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- W3000032353 endingPage "892" @default.
- W3000032353 startingPage "854" @default.
- W3000032353 abstract "Background: Proteins present a modular organization made up of several domains. Apart from the domains playing catalytic functions, many others are crucial to recruit interactors. The latter domains can be defined as PIDs (Protein Interaction Domains) and are responsible for pivotal outcomes in signal transduction and a certain array of normal physiological and disease-related pathways. Targeting such PIDs with small molecules and peptides able to modulate their interaction networks, may represent a valuable route to discover novel therapeutics. Objective: This work represents a continuation of a very recent review describing PIDs able to recognize post-translationally modified peptide segments. On the contrary, the second part concerns with PIDs that interact with simple peptide sequences provided with standard amino acids. Methods: Crucial structural information on different domain subfamilies and their interactomes was gained by a wide search in different online available databases (including the PDB (Protein Data Bank), the Pfam (Protein family), and the SMART (Simple Modular Architecture Research Tool)). Pubmed was also searched to explore the most recent literature related to the topic. Results and Conclusion: PIDs are multifaceted: they have all diverse structural features and can recognize several consensus sequences. PIDs can be linked to different diseases onset and progression, like cancer or viral infections and find applications in the personalized medicine field. Many efforts have been centered on peptide/peptidomimetic inhibitors of PIDs mediated interactions but much more work needs to be conducted to improve drug-likeness and interaction affinities of identified compounds." @default.
- W3000032353 created "2020-01-23" @default.
- W3000032353 creator A5038213943 @default.
- W3000032353 creator A5066912496 @default.
- W3000032353 creator A5082896813 @default.
- W3000032353 date "2021-02-01" @default.
- W3000032353 modified "2023-09-24" @default.
- W3000032353 title "Protein Interaction Domains: Structural Features and Drug Discovery Applications (Part 2)" @default.
- W3000032353 cites W1520359022 @default.
- W3000032353 cites W1522768354 @default.
- W3000032353 cites W1546858236 @default.
- W3000032353 cites W1586032062 @default.
- W3000032353 cites W1594587420 @default.
- W3000032353 cites W1612964469 @default.
- W3000032353 cites W1817698463 @default.
- W3000032353 cites W1877319849 @default.
- W3000032353 cites W1892578325 @default.
- W3000032353 cites W1913862483 @default.
- W3000032353 cites W1939836144 @default.
- W3000032353 cites W1956050402 @default.
- W3000032353 cites W1964538907 @default.
- W3000032353 cites W1965508899 @default.
- W3000032353 cites W1966231010 @default.
- W3000032353 cites W1966951979 @default.
- W3000032353 cites W1967509236 @default.
- W3000032353 cites W1970989906 @default.
- W3000032353 cites W1974160984 @default.
- W3000032353 cites W1976933694 @default.
- W3000032353 cites W1977791313 @default.
- W3000032353 cites W1979602594 @default.
- W3000032353 cites W1980169631 @default.
- W3000032353 cites W1980344333 @default.
- W3000032353 cites W1982186905 @default.
- W3000032353 cites W1983297180 @default.
- W3000032353 cites W1987521895 @default.
- W3000032353 cites W1988319136 @default.
- W3000032353 cites W1989168454 @default.
- W3000032353 cites W1990012947 @default.
- W3000032353 cites W1990472107 @default.
- W3000032353 cites W1990988819 @default.
- W3000032353 cites W1992329048 @default.
- W3000032353 cites W1993029728 @default.
- W3000032353 cites W1994131040 @default.
- W3000032353 cites W1995502625 @default.
- W3000032353 cites W1995793615 @default.
- W3000032353 cites W1999000807 @default.
- W3000032353 cites W2001207288 @default.
- W3000032353 cites W2003929435 @default.
- W3000032353 cites W2006786639 @default.
- W3000032353 cites W2008060990 @default.
- W3000032353 cites W2008577391 @default.
- W3000032353 cites W2011135007 @default.
- W3000032353 cites W2014235532 @default.
- W3000032353 cites W2014390733 @default.
- W3000032353 cites W2015961921 @default.
- W3000032353 cites W2018581402 @default.
- W3000032353 cites W2018837494 @default.
- W3000032353 cites W2019873695 @default.
- W3000032353 cites W2022682918 @default.
- W3000032353 cites W2022840517 @default.
- W3000032353 cites W2023058770 @default.
- W3000032353 cites W2032869387 @default.
- W3000032353 cites W2035285488 @default.
- W3000032353 cites W2036183783 @default.
- W3000032353 cites W2039575075 @default.
- W3000032353 cites W2042651745 @default.
- W3000032353 cites W2043937578 @default.
- W3000032353 cites W2045368008 @default.
- W3000032353 cites W2047307993 @default.
- W3000032353 cites W2048943885 @default.
- W3000032353 cites W2049520420 @default.
- W3000032353 cites W2052215225 @default.
- W3000032353 cites W2052323707 @default.
- W3000032353 cites W2052489882 @default.
- W3000032353 cites W2054595223 @default.
- W3000032353 cites W2055874752 @default.
- W3000032353 cites W2056447843 @default.
- W3000032353 cites W2056775476 @default.
- W3000032353 cites W2057118173 @default.
- W3000032353 cites W2059023146 @default.
- W3000032353 cites W2059434228 @default.
- W3000032353 cites W2060412271 @default.
- W3000032353 cites W2065447689 @default.
- W3000032353 cites W2067654212 @default.
- W3000032353 cites W2067768767 @default.
- W3000032353 cites W2068829311 @default.
- W3000032353 cites W2069107332 @default.
- W3000032353 cites W2071085877 @default.
- W3000032353 cites W2073306537 @default.
- W3000032353 cites W2075622623 @default.
- W3000032353 cites W2076242481 @default.
- W3000032353 cites W2076601226 @default.
- W3000032353 cites W2078591378 @default.
- W3000032353 cites W2080753932 @default.
- W3000032353 cites W2085316245 @default.
- W3000032353 cites W2086868097 @default.
- W3000032353 cites W2088033548 @default.
- W3000032353 cites W2088239473 @default.