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• W2999971237 endingPage "126" @default.
• W2999971237 startingPage "114" @default.
• W2999971237 abstract "Aluminum compounds have been observed in various brain regions, and their accumulation has been associated with many neurodegenerative disorders. Neurotoxic effects of aluminum are attributed to reactive oxygen species generation, induction of apoptosis and inflammatory reactions activation. Metalloestrogen activity of aluminum has also been linked to breast cancer progression and metastasis. In this study, taking into account the anti-apoptotic and anti-oxidant activities of estrogens in neuronal cells, which are mediated by estrogen receptors, the possible estrogenic activity of aluminum in SH-SY5Y neuroblastoma cells was studied. Our results showed that aluminum in the form of aluminum chlorohydrate (ACH) exhibited no effect on estrogen receptors transcriptional activation, and differential effect on estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) protein levels. ACH caused reduction in ERβ protein levels, and increase in its mitochondrial localization. ACH-induced reduction in ERβ protein level may be linked, at least in part, to the ACH-induced increase in ERα protein level. This statement is based on our observations showing aluminum-induced reduction in the E2-induced increase in ERα S118 phosphorylation, in MCF-7 and SH-SH5Y cells. Phosphorylation at S118 residue is known to be associated with inhibition of the ubiquitin-induced proteolytic degradation of ERα, leading to its accumulation. Since it is known that ERα negatively regulate ERβ expression, increase in ERα, may contribute to reduction in ERβ levels and subsequent weakening of its anti-apoptotic and anti-oxidant activity, justified by the observed reduction in procaspase 9, mitochondrial cytochrome c, Bcl-2, Bcl-xL and mitochondrial thioredoxin protein level, as well as by the increase in proapoptotic BAX level, in ACH treated SH-SY5Y cells. In addition, increase in mitochondrial ERβ localization may also trigger mitochondrial metabolism, suppress biosynthetic process of gluconeogenesis, as indicated by the observed reduction in the phosphoenolpyruvate carboxykinase protein level, and eventually lead to increase in reactive oxygen species (ROS) generation, known to be implicated in aluminum induced neurodegeneration. This statement was verified by the observed ACH–induced increase in ERβ mitochondrial localization, induction of the mitochondrial membrane depolarization and increase in ROS production, in neuronal-like differentiated SH-SY5Y cells." @default.
• W2999971237 created "2020-01-23" @default.
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• W2999971237 creator A5088773506 @default.
• W2999971237 date "2020-03-01" @default.
• W2999971237 modified "2023-09-30" @default.
• W2999971237 title "Neurotoxic effects of aluminum are associated with its interference with estrogen receptors signaling" @default.
• W2999971237 cites W1465603094 @default.
• W2999971237 cites W153393150 @default.
• W2999971237 cites W1897134855 @default.
• W2999971237 cites W1963697539 @default.
• W2999971237 cites W1965846876 @default.
• W2999971237 cites W1971633703 @default.
• W2999971237 cites W1971754653 @default.
• W2999971237 cites W1987387393 @default.
• W2999971237 cites W1988614747 @default.
• W2999971237 cites W1990166384 @default.
• W2999971237 cites W1990576414 @default.
• W2999971237 cites W1997622817 @default.
• W2999971237 cites W2003216189 @default.
• W2999971237 cites W2015936699 @default.
• W2999971237 cites W2018103288 @default.
• W2999971237 cites W2021439150 @default.
• W2999971237 cites W2022125304 @default.
• W2999971237 cites W2023356552 @default.
• W2999971237 cites W2025002326 @default.
• W2999971237 cites W2026537644 @default.
• W2999971237 cites W2028677997 @default.
• W2999971237 cites W2029245044 @default.
• W2999971237 cites W2034578928 @default.
• W2999971237 cites W2039314515 @default.
• W2999971237 cites W2039879202 @default.
• W2999971237 cites W2042176328 @default.
• W2999971237 cites W2046082610 @default.
• W2999971237 cites W2049237430 @default.
• W2999971237 cites W2051606092 @default.
• W2999971237 cites W2052853582 @default.
• W2999971237 cites W2054939750 @default.
• W2999971237 cites W2058013358 @default.
• W2999971237 cites W2060404556 @default.
• W2999971237 cites W2062542032 @default.
• W2999971237 cites W2065008745 @default.
• W2999971237 cites W2065660996 @default.
• W2999971237 cites W2066298795 @default.
• W2999971237 cites W2069402380 @default.
• W2999971237 cites W2070422410 @default.
• W2999971237 cites W2073985171 @default.
• W2999971237 cites W2074728855 @default.
• W2999971237 cites W2076349576 @default.
• W2999971237 cites W2078175742 @default.
• W2999971237 cites W2096980628 @default.
• W2999971237 cites W2100043100 @default.
• W2999971237 cites W2100749283 @default.
• W2999971237 cites W2110928253 @default.
• W2999971237 cites W2123347941 @default.
• W2999971237 cites W2124697229 @default.
• W2999971237 cites W2129309010 @default.
• W2999971237 cites W2132527250 @default.
• W2999971237 cites W2134201969 @default.
• W2999971237 cites W2134674714 @default.
• W2999971237 cites W2139783987 @default.
• W2999971237 cites W2144463858 @default.
• W2999971237 cites W217426765 @default.
• W2999971237 cites W2225425584 @default.
• W2999971237 cites W2327813062 @default.
• W2999971237 cites W2330286114 @default.
• W2999971237 cites W2464101707 @default.
• W2999971237 cites W2481709804 @default.
• W2999971237 cites W2488345387 @default.
• W2999971237 cites W2509853338 @default.
• W2999971237 cites W2513947093 @default.
• W2999971237 cites W2528674264 @default.
• W2999971237 cites W2533915117 @default.
• W2999971237 cites W2546855403 @default.
• W2999971237 cites W2598753811 @default.
• W2999971237 cites W2605384809 @default.
• W2999971237 cites W2605571752 @default.
• W2999971237 cites W2613557015 @default.
• W2999971237 cites W2618988984 @default.
• W2999971237 cites W2674517454 @default.
• W2999971237 cites W2740441878 @default.
• W2999971237 cites W2767752220 @default.
• W2999971237 cites W2768313679 @default.
• W2999971237 cites W2770913560 @default.
• W2999971237 cites W2790435876 @default.
• W2999971237 cites W2804893668 @default.
• W2999971237 cites W2805789627 @default.
• W2999971237 cites W2807705809 @default.
• W2999971237 cites W2883860912 @default.
• W2999971237 cites W2886791611 @default.

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