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- W2999872015 abstract "ABSTRACT Introduction Prediction of rectal cancer response to preoperative, neo-adjuvant chemo-radiation therapy (CRT) provides the opportunity to identify patients in whom a major response is expected and who may therefore benefit from alternative surgical approaches. Traditional morphological imaging techniques are effective in defining tumour extension in the initial diagnostic and staging work-up, but perform poorly in distinguishing residual neoplastic tissue from scarring post CRT, when restaging the patient before surgery. Fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) is a promising tool for monitoring the effect of anti-tumour therapy. The aim of this study was to prospectively assess the value of sequential FDG-PET scans in predicting the response of locally advanced rectal cancer to neo-adjuvant CRT. Methods 42 patients with locally advance rectal cancer who undergo a neo-adjuvant therapy are included in this study. All patients received chemoradiotherapy treatment. PET-TAC was performed before and six weeks after completion of preoperative neo- adjuvant protocol. Surgical resection included of total mesorectal excision. PET- TAC parameters included maximum standard uptake value (SUV max) and the mean percentage decrease in SUV max. Results were correlated with pathological response, assessed both by histopathological staging of the surgical specimens (pTNM). In all patients the primary lesions showed high SUV max (SUV max 13.14 +/-5). Following neo-adjuvant CRT, of the 42 patients submitted to surgery, 37 patients (88.1%)were classified as responders with relevant decreasing in FDG uptake (75% +/- 25%) while the remaining 5 patients (11.9%) were non-responders. After neo-adjuvant therapy 5 patients (11.9%) showed negative PET-TAC, with complete pathological remission and tumor absence in primary local in 3 patients and 2 patients had partial pathological remission. After neo-adjuvant therapy 32 patients (76.1%) showed decrease in Suv max and16 patients presented partial pathological remission, with a correlation of 84.2% between decrease in Suv max and partial pathological remission of total patients. Conclusion The results suggest the potential utility of FDG-PET as a complementary diagnostic and prognostic procedure in the assessment of neo-adjuvant CRT response of locally advanced rectal cancer. SUV(max) seem the best predictor of CRT response." @default.
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- W2999872015 date "2012-06-01" @default.
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- W2999872015 title "PD-0007 18F-Fdg Positron Emission Tomography (FDG-PET) and Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer" @default.
- W2999872015 doi "https://doi.org/10.1016/s0923-7534(19)66501-4" @default.
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