Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000054749> ?p ?o ?g. }
- W3000054749 abstract "Abstract Speciation is associated with substantial rewiring of the regulatory circuitry underlying the expression of genes. Determining which changes are relevant and underlie the emergence of the human brain or its unique susceptibility to neural disease has been challenging. Here we annotate changes to gene regulatory elements (GREs) at cell type resolution in the brains of multiple primate species spanning most of primate evolution. We identify a unique set of regulatory elements that emerged in hominins prior to the separation of humans and chimpanzees. We demonstrate that these hominin gains perferentially affect oligodendrocyte function postnatally and are preferentially affected in the brains of autism patients. This preference is also observed for human-specific GREs suggesting this system is under continued selective pressure. Our data provide a roadmap of regulatory rewiring across primate evolution providing insight into the genomic changes that underlie the emergence of the brain and its susceptibility to neural disease." @default.
- W3000054749 created "2020-01-23" @default.
- W3000054749 creator A5011242278 @default.
- W3000054749 creator A5032247516 @default.
- W3000054749 creator A5032345088 @default.
- W3000054749 creator A5036760028 @default.
- W3000054749 creator A5045991627 @default.
- W3000054749 creator A5057615788 @default.
- W3000054749 creator A5072347898 @default.
- W3000054749 creator A5073981911 @default.
- W3000054749 creator A5074927129 @default.
- W3000054749 creator A5084856558 @default.
- W3000054749 creator A5085896954 @default.
- W3000054749 creator A5087962472 @default.
- W3000054749 date "2020-01-16" @default.
- W3000054749 modified "2023-10-18" @default.
- W3000054749 title "Hominin-specific regulatory elements selectively emerged in oligodendrocytes and are disrupted in autism patients" @default.
- W3000054749 cites W1531821806 @default.
- W3000054749 cites W1625129845 @default.
- W3000054749 cites W1977497843 @default.
- W3000054749 cites W1981301360 @default.
- W3000054749 cites W1983275320 @default.
- W3000054749 cites W1986586739 @default.
- W3000054749 cites W1986803878 @default.
- W3000054749 cites W1988365689 @default.
- W3000054749 cites W1992657248 @default.
- W3000054749 cites W2008627757 @default.
- W3000054749 cites W2022682055 @default.
- W3000054749 cites W2035849784 @default.
- W3000054749 cites W2042396829 @default.
- W3000054749 cites W2053433605 @default.
- W3000054749 cites W2060316084 @default.
- W3000054749 cites W2065418093 @default.
- W3000054749 cites W2068943457 @default.
- W3000054749 cites W2072679946 @default.
- W3000054749 cites W2077596732 @default.
- W3000054749 cites W2079246150 @default.
- W3000054749 cites W2087923797 @default.
- W3000054749 cites W2089806726 @default.
- W3000054749 cites W2095903180 @default.
- W3000054749 cites W2110052715 @default.
- W3000054749 cites W2115779804 @default.
- W3000054749 cites W2120143765 @default.
- W3000054749 cites W2124170577 @default.
- W3000054749 cites W2124514674 @default.
- W3000054749 cites W2125086068 @default.
- W3000054749 cites W2131073955 @default.
- W3000054749 cites W2133938268 @default.
- W3000054749 cites W2144820135 @default.
- W3000054749 cites W2148641246 @default.
- W3000054749 cites W2166656425 @default.
- W3000054749 cites W2256694280 @default.
- W3000054749 cites W2259938310 @default.
- W3000054749 cites W2404695164 @default.
- W3000054749 cites W2511994320 @default.
- W3000054749 cites W2520025142 @default.
- W3000054749 cites W2520453992 @default.
- W3000054749 cites W2522953732 @default.
- W3000054749 cites W2534005127 @default.
- W3000054749 cites W2549513265 @default.
- W3000054749 cites W2560760305 @default.
- W3000054749 cites W2561111713 @default.
- W3000054749 cites W2581719304 @default.
- W3000054749 cites W2588398212 @default.
- W3000054749 cites W2619332462 @default.
- W3000054749 cites W2735004254 @default.
- W3000054749 cites W2745116209 @default.
- W3000054749 cites W2750416916 @default.
- W3000054749 cites W2767142230 @default.
- W3000054749 cites W2803750243 @default.
- W3000054749 cites W2810754857 @default.
- W3000054749 cites W2883810206 @default.
- W3000054749 cites W2893683475 @default.
- W3000054749 cites W2896025743 @default.
- W3000054749 cites W2903689387 @default.
- W3000054749 cites W2904647285 @default.
- W3000054749 cites W2904763455 @default.
- W3000054749 cites W2911725378 @default.
- W3000054749 cites W2914482125 @default.
- W3000054749 cites W2946016273 @default.
- W3000054749 cites W2952602120 @default.
- W3000054749 cites W2969167159 @default.
- W3000054749 cites W3105510776 @default.
- W3000054749 doi "https://doi.org/10.1038/s41467-019-14269-w" @default.
- W3000054749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6965079" @default.
- W3000054749 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31949148" @default.
- W3000054749 hasPublicationYear "2020" @default.
- W3000054749 type Work @default.
- W3000054749 sameAs 3000054749 @default.
- W3000054749 citedByCount "35" @default.
- W3000054749 countsByYear W30000547492018 @default.
- W3000054749 countsByYear W30000547492020 @default.
- W3000054749 countsByYear W30000547492021 @default.
- W3000054749 countsByYear W30000547492022 @default.
- W3000054749 countsByYear W30000547492023 @default.
- W3000054749 crossrefType "journal-article" @default.
- W3000054749 hasAuthorship W3000054749A5011242278 @default.
- W3000054749 hasAuthorship W3000054749A5032247516 @default.
- W3000054749 hasAuthorship W3000054749A5032345088 @default.
- W3000054749 hasAuthorship W3000054749A5036760028 @default.