Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000066369> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3000066369 abstract "Abstract Aging is associated with the progressive decay of cognitive function. Hippocampus-dependent processes, such as the formation of spatial memory, are particularly vulnerable to aging. Currently, the molecular mechanisms responsible for age-dependent cognitive decline are largely unknown. Here, we investigated the expression and function of the growth arrest DNA damage gamma (Gadd45γ) during aging and cognition. We report that Gadd45γ expression is increased in the hippocampus of aged humans and that Gadd45γ overexpression in the young adult mouse hippocampus compromises cognition. Moreover, Gadd45γ overexpression in hippocampal neurons disrupted CREB signaling and the expression of well-established activity-regulated genes. This work shows that Gadd45γ expression is tightly controlled in the hippocampus and its disruption may be a mechanism contributing to age-related cognitive impairments observed in humans." @default.
- W3000066369 created "2020-01-23" @default.
- W3000066369 creator A5006720958 @default.
- W3000066369 creator A5038158794 @default.
- W3000066369 creator A5047090081 @default.
- W3000066369 creator A5066245546 @default.
- W3000066369 creator A5067187887 @default.
- W3000066369 creator A5068245914 @default.
- W3000066369 creator A5072439256 @default.
- W3000066369 creator A5084099644 @default.
- W3000066369 date "2020-01-14" @default.
- W3000066369 modified "2023-09-27" @default.
- W3000066369 title "Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice" @default.
- W3000066369 cites W1980303046 @default.
- W3000066369 cites W1985806334 @default.
- W3000066369 cites W1992842030 @default.
- W3000066369 cites W2016461803 @default.
- W3000066369 cites W2022689242 @default.
- W3000066369 cites W2039296833 @default.
- W3000066369 cites W2039397120 @default.
- W3000066369 cites W2057849136 @default.
- W3000066369 cites W2057956870 @default.
- W3000066369 cites W2069049877 @default.
- W3000066369 cites W2073351138 @default.
- W3000066369 cites W2103813752 @default.
- W3000066369 cites W2104010831 @default.
- W3000066369 cites W2106986486 @default.
- W3000066369 cites W2113005513 @default.
- W3000066369 cites W2133947651 @default.
- W3000066369 cites W2167279371 @default.
- W3000066369 cites W2168922851 @default.
- W3000066369 cites W2180741876 @default.
- W3000066369 cites W2262614321 @default.
- W3000066369 cites W2344805654 @default.
- W3000066369 cites W2771522079 @default.
- W3000066369 cites W2786912169 @default.
- W3000066369 cites W2793988709 @default.
- W3000066369 cites W2811459126 @default.
- W3000066369 cites W2887564423 @default.
- W3000066369 cites W2904054431 @default.
- W3000066369 cites W2944850463 @default.
- W3000066369 cites W2996495672 @default.
- W3000066369 cites W3003892910 @default.
- W3000066369 cites W4251259027 @default.
- W3000066369 doi "https://doi.org/10.1101/2020.01.12.903112" @default.
- W3000066369 hasPublicationYear "2020" @default.
- W3000066369 type Work @default.
- W3000066369 sameAs 3000066369 @default.
- W3000066369 citedByCount "0" @default.
- W3000066369 crossrefType "posted-content" @default.
- W3000066369 hasAuthorship W3000066369A5006720958 @default.
- W3000066369 hasAuthorship W3000066369A5038158794 @default.
- W3000066369 hasAuthorship W3000066369A5047090081 @default.
- W3000066369 hasAuthorship W3000066369A5066245546 @default.
- W3000066369 hasAuthorship W3000066369A5067187887 @default.
- W3000066369 hasAuthorship W3000066369A5068245914 @default.
- W3000066369 hasAuthorship W3000066369A5072439256 @default.
- W3000066369 hasAuthorship W3000066369A5084099644 @default.
- W3000066369 hasBestOaLocation W30000663691 @default.
- W3000066369 hasConcept C104317684 @default.
- W3000066369 hasConcept C105696609 @default.
- W3000066369 hasConcept C148762608 @default.
- W3000066369 hasConcept C1629964 @default.
- W3000066369 hasConcept C169760540 @default.
- W3000066369 hasConcept C169900460 @default.
- W3000066369 hasConcept C2778021510 @default.
- W3000066369 hasConcept C2781161787 @default.
- W3000066369 hasConcept C29537977 @default.
- W3000066369 hasConcept C54355233 @default.
- W3000066369 hasConcept C86339819 @default.
- W3000066369 hasConcept C86803240 @default.
- W3000066369 hasConceptScore W3000066369C104317684 @default.
- W3000066369 hasConceptScore W3000066369C105696609 @default.
- W3000066369 hasConceptScore W3000066369C148762608 @default.
- W3000066369 hasConceptScore W3000066369C1629964 @default.
- W3000066369 hasConceptScore W3000066369C169760540 @default.
- W3000066369 hasConceptScore W3000066369C169900460 @default.
- W3000066369 hasConceptScore W3000066369C2778021510 @default.
- W3000066369 hasConceptScore W3000066369C2781161787 @default.
- W3000066369 hasConceptScore W3000066369C29537977 @default.
- W3000066369 hasConceptScore W3000066369C54355233 @default.
- W3000066369 hasConceptScore W3000066369C86339819 @default.
- W3000066369 hasConceptScore W3000066369C86803240 @default.
- W3000066369 hasLocation W30000663691 @default.
- W3000066369 hasOpenAccess W3000066369 @default.
- W3000066369 hasPrimaryLocation W30000663691 @default.
- W3000066369 hasRelatedWork W10929422 @default.
- W3000066369 hasRelatedWork W11729134 @default.
- W3000066369 hasRelatedWork W12009188 @default.
- W3000066369 hasRelatedWork W13643686 @default.
- W3000066369 hasRelatedWork W13973986 @default.
- W3000066369 hasRelatedWork W14678202 @default.
- W3000066369 hasRelatedWork W16671885 @default.
- W3000066369 hasRelatedWork W18210457 @default.
- W3000066369 hasRelatedWork W2623691 @default.
- W3000066369 hasRelatedWork W8230954 @default.
- W3000066369 isParatext "false" @default.
- W3000066369 isRetracted "false" @default.
- W3000066369 magId "3000066369" @default.
- W3000066369 workType "article" @default.