Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000000401> ?p ?o ?g. }
- W3000000401 endingPage "117279" @default.
- W3000000401 startingPage "117279" @default.
- W3000000401 abstract "Treadmill exercise is a beneficial treatment following childhood stroke. Thus, studies focusing on the neuroprotective mechanism of exercise training during postischemic treatment in children with ischemic stroke are urgently needed. We evaluated the effects of treadmill exercise on autophagy after cerebral ischemia in young rats. Rats (23–25 days old) underwent cerebral ischemia-reperfusion (CI/R) surgery. The experimental animals were divided into 5 groups, and some groups received either treadmill exercise, a rapamycin (RAPA) injection or combination therapy for 3 or 7 days. We performed a series of experimental tests including neurological scoring, hematoxylin-eosin staining (H&E), Nissl staining, triphenyl tetrazolium chloride (TTC) staining, Western blot analysis (WB), immunofluorescence (IF), enzyme-linked immunosorbent assay (ELISA), transmission electron microscopy (TEM) and Terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) fluorescence. The experimental data indicated that treadmill exercise inhibited autophagy in the ischemic penumbra, inhibited high mobility group box 1 (HMGB1) translocation and binding to Beclin1, reduced apoptosis, reduced infarct volumes, and aided in functional recovery. However, RAPA promoted the opposite effects of treadmill exercise. We found that treadmill exercise improves the neurological deficits induced by CI/R by inhibiting autophagy and HMGB1 binding to Beclin1." @default.
- W3000000401 created "2020-01-23" @default.
- W3000000401 creator A5000423827 @default.
- W3000000401 creator A5002287326 @default.
- W3000000401 creator A5027247156 @default.
- W3000000401 creator A5036099494 @default.
- W3000000401 creator A5048145308 @default.
- W3000000401 creator A5052449958 @default.
- W3000000401 creator A5058764008 @default.
- W3000000401 creator A5070005028 @default.
- W3000000401 creator A5079202624 @default.
- W3000000401 creator A5080134626 @default.
- W3000000401 creator A5081515882 @default.
- W3000000401 date "2020-02-01" @default.
- W3000000401 modified "2023-10-06" @default.
- W3000000401 title "Treadmill exercise improves neurological function by inhibiting autophagy and the binding of HMGB1 to Beclin1 in MCAO juvenile rats" @default.
- W3000000401 cites W1523367786 @default.
- W3000000401 cites W1769546429 @default.
- W3000000401 cites W1939400808 @default.
- W3000000401 cites W1972336737 @default.
- W3000000401 cites W1986871890 @default.
- W3000000401 cites W2007012993 @default.
- W3000000401 cites W2009839229 @default.
- W3000000401 cites W2020097343 @default.
- W3000000401 cites W2023080902 @default.
- W3000000401 cites W2030430356 @default.
- W3000000401 cites W2041759782 @default.
- W3000000401 cites W2056142022 @default.
- W3000000401 cites W2109003100 @default.
- W3000000401 cites W2110141704 @default.
- W3000000401 cites W2114242405 @default.
- W3000000401 cites W2129854180 @default.
- W3000000401 cites W2134196875 @default.
- W3000000401 cites W2150138853 @default.
- W3000000401 cites W2163047720 @default.
- W3000000401 cites W2232187600 @default.
- W3000000401 cites W2271539307 @default.
- W3000000401 cites W2500152691 @default.
- W3000000401 cites W2523005194 @default.
- W3000000401 cites W2529899971 @default.
- W3000000401 cites W2561943186 @default.
- W3000000401 cites W2565533470 @default.
- W3000000401 cites W2585435048 @default.
- W3000000401 cites W2590617978 @default.
- W3000000401 cites W2592177823 @default.
- W3000000401 cites W2594524236 @default.
- W3000000401 cites W2611428217 @default.
- W3000000401 cites W2746531389 @default.
- W3000000401 cites W2747892221 @default.
- W3000000401 cites W2767457396 @default.
- W3000000401 cites W2792726946 @default.
- W3000000401 cites W2793077245 @default.
- W3000000401 cites W2891892218 @default.
- W3000000401 cites W2904040737 @default.
- W3000000401 cites W2908861320 @default.
- W3000000401 cites W2909938443 @default.
- W3000000401 cites W2911497402 @default.
- W3000000401 cites W2921629818 @default.
- W3000000401 cites W2922220570 @default.
- W3000000401 cites W2930384432 @default.
- W3000000401 cites W2980793704 @default.
- W3000000401 cites W775311174 @default.
- W3000000401 doi "https://doi.org/10.1016/j.lfs.2020.117279" @default.
- W3000000401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31926245" @default.
- W3000000401 hasPublicationYear "2020" @default.
- W3000000401 type Work @default.
- W3000000401 sameAs 3000000401 @default.
- W3000000401 citedByCount "14" @default.
- W3000000401 countsByYear W30000004012020 @default.
- W3000000401 countsByYear W30000004012021 @default.
- W3000000401 countsByYear W30000004012022 @default.
- W3000000401 countsByYear W30000004012023 @default.
- W3000000401 crossrefType "journal-article" @default.
- W3000000401 hasAuthorship W3000000401A5000423827 @default.
- W3000000401 hasAuthorship W3000000401A5002287326 @default.
- W3000000401 hasAuthorship W3000000401A5027247156 @default.
- W3000000401 hasAuthorship W3000000401A5036099494 @default.
- W3000000401 hasAuthorship W3000000401A5048145308 @default.
- W3000000401 hasAuthorship W3000000401A5052449958 @default.
- W3000000401 hasAuthorship W3000000401A5058764008 @default.
- W3000000401 hasAuthorship W3000000401A5070005028 @default.
- W3000000401 hasAuthorship W3000000401A5079202624 @default.
- W3000000401 hasAuthorship W3000000401A5080134626 @default.
- W3000000401 hasAuthorship W3000000401A5081515882 @default.
- W3000000401 hasConcept C104317684 @default.
- W3000000401 hasConcept C126322002 @default.
- W3000000401 hasConcept C127413603 @default.
- W3000000401 hasConcept C134018914 @default.
- W3000000401 hasConcept C142724271 @default.
- W3000000401 hasConcept C154113507 @default.
- W3000000401 hasConcept C185592680 @default.
- W3000000401 hasConcept C190283241 @default.
- W3000000401 hasConcept C196795494 @default.
- W3000000401 hasConcept C203522944 @default.
- W3000000401 hasConcept C204232928 @default.
- W3000000401 hasConcept C2776390042 @default.
- W3000000401 hasConcept C2776415932 @default.
- W3000000401 hasConcept C2780577055 @default.