @default.
- W2999737340 cites W2765727943 @default.
- W2999737340 cites W2786189816 @default.
- W2999737340 cites W2788963675 @default.
- W2999737340 cites W2789041035 @default.
- W2999737340 cites W2791400496 @default.
- W2999737340 cites W2803649084 @default.
- W2999737340 cites W2808575536 @default.
- W2999737340 cites W2824445991 @default.
- W2999737340 cites W2883480695 @default.
- W2999737340 cites W2884305074 @default.
- W2999737340 cites W2889807039 @default.
- W2999737340 cites W2892091513 @default.
- W2999737340 cites W2897544150 @default.
- W2999737340 cites W2900817023 @default.
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- W2999737340 cites W2906812748 @default.
- W2999737340 cites W2912993019 @default.
- W2999737340 cites W2915808837 @default.
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- W2999737340 cites W2945415170 @default.
- W2999737340 cites W2946108640 @default.
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- W2999737340 cites W2951666765 @default.
- W2999737340 cites W2952240309 @default.
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- W2999737340 doi "https://doi.org/10.1242/dmm.042317" @default.
- W2999737340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6994963" @default.
- W2999737340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31953356" @default.
- W2999737340 hasPublicationYear "2020" @default.
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