Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000086270> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3000086270 endingPage "358" @default.
- W3000086270 startingPage "353" @default.
- W3000086270 abstract "A class of substituted quinolines (PQs) acts as a gap junction enhancer with the ability to increase the gap junctional intercellular communication in breast cancer cells. This study examined the effect of a combinational treatment of PQs and the antineoplastic drug paclitaxel in a xenograft animal model. Mice were implanted with estradiol-17ß (1.7 mg/pellet) before the injection of 1 × 10 7 T47D breast cancer cells subcutaneously into the inguinal region of mammary fat pad. Animals were treated intraperitoneally with DMSO (control), paclitaxel (10 mg/kg), PQ (25 mg/kg), or a combinational treatment of paclitaxel and PQ. There was no significant difference between the paclitaxel-treated animals and the control group after seven injections of treatment for 2 weeks. All mice treated with PQ had a significant decrease in mammary tumor growth. The combinational treatment of paclitaxel and PQ1 or PQ7 showed a reduction in tumor growth by 2.3- and 2.2-fold, respectively, compared to paclitaxel alone after seven treatments every 2 days. Molecular analysis indicated a significant increase of gap junction proteins and caspase signaling in PQ and paclitaxel-treated tissues compared to control. Furthermore, there is evidence of an upregulation of Cyclin D1 expression in paclitaxel-treated tumors compared to control, suggesting that the neoplastic cells were highly proliferative and nonresponsive to the paclitaxel alone. We have showed for the first time an increase in the efficacy of antineoplastic drugs via the enhancement of gap junctions with PQs, a specific class of gap junction enhancers." @default.
- W3000086270 created "2020-01-23" @default.
- W3000086270 creator A5039465161 @default.
- W3000086270 creator A5047329480 @default.
- W3000086270 date "2020-04-01" @default.
- W3000086270 modified "2023-09-23" @default.
- W3000086270 title "Combinational treatment of gap junction enhancers and paclitaxel attenuates mammary tumor growth" @default.
- W3000086270 cites W126357909 @default.
- W3000086270 cites W1550247880 @default.
- W3000086270 cites W1973222739 @default.
- W3000086270 cites W1985477492 @default.
- W3000086270 cites W1986688289 @default.
- W3000086270 cites W2012525123 @default.
- W3000086270 cites W2012826978 @default.
- W3000086270 cites W2025128734 @default.
- W3000086270 cites W2075843047 @default.
- W3000086270 cites W2078127187 @default.
- W3000086270 cites W2081326784 @default.
- W3000086270 cites W2082481905 @default.
- W3000086270 cites W2090627913 @default.
- W3000086270 cites W2099041122 @default.
- W3000086270 cites W2140656629 @default.
- W3000086270 cites W2146777040 @default.
- W3000086270 cites W2314200711 @default.
- W3000086270 cites W2781525129 @default.
- W3000086270 doi "https://doi.org/10.1097/cad.0000000000000879" @default.
- W3000086270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31913199" @default.
- W3000086270 hasPublicationYear "2020" @default.
- W3000086270 type Work @default.
- W3000086270 sameAs 3000086270 @default.
- W3000086270 citedByCount "1" @default.
- W3000086270 countsByYear W30000862702022 @default.
- W3000086270 crossrefType "journal-article" @default.
- W3000086270 hasAuthorship W3000086270A5039465161 @default.
- W3000086270 hasAuthorship W3000086270A5047329480 @default.
- W3000086270 hasConcept C104317684 @default.
- W3000086270 hasConcept C126322002 @default.
- W3000086270 hasConcept C127561419 @default.
- W3000086270 hasConcept C158157758 @default.
- W3000086270 hasConcept C185592680 @default.
- W3000086270 hasConcept C2776694085 @default.
- W3000086270 hasConcept C2777292972 @default.
- W3000086270 hasConcept C502942594 @default.
- W3000086270 hasConcept C55493867 @default.
- W3000086270 hasConcept C71924100 @default.
- W3000086270 hasConcept C79879829 @default.
- W3000086270 hasConcept C98274493 @default.
- W3000086270 hasConceptScore W3000086270C104317684 @default.
- W3000086270 hasConceptScore W3000086270C126322002 @default.
- W3000086270 hasConceptScore W3000086270C127561419 @default.
- W3000086270 hasConceptScore W3000086270C158157758 @default.
- W3000086270 hasConceptScore W3000086270C185592680 @default.
- W3000086270 hasConceptScore W3000086270C2776694085 @default.
- W3000086270 hasConceptScore W3000086270C2777292972 @default.
- W3000086270 hasConceptScore W3000086270C502942594 @default.
- W3000086270 hasConceptScore W3000086270C55493867 @default.
- W3000086270 hasConceptScore W3000086270C71924100 @default.
- W3000086270 hasConceptScore W3000086270C79879829 @default.
- W3000086270 hasConceptScore W3000086270C98274493 @default.
- W3000086270 hasIssue "4" @default.
- W3000086270 hasLocation W30000862701 @default.
- W3000086270 hasOpenAccess W3000086270 @default.
- W3000086270 hasPrimaryLocation W30000862701 @default.
- W3000086270 hasRelatedWork W1996171153 @default.
- W3000086270 hasRelatedWork W1996833338 @default.
- W3000086270 hasRelatedWork W2045698890 @default.
- W3000086270 hasRelatedWork W2748952813 @default.
- W3000086270 hasRelatedWork W2772289803 @default.
- W3000086270 hasRelatedWork W2899084033 @default.
- W3000086270 hasRelatedWork W3092618728 @default.
- W3000086270 hasRelatedWork W3175097207 @default.
- W3000086270 hasRelatedWork W4200240292 @default.
- W3000086270 hasRelatedWork W4286542840 @default.
- W3000086270 hasVolume "31" @default.
- W3000086270 isParatext "false" @default.
- W3000086270 isRetracted "false" @default.
- W3000086270 magId "3000086270" @default.
- W3000086270 workType "article" @default.