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• W3000092425 abstract "To investigate the effects of quercetin on the apoptosis of platelets and to analyze the intrinsic mechanism.Firstly, the effects of quecetin on the apoptosis of platelets was detected by flow cytometry. Secondly, Western blot was used to detect the expression of apoptosis-related proteins in the platelets treated with quercetin for 2 and 4 day.By flow cytometry, it was found that the apoptosis of platelets in the quercetin-treated group (2, 4 and 8 μmol/L) was inhibited, the apoptosis rate of platelets in 2, 4 and 8 μmol/L quercetin group was 3.12%±0.32%, 2.89%±0.15% and 2.31%±0.28%, respectively, which were signigicantly lover than that in control group (P＜0.01). With the increase of quecetin concentration, the proportion ratio of platelets significantly decreased in a concentration-dependent manner（r=-0.9985）. Similar results were observed on the 4th day. Western blot showed that the treatment with quercetin (2, 4 and 8 μmol/L) promoted the expression of anti-apoptotic protein BCL-2, inhibited the expression of pro-apoptotic protein BAX, resulting in a significant increase in the ratio of BCL-2/BAX (P＜0.01), thereby inhibiting the apoptosis of platelets. Similar results were observed on the 4th day.Quercetin can inhibit platelet apoptosis by increasing the ratio of apoptosis-related protein BCL-2/BAX in a concentration-dependent manner.槲皮素对血小板凋亡的影响及其机制.探讨槲皮素对储存损伤期间血小板凋亡的影响及其可能的内在机制.通过流式细胞术检测并分析经不同浓度的槲皮素处理2和4 d的血小板的凋亡情况。通过Western blot 方法检测槲皮素处理2和4 d的血小板相关凋亡蛋白表达的变化.2、4和8 μmol/L槲皮素处理血小板d 2时的凋亡率分别为3.12%±0.32%、2.89%±0.15%、2.31%±0.28%，与对照组相比有显著性差异（P＜0.01），且随着槲皮素浓度的增高，血小板的凋亡比率逐渐降低，即槲皮素对其凋亡的抑制有一定的浓度依赖性（r=-0.9985）；d 4时亦观察到了类似的结果。2、4和8 μmol/L槲皮素处理2 d可促进抗凋亡蛋白 BCL-2表达，抑制促凋亡蛋白 BAX表达，导致BCL-2/BAX蛋白的比例显著升高（P＜0.01），进而抑制血小板的凋亡；d 4时亦观察到了类似的结果.槲皮素可通过上调凋亡相关蛋白BCL-2/BAX比例来抑制血小板凋亡，且对血小板凋亡的抑制有一定的浓度依赖性." @default.
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• W3000092425 date "2019-10-01" @default.
• W3000092425 modified "2023-09-26" @default.
• W3000092425 title "[Effect of Quercetin on Apoptosis of Platelets and Its Mechanism]." @default.
• W3000092425 doi "https://doi.org/10.19746/j.cnki.issn.1009-2137.2019.05.039" @default.
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