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• W2999911778 abstract "Abstract Conduction of action potentials along nerve fiber is an important nonlinear phenomenon related to neural information transition. Recently, the conduction failure behavior that some action potentials with high frequency fail to conduct along C-fiber was identified to be associated with diabetic neuropathy and induced by potassium (K+) channel. In the present paper, the dynamical mechanism for downregulated expression of K+ channel induced-reduction of conduction failure, i.e. enhancement of painful information, is acquired with a chain network model composed of Hodgkin-Huxley (HH) neurons. The conduction failure behavior appears for the action potentials induced by stimulation with high frequency and small coupling strength corresponding to C-fiber, and the conduction failure degree reduces with decreasing K+ conductance, which closely matches with those observed in the biological experiment. Moreover, the dynamics of the conduction failure behavior are explained with the Hopf bifurcation of HH model. The afterpotential near the Hopf bifurcation exhibits the damping oscillation, which leads to that the current intensity threshold of a pulse stimulation to evoke an action potential from the afterpotential also manifests damping oscillations. Such a current threshold is the intrinsic cause that conduction failure behavior appears for action potential with high frequency. With decreasing K+ conductance, the current threshold becomes lower, which is the intrinsic dynamical mechanism for the reduction of conduction failure degree. By using current threshold determined by Hopf bifurcation, the results present the dynamical mechanism of potassium channel induced-conduction failure behavior, which shows that potassium channel is a potential modulation candidate for the pathological pain." @default.
• W2999911778 created "2020-01-23" @default.
• W2999911778 creator A5054828026 @default.
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• W2999911778 date "2020-04-01" @default.
• W2999911778 modified "2023-10-08" @default.
• W2999911778 title "Dynamical mechanism for conduction failure behavior of action potentials related to pain information transmission" @default.
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• W2999911778 doi "https://doi.org/10.1016/j.neucom.2019.12.114" @default.
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