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• W2999990507 startingPage "533" @default.
• W2999990507 abstract "Arthritis, including osteoarthritis (OA) and rheumatoid arthritis (RA), is the leading cause of years lived with disability (YLD) worldwide. Although pain is the cardinal symptom of arthritis, which is directly related to function and quality of life, the elucidation of the mechanism underlying the pathogenesis of pain in arthritis has lagged behind other areas, such as inflammation control and regulation of autoimmunity. The lack of therapeutics for optimal pain management is partially responsible for the current epidemic of opioid and narcotic abuse. Recent advances in animal experimentation and molecular biology have led to significant progress in our understanding of arthritis pain. Despite the inherent problems in the extrapolation of data gained from animal pain studies to arthritis in human patients, the critical assessment of molecular mediators and translational studies would help to define the relevance of novel therapeutic targets for the treatment of arthritis pain. This review discusses biological and molecular mechanisms underlying the pathogenesis of arthritis pain determined in animal models of OA and RA, along with the methodologies used." @default.
• W2999990507 created "2020-01-23" @default.
• W2999990507 creator A5005309170 @default.
• W2999990507 creator A5025713633 @default.
• W2999990507 creator A5078775403 @default.
• W2999990507 date "2020-01-14" @default.
• W2999990507 modified "2023-10-18" @default.
• W2999990507 title "Understanding the Molecular Mechanisms Underlying the Pathogenesis of Arthritis Pain Using Animal Models" @default.
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