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- W3000080966 abstract "Traumatic brain injury (TBI) is a commonly occurring injury in sports, victims of motor vehicle accidents, and falls. TBI has become a pressing public health concern with no specific therapeutic treatment. Mild TBI (mTBI), which accounts for approximately 90% of all TBI cases, may frequently lead to long-lasting cognitive, behavioral, and emotional impairments. The incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are gastrointestinal hormones that induce glucose-dependent insulin secretion, promote β-cell proliferation, and enhance resistance to apoptosis. GLP-1 mimetics are marketed as treatments for type 2 diabetes mellitus (T2DM) and are well tolerated. Both GLP-1 and GIP mimetics have shown neuroprotective properties in animal models of Parkinson's and Alzheimer's disease. The aim of this study is to evaluate the potential neuroprotective effects of liraglutide, a GLP-1 analog, and twincretin, a dual GLP-1R/GIPR agonist, in a murine mTBI model. First, we subjected mice to mTBI using a weight-drop device and, thereafter, administered liraglutide or twincretin as a 7-day regimen of subcutaneous (s.c.) injections. We then investigated the effects of these drugs on mTBI-induced cognitive impairments, neurodegeneration, and neuroinflammation. Finally, we assessed their effects on neuroprotective proteins expression that are downstream to GLP-1R/GIPR activation; specifically, PI3K and PKA phosphorylation. Both drugs ameliorated mTBI-induced cognitive impairments evaluated by the novel object recognition (NOR) and the Y-maze paradigms in which neither anxiety nor locomotor activity were confounds, as the latter were unaffected by either mTBI or drugs. Additionally, both drugs significantly mitigated mTBI-induced neurodegeneration and neuroinflammation, as quantified by immunohistochemical staining with Fluoro-Jade/anti-NeuN and anti-Iba-1 antibodies, respectively. mTBI challenge significantly decreased PKA phosphorylation levels in ipsilateral cortex, which was mitigated by both drugs. However, PI3K phosphorylation was not affected by mTBI. These findings offer a new potential therapeutic approach to treat mTBI, and support further investigation of the neuroprotective effects and mechanism of action of incretin-based therapies for neurological disorders." @default.
- W3000080966 created "2020-01-23" @default.
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- W3000080966 date "2020-01-10" @default.
- W3000080966 modified "2023-10-16" @default.
- W3000080966 title "Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain Injury" @default.
- W3000080966 cites W1155323411 @default.
- W3000080966 cites W1535374793 @default.
- W3000080966 cites W1572490995 @default.
- W3000080966 cites W1582261481 @default.
- W3000080966 cites W1781730610 @default.
- W3000080966 cites W1967164782 @default.
- W3000080966 cites W1967256054 @default.
- W3000080966 cites W1970029942 @default.
- W3000080966 cites W1972075219 @default.
- W3000080966 cites W1975656204 @default.
- W3000080966 cites W1977118330 @default.
- W3000080966 cites W1978418890 @default.
- W3000080966 cites W1979509360 @default.
- W3000080966 cites W1979535675 @default.
- W3000080966 cites W1979743154 @default.
- W3000080966 cites W1981337226 @default.
- W3000080966 cites W1985241513 @default.
- W3000080966 cites W1990306590 @default.
- W3000080966 cites W1992537350 @default.
- W3000080966 cites W1996672768 @default.
- W3000080966 cites W2006568691 @default.
- W3000080966 cites W2008434382 @default.
- W3000080966 cites W2008958086 @default.
- W3000080966 cites W2009382150 @default.
- W3000080966 cites W2023540371 @default.
- W3000080966 cites W2030233437 @default.
- W3000080966 cites W2030270894 @default.
- W3000080966 cites W2043673143 @default.
- W3000080966 cites W2045846363 @default.
- W3000080966 cites W2047080646 @default.
- W3000080966 cites W2052410726 @default.
- W3000080966 cites W2055499860 @default.
- W3000080966 cites W2067003329 @default.
- W3000080966 cites W2067448822 @default.
- W3000080966 cites W2067692269 @default.
- W3000080966 cites W2077922345 @default.
- W3000080966 cites W2078379881 @default.
- W3000080966 cites W2078803734 @default.
- W3000080966 cites W2078927525 @default.
- W3000080966 cites W2080785707 @default.
- W3000080966 cites W2081319561 @default.
- W3000080966 cites W2084948079 @default.
- W3000080966 cites W2089944792 @default.
- W3000080966 cites W2099831292 @default.
- W3000080966 cites W2106339546 @default.
- W3000080966 cites W2107076497 @default.
- W3000080966 cites W2108687552 @default.
- W3000080966 cites W2112292567 @default.
- W3000080966 cites W2123030262 @default.
- W3000080966 cites W2123319002 @default.
- W3000080966 cites W2124852816 @default.
- W3000080966 cites W2132774188 @default.
- W3000080966 cites W2138677261 @default.
- W3000080966 cites W2143044244 @default.
- W3000080966 cites W2144529104 @default.
- W3000080966 cites W2146373526 @default.
- W3000080966 cites W2148456968 @default.
- W3000080966 cites W2149502431 @default.
- W3000080966 cites W2149717292 @default.
- W3000080966 cites W2149800483 @default.
- W3000080966 cites W2151254933 @default.
- W3000080966 cites W2152355721 @default.
- W3000080966 cites W2153005893 @default.
- W3000080966 cites W2164948885 @default.
- W3000080966 cites W2199406275 @default.
- W3000080966 cites W2201435687 @default.
- W3000080966 cites W2206575616 @default.
- W3000080966 cites W2254593697 @default.
- W3000080966 cites W2342553225 @default.
- W3000080966 cites W2370951863 @default.
- W3000080966 cites W2399549279 @default.
- W3000080966 cites W2399979245 @default.
- W3000080966 cites W2411459535 @default.
- W3000080966 cites W2505024819 @default.
- W3000080966 cites W2554906677 @default.
- W3000080966 cites W2558021507 @default.
- W3000080966 cites W2572710398 @default.
- W3000080966 cites W2591971201 @default.
- W3000080966 cites W2599792256 @default.
- W3000080966 cites W2601336399 @default.
- W3000080966 cites W2606627358 @default.
- W3000080966 cites W2609107212 @default.
- W3000080966 cites W2728605505 @default.
- W3000080966 cites W2729977291 @default.