Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999888918> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2999888918 abstract "Abstract Background The prevalence of inflammatory bowel disease (IBD) has increased dramatically in recent years, particularly in paediatric populations. The efficacy of available therapies is limited and often transient, leading patients to seek alternative therapies for symptom relief, including the use of medical marijuana (Cannabis sativa). There is some evidence to suggest that cannabinoids exert anti-inflammatory effects in preclinical colitis models. In addition, a number of small studies have reported improvements in non-empirical disease measures and reductions in visceral pain in response to cannabis use. However, associations between cannabis use in IBD and increased need for surgical interventions have also been reported. Methods Therefore, determining the direct impact of cannabis use on immune modulation in IBD patients is of critical importance. Blood samples collected from paediatric IBD patients who reported cannabis use for symptom control were analysed for cytokine expression and T-cell signalling pathway activation compared with non-users. Concentrations of serum phytocannabinoids were determined by HPLC and correlated with subsequent ex vivo assay parameters. Results Results demonstrated elevated levels of a myriad of pro-inflammatory cytokines in users vs. non-users upon ex vivo restimulation. This coincided with an expansion of pathogenic Th17 cells in the periphery. Differences in signalling cascades of activated T cells between users and non-users were also observed. Conclusion These results suggest that cannabis exposure, which can desensitise cannabinoid receptors, may prime pro-inflammatory pathways in paediatric IBD patients. Future studies should address the limitations of observational studies through the use of randomised controlled trials of cannabis use in paediatric IBD populations. This research was funded by the Colorado Department of Public Health and Environment." @default.
- W2999888918 created "2020-01-23" @default.
- W2999888918 creator A5004453414 @default.
- W2999888918 creator A5033642821 @default.
- W2999888918 creator A5042292777 @default.
- W2999888918 creator A5071109701 @default.
- W2999888918 creator A5081612817 @default.
- W2999888918 creator A5091076691 @default.
- W2999888918 date "2020-01-01" @default.
- W2999888918 modified "2023-09-27" @default.
- W2999888918 title "P084 Cannabis use promotes lymphocyte responsiveness and modifies T-cell signalling in adolescent IBD patients" @default.
- W2999888918 doi "https://doi.org/10.1093/ecco-jcc/jjz203.213" @default.
- W2999888918 hasPublicationYear "2020" @default.
- W2999888918 type Work @default.
- W2999888918 sameAs 2999888918 @default.
- W2999888918 citedByCount "0" @default.
- W2999888918 crossrefType "journal-article" @default.
- W2999888918 hasAuthorship W2999888918A5004453414 @default.
- W2999888918 hasAuthorship W2999888918A5033642821 @default.
- W2999888918 hasAuthorship W2999888918A5042292777 @default.
- W2999888918 hasAuthorship W2999888918A5071109701 @default.
- W2999888918 hasAuthorship W2999888918A5081612817 @default.
- W2999888918 hasAuthorship W2999888918A5091076691 @default.
- W2999888918 hasBestOaLocation W29998889181 @default.
- W2999888918 hasConcept C118552586 @default.
- W2999888918 hasConcept C126322002 @default.
- W2999888918 hasConcept C150903083 @default.
- W2999888918 hasConcept C170493617 @default.
- W2999888918 hasConcept C203014093 @default.
- W2999888918 hasConcept C207001950 @default.
- W2999888918 hasConcept C26291073 @default.
- W2999888918 hasConcept C2776895053 @default.
- W2999888918 hasConcept C2777056318 @default.
- W2999888918 hasConcept C2778260677 @default.
- W2999888918 hasConcept C2779134260 @default.
- W2999888918 hasConcept C2780871563 @default.
- W2999888918 hasConcept C71924100 @default.
- W2999888918 hasConcept C86803240 @default.
- W2999888918 hasConceptScore W2999888918C118552586 @default.
- W2999888918 hasConceptScore W2999888918C126322002 @default.
- W2999888918 hasConceptScore W2999888918C150903083 @default.
- W2999888918 hasConceptScore W2999888918C170493617 @default.
- W2999888918 hasConceptScore W2999888918C203014093 @default.
- W2999888918 hasConceptScore W2999888918C207001950 @default.
- W2999888918 hasConceptScore W2999888918C26291073 @default.
- W2999888918 hasConceptScore W2999888918C2776895053 @default.
- W2999888918 hasConceptScore W2999888918C2777056318 @default.
- W2999888918 hasConceptScore W2999888918C2778260677 @default.
- W2999888918 hasConceptScore W2999888918C2779134260 @default.
- W2999888918 hasConceptScore W2999888918C2780871563 @default.
- W2999888918 hasConceptScore W2999888918C71924100 @default.
- W2999888918 hasConceptScore W2999888918C86803240 @default.
- W2999888918 hasLocation W29998889181 @default.
- W2999888918 hasOpenAccess W2999888918 @default.
- W2999888918 hasPrimaryLocation W29998889181 @default.
- W2999888918 hasRelatedWork W10373796 @default.
- W2999888918 hasRelatedWork W1128471 @default.
- W2999888918 hasRelatedWork W1214524 @default.
- W2999888918 hasRelatedWork W385456 @default.
- W2999888918 hasRelatedWork W4198340 @default.
- W2999888918 hasRelatedWork W6341581 @default.
- W2999888918 hasRelatedWork W6736550 @default.
- W2999888918 hasRelatedWork W6983041 @default.
- W2999888918 hasRelatedWork W7080273 @default.
- W2999888918 hasRelatedWork W7609407 @default.
- W2999888918 isParatext "false" @default.
- W2999888918 isRetracted "false" @default.
- W2999888918 magId "2999888918" @default.
- W2999888918 workType "article" @default.