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- W3000087842 endingPage "113181" @default.
- W3000087842 startingPage "113181" @default.
- W3000087842 abstract "The human brain consumes more energy than any other organ in the body and it relies on an uninterrupted supply of energy in the form of adenosine triphosphate (ATP) to maintain normal cognitive function. This constant supply of energy is made available through an interdependent system of metabolic pathways in neurons, glia and endothelial cells that each have specialized roles in the delivery and metabolism of multiple energetic substrates. Perturbations in brain energy metabolism is associated with a number of different neurodegenerative conditions including impairments in cognition associated with infection by the Human Immunodeficiency Type 1 Virus (HIV-1). Adaptive changes in brain energy metabolism are apparent early following infection, do not fully normalize with the initiation of antiretroviral therapy (ART), and often worsen with length of infection and duration of anti-retroviral therapeutic use. There is now a considerable amount of cumulative evidence that suggests mild forms of cognitive impairments in people living with HIV-1 (PLWH) may be reversible and are associated with specific modifications in brain energy metabolism. In this review we discuss brain energy metabolism with an emphasis on adaptations that occur in response to HIV-1 infection. The potential for interventions that target brain energy metabolism to preserve or restore cognition in PLWH are also discussed." @default.
- W3000087842 created "2020-01-23" @default.
- W3000087842 creator A5018795768 @default.
- W3000087842 creator A5022491794 @default.
- W3000087842 creator A5023686004 @default.
- W3000087842 creator A5039901508 @default.
- W3000087842 creator A5074631924 @default.
- W3000087842 creator A5078466007 @default.
- W3000087842 creator A5085674779 @default.
- W3000087842 date "2020-05-01" @default.
- W3000087842 modified "2023-10-17" @default.
- W3000087842 title "Bioenergetic adaptations to HIV infection. Could modulation of energy substrate utilization improve brain health in people living with HIV-1?" @default.
- W3000087842 cites W1497884244 @default.
- W3000087842 cites W1502620001 @default.
- W3000087842 cites W1507370673 @default.
- W3000087842 cites W1527910050 @default.
- W3000087842 cites W1529577194 @default.
- W3000087842 cites W1544076335 @default.
- W3000087842 cites W1553529648 @default.
- W3000087842 cites W1559185749 @default.
- W3000087842 cites W1582502012 @default.
- W3000087842 cites W1594199569 @default.
- W3000087842 cites W1643525023 @default.
- W3000087842 cites W1673751863 @default.
- W3000087842 cites W1794396397 @default.
- W3000087842 cites W1797578063 @default.
- W3000087842 cites W18243548 @default.
- W3000087842 cites W184718354 @default.
- W3000087842 cites W1900609545 @default.
- W3000087842 cites W1906511061 @default.
- W3000087842 cites W1928529925 @default.
- W3000087842 cites W1930009458 @default.
- W3000087842 cites W1938553409 @default.
- W3000087842 cites W1953529450 @default.
- W3000087842 cites W1958525759 @default.
- W3000087842 cites W1964964168 @default.
- W3000087842 cites W1968469575 @default.
- W3000087842 cites W1970325459 @default.
- W3000087842 cites W1970779072 @default.
- W3000087842 cites W1971104650 @default.
- W3000087842 cites W1971243166 @default.
- W3000087842 cites W1974166540 @default.
- W3000087842 cites W1974191118 @default.
- W3000087842 cites W1975000729 @default.
- W3000087842 cites W1975250375 @default.
- W3000087842 cites W1976143339 @default.
- W3000087842 cites W1977757546 @default.
- W3000087842 cites W1978049342 @default.
- W3000087842 cites W1979031928 @default.
- W3000087842 cites W1979637734 @default.
- W3000087842 cites W1980885958 @default.
- W3000087842 cites W1981101710 @default.
- W3000087842 cites W1981522372 @default.
- W3000087842 cites W1982433894 @default.
- W3000087842 cites W1982626336 @default.
- W3000087842 cites W1983146430 @default.
- W3000087842 cites W1983185734 @default.
- W3000087842 cites W1983542979 @default.
- W3000087842 cites W1984028198 @default.
- W3000087842 cites W1985134135 @default.
- W3000087842 cites W1986245376 @default.
- W3000087842 cites W1987080089 @default.
- W3000087842 cites W1989044916 @default.
- W3000087842 cites W1989571923 @default.
- W3000087842 cites W1991031250 @default.
- W3000087842 cites W1991648436 @default.
- W3000087842 cites W1991880901 @default.
- W3000087842 cites W1992431456 @default.
- W3000087842 cites W1993407843 @default.
- W3000087842 cites W1994015846 @default.
- W3000087842 cites W1995491925 @default.
- W3000087842 cites W1996469555 @default.
- W3000087842 cites W1998526261 @default.
- W3000087842 cites W1998638899 @default.
- W3000087842 cites W1998976350 @default.
- W3000087842 cites W1999775886 @default.
- W3000087842 cites W2001725826 @default.
- W3000087842 cites W2002271354 @default.
- W3000087842 cites W2002597772 @default.
- W3000087842 cites W2003202961 @default.
- W3000087842 cites W2004325493 @default.
- W3000087842 cites W2005580313 @default.
- W3000087842 cites W2005819729 @default.
- W3000087842 cites W2005925597 @default.
- W3000087842 cites W2008152543 @default.
- W3000087842 cites W2008315416 @default.
- W3000087842 cites W2008809238 @default.
- W3000087842 cites W2009487160 @default.
- W3000087842 cites W2012601853 @default.
- W3000087842 cites W2013160851 @default.
- W3000087842 cites W2013637636 @default.
- W3000087842 cites W2014201583 @default.
- W3000087842 cites W2015016479 @default.
- W3000087842 cites W2015227366 @default.
- W3000087842 cites W2015637760 @default.
- W3000087842 cites W2016927879 @default.
- W3000087842 cites W2018029391 @default.
- W3000087842 cites W2018521507 @default.