FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000055552> ?p ?o ?g. }

• W3000055552 abstract "Abstract Background Clopidogrel is an inactive prodrug, it catalyzed into its active form by Cytochrome 450 and Paraoxonase-1(PON-1). polymorphisms of genes encoding these enzymes will affect the efficacy of Clopidogrel. The main objective of our study was to investigate the association of CYP2C19*2, CYP2C19*3 and PON-1Q192R polymorphisms with Clopidogrel resistance and major adverse cardiac events in Jin Hua district in the middle of Zhe Jiang Province in China. Methods One hundred sixty coronary heart disease patients with percutaneous coronary intervention, who were followed-up for 1 year, were enrolled in our study. These patients were co-administered aspirin 100 mg/d and clopidogrel 75 mg/d following a loading dose of 300 mg. The ADP-induced platelet aggregation rate was measured by Platelet aggregator. Genotypes of CYP2C19*2, CYP2C19*3, PON-1Q192R were determined using Sanger sequencing in all patients. Various clinical data were collected. Results The frequencies of CYP2C19*2, CYP2C19*3 and PON-1Q192R homozygous mutant genotypes were significantly lower in non-responders than those in responders. After for all variables, CYP2C19*2, CYP2C19*3 and PON-1Q192R independently increased the risk of clopidogrel resistance with adjusted ORs 46.65(95% CI,1.77–25.04; p = 0.005); 22.74(95% CI, 3.11–166.27; p = 0.002); 5.69 (95% CI,1.06–30.47; p = 0.042). Over a follow-up of 12 months, the incidence of major adverse cardiac events (MACE) in CYP2C19*1/*2, *1/*3, *2/*2, *2/*3 was significantly higher than no mutant genotype (18/40vs.2/63,3/9vs.2/63, 11/6vs.2/63, 7/1vs2/63, respectively). There was no significant correlation between PON-1Q192R mutant allele and MACE. Conclusion Our study was first time to report on CYP2C19 and PON-1 polymorphisms in Jin Hua population in the middle of Zhe Jiang province in China. The carriage of CYP2C19*2 or *3 mutant allele significantly reduced the platelet response to clopidogrel and increase the MACE. The carriage of PON-1 mutant allele also significantly reduced the platelet response to clopidogrel, but would not increase the major adverse cardiac events after 1 year follow-up. Trial registration ChiCTR, ChiCTR1800018316. Registered 11 September 2018 – prospective registered, http://www.chictr.org.cn/edit.aspx?pid=30927&htm=4 ." @default.
• W3000055552 created "2020-01-23" @default.
• W3000055552 creator A5000045667 @default.
• W3000055552 creator A5028710085 @default.
• W3000055552 creator A5041212598 @default.
• W3000055552 creator A5043356374 @default.
• W3000055552 date "2020-01-03" @default.
• W3000055552 modified "2023-10-06" @default.
• W3000055552 title "The impact of cytochrome 450 and Paraoxonase polymorphisms on clopidogrel resistance and major adverse cardiac events in coronary heart disease patients after percutaneous coronary intervention" @default.
• W3000055552 cites W1590243361 @default.
• W3000055552 cites W1607291215 @default.
• W3000055552 cites W1971632869 @default.
• W3000055552 cites W1978212707 @default.
• W3000055552 cites W1987761929 @default.
• W3000055552 cites W2012064856 @default.
• W3000055552 cites W2021241943 @default.
• W3000055552 cites W2029179690 @default.
• W3000055552 cites W2038415746 @default.
• W3000055552 cites W2039454408 @default.
• W3000055552 cites W2042413076 @default.
• W3000055552 cites W2057193583 @default.
• W3000055552 cites W2078713210 @default.
• W3000055552 cites W2085190889 @default.
• W3000055552 cites W2113787373 @default.
• W3000055552 cites W2122844568 @default.
• W3000055552 cites W2125943244 @default.
• W3000055552 cites W2135575592 @default.
• W3000055552 cites W2154940301 @default.
• W3000055552 cites W2163032294 @default.
• W3000055552 cites W2163136018 @default.
• W3000055552 cites W2571139424 @default.
• W3000055552 cites W2584285506 @default.
• W3000055552 cites W2611480624 @default.
• W3000055552 cites W2736946910 @default.
• W3000055552 cites W2762916919 @default.
• W3000055552 cites W2774265477 @default.
• W3000055552 cites W2783458104 @default.
• W3000055552 cites W2791350316 @default.
• W3000055552 cites W2885923307 @default.
• W3000055552 cites W2923506712 @default.
• W3000055552 cites W2945924635 @default.
• W3000055552 cites W2947476427 @default.
• W3000055552 cites W2954135047 @default.
• W3000055552 cites W2963741369 @default.
• W3000055552 cites W2965473879 @default.
• W3000055552 cites W834634271 @default.
• W3000055552 doi "https://doi.org/10.1186/s40360-019-0378-7" @default.
• W3000055552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6942367" @default.
• W3000055552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31900240" @default.
• W3000055552 hasPublicationYear "2020" @default.
• W3000055552 type Work @default.
• W3000055552 sameAs 3000055552 @default.
• W3000055552 citedByCount "15" @default.
• W3000055552 countsByYear W30000555522020 @default.
• W3000055552 countsByYear W30000555522021 @default.
• W3000055552 countsByYear W30000555522022 @default.
• W3000055552 countsByYear W30000555522023 @default.
• W3000055552 crossrefType "journal-article" @default.
• W3000055552 hasAuthorship W3000055552A5000045667 @default.
• W3000055552 hasAuthorship W3000055552A5028710085 @default.
• W3000055552 hasAuthorship W3000055552A5041212598 @default.
• W3000055552 hasAuthorship W3000055552A5043356374 @default.
• W3000055552 hasBestOaLocation W30000555521 @default.
• W3000055552 hasConcept C126322002 @default.
• W3000055552 hasConcept C140840227 @default.
• W3000055552 hasConcept C164705383 @default.
• W3000055552 hasConcept C2777628954 @default.
• W3000055552 hasConcept C2777849778 @default.
• W3000055552 hasConcept C2780400711 @default.
• W3000055552 hasConcept C2780739214 @default.
• W3000055552 hasConcept C500558357 @default.
• W3000055552 hasConcept C526171541 @default.
• W3000055552 hasConcept C62231903 @default.
• W3000055552 hasConcept C71924100 @default.
• W3000055552 hasConcept C90924648 @default.
• W3000055552 hasConcept C98274493 @default.
• W3000055552 hasConceptScore W3000055552C126322002 @default.
• W3000055552 hasConceptScore W3000055552C140840227 @default.
• W3000055552 hasConceptScore W3000055552C164705383 @default.
• W3000055552 hasConceptScore W3000055552C2777628954 @default.
• W3000055552 hasConceptScore W3000055552C2777849778 @default.
• W3000055552 hasConceptScore W3000055552C2780400711 @default.
• W3000055552 hasConceptScore W3000055552C2780739214 @default.
• W3000055552 hasConceptScore W3000055552C500558357 @default.
• W3000055552 hasConceptScore W3000055552C526171541 @default.
• W3000055552 hasConceptScore W3000055552C62231903 @default.
• W3000055552 hasConceptScore W3000055552C71924100 @default.
• W3000055552 hasConceptScore W3000055552C90924648 @default.
• W3000055552 hasConceptScore W3000055552C98274493 @default.
• W3000055552 hasIssue "1" @default.
• W3000055552 hasLocation W30000555521 @default.
• W3000055552 hasLocation W30000555522 @default.
• W3000055552 hasLocation W30000555523 @default.
• W3000055552 hasLocation W30000555524 @default.
• W3000055552 hasOpenAccess W3000055552 @default.
• W3000055552 hasPrimaryLocation W30000555521 @default.
• W3000055552 hasRelatedWork W2134433002 @default.
• W3000055552 hasRelatedWork W2553125603 @default.
• W3000055552 hasRelatedWork W2736946910 @default.
• W3000055552 hasRelatedWork W2791927681 @default.

• next