FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2999929165> ?p ?o ?g. }

• W2999929165 endingPage "57" @default.
• W2999929165 startingPage "46" @default.
• W2999929165 abstract "Background: Chitinases are the evolutionary conserved glycosidic enzymes that are characterized by their ability to cleave the naturally abundant polysaccharide chitin. The potential role of chitinases has been identified in the manifestation of various allergies and inflammatory diseases. In recent years, chitinases inhibitors are emerging as an alluring area of interest for the researchers and scientists and there is a dire need for the development of potential and safe chitinase antagonists for the prophylaxis and treatment of several diseases. Objective: The present review expedites the role of chitinases and their inhibitors in inflammation and related disorders. Methods: At first, an exhaustive survey of literature and various patents available related to chitinases were carried out. Useful information on chitinases and their inhibitor was gathered from the authentic scientific databases namely SCOPUS, EMBASE, PUBMED, GOOGLE SCHOLAR, MEDLINE, EMBASE, EBSCO, WEB OF SCIENCE, etc. This information was further analyzed and compiled up to prepare the framework of the review article. The search strategy was conducted by using queries with key terms “ chitin”, “chitinase”, “chitotrisidase”, “acidic mammalian chitinase”, “chitinase inhibitors”, “asthma” and “chitinases associated inflammatory disorders”, etc. The patents were searched using the key terms “chitinases and uses thereof”, “chitinase inhibitors”, “chitin-chitinase associated pathological disorders” etc. from www.google.com/patents, www.freepatentsonline.com, and www.scopus.com. Results: The present review provides a vision for apprehending human chitinases and their participation in several diseases. The patents available also signify the extended role and effectiveness of chitinase inhibitors in the prevention and treatment of various diseases viz. asthma, acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer. In this regard, extensive pre-clinical and clinical investigations are required to develop some novel, potent and selective drug molecules for the treatment of various inflammatory diseases, allergies and cancers in the foreseeable future. Conclusion: In conclusion, chitinases can be used as potential biomarkers in prognosis and diagnosis of several inflammatory diseases and allergies and the design of novel chitinase inhibitors may act as key and rational scaffolds in designing some novel therapeutic agents in the treatment of variety of inflammatory diseases." @default.
• W2999929165 created "2020-01-23" @default.
• W2999929165 creator A5049756208 @default.
• W2999929165 creator A5061735265 @default.
• W2999929165 creator A5082281202 @default.
• W2999929165 creator A5090044182 @default.
• W2999929165 date "2020-03-30" @default.
• W2999929165 modified "2023-09-23" @default.
• W2999929165 title "Chitinases: Therapeutic Scaffolds for Allergy and Inflammation" @default.
• W2999929165 cites W1536685239 @default.
• W2999929165 cites W1568609804 @default.
• W2999929165 cites W1577955674 @default.
• W2999929165 cites W1772341111 @default.
• W2999929165 cites W1780849736 @default.
• W2999929165 cites W1869380658 @default.
• W2999929165 cites W1975634640 @default.
• W2999929165 cites W1980701408 @default.
• W2999929165 cites W1982945664 @default.
• W2999929165 cites W1985871023 @default.
• W2999929165 cites W1989344768 @default.
• W2999929165 cites W1994721840 @default.
• W2999929165 cites W1996453536 @default.
• W2999929165 cites W1999206690 @default.
• W2999929165 cites W2003176514 @default.
• W2999929165 cites W2004842120 @default.
• W2999929165 cites W2005361432 @default.
• W2999929165 cites W2007954503 @default.
• W2999929165 cites W2016435897 @default.
• W2999929165 cites W2020469699 @default.
• W2999929165 cites W2021291917 @default.
• W2999929165 cites W2021696672 @default.
• W2999929165 cites W2025131995 @default.
• W2999929165 cites W2035989157 @default.
• W2999929165 cites W2036178956 @default.
• W2999929165 cites W2037711371 @default.
• W2999929165 cites W2038971761 @default.
• W2999929165 cites W2046118166 @default.
• W2999929165 cites W2055280186 @default.
• W2999929165 cites W2055968806 @default.
• W2999929165 cites W2064137116 @default.
• W2999929165 cites W2072705074 @default.
• W2999929165 cites W2075045438 @default.
• W2999929165 cites W2075858546 @default.
• W2999929165 cites W2084045035 @default.
• W2999929165 cites W2084902225 @default.
• W2999929165 cites W2085266981 @default.
• W2999929165 cites W2086878983 @default.
• W2999929165 cites W2087114667 @default.
• W2999929165 cites W2089678908 @default.
• W2999929165 cites W2090919511 @default.
• W2999929165 cites W2091844375 @default.
• W2999929165 cites W2092501876 @default.
• W2999929165 cites W2099556150 @default.
• W2999929165 cites W2103826062 @default.
• W2999929165 cites W2105248725 @default.
• W2999929165 cites W2106083621 @default.
• W2999929165 cites W2111816511 @default.
• W2999929165 cites W2113269708 @default.
• W2999929165 cites W2117056069 @default.
• W2999929165 cites W2120641909 @default.
• W2999929165 cites W2121775309 @default.
• W2999929165 cites W2127829790 @default.
• W2999929165 cites W2130701697 @default.
• W2999929165 cites W2134194234 @default.
• W2999929165 cites W2136028521 @default.
• W2999929165 cites W2138893896 @default.
• W2999929165 cites W2142288208 @default.
• W2999929165 cites W2144456776 @default.
• W2999929165 cites W2146859436 @default.
• W2999929165 cites W2148377603 @default.
• W2999929165 cites W2160657145 @default.
• W2999929165 cites W2160806937 @default.
• W2999929165 cites W2162870516 @default.
• W2999929165 cites W2171612234 @default.
• W2999929165 cites W2191098263 @default.
• W2999929165 cites W2192396444 @default.
• W2999929165 cites W2201787692 @default.
• W2999929165 cites W2226913284 @default.
• W2999929165 cites W2300812187 @default.
• W2999929165 cites W2325624449 @default.
• W2999929165 cites W2514609206 @default.
• W2999929165 cites W2577063270 @default.
• W2999929165 cites W2598456180 @default.
• W2999929165 cites W2766019204 @default.
• W2999929165 cites W2802619322 @default.
• W2999929165 cites W2804899503 @default.
• W2999929165 cites W2950186052 @default.
• W2999929165 cites W59921735 @default.
• W2999929165 doi "https://doi.org/10.2174/1872213x14666200114184054" @default.
• W2999929165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7509760" @default.
• W2999929165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31934842" @default.
• W2999929165 hasPublicationYear "2020" @default.
• W2999929165 type Work @default.
• W2999929165 sameAs 2999929165 @default.
• W2999929165 citedByCount "4" @default.
• W2999929165 countsByYear W29999291652021 @default.
• W2999929165 countsByYear W29999291652022 @default.
• W2999929165 countsByYear W29999291652023 @default.

• next