Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000050177> ?p ?o ?g. }
- W3000050177 abstract "Negative checkpoint regulators (NCRs) temper the T cell immune response to self-antigens and limit the development of autoimmunity. Unlike all other NCRs that are expressed on activated T lymphocytes, V-type immunoglobulin domain-containing suppressor of T cell activation (VISTA) is expressed on naïve T cells. We report an unexpected heterogeneity within the naïve T cell compartment in mice, where loss of VISTA disrupted the major quiescent naïve T cell subset and enhanced self-reactivity. Agonistic VISTA engagement increased T cell tolerance by promoting antigen-induced peripheral T cell deletion. Although a critical player in naïve T cell homeostasis, the ability of VISTA to restrain naïve T cell responses was lost under inflammatory conditions. VISTA is therefore a distinctive NCR of naïve T cells that is critical for steady-state maintenance of quiescence and peripheral tolerance." @default.
- W3000050177 created "2020-01-23" @default.
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- W3000050177 date "2020-01-17" @default.
- W3000050177 modified "2023-10-10" @default.
- W3000050177 title "VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance" @default.
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