Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000117961> ?p ?o ?g. }
- W3000117961 endingPage "165665" @default.
- W3000117961 startingPage "165665" @default.
- W3000117961 abstract "The present study designed to investigate the protective effect of curcumin nanoparticles (CUR-NPs) on the cardiotoxicity induced by doxorubicin. Rats were divided into four groups; control, rats treated daily with CUR-NPs (50 mg/kg) for 14 days, rats treated with an acute dose of doxorubicin (20 mg/kg) and rats treated daily with CUR-NPs for 14 days injected with doxorubicin on the 10th day. After electrocardiogram (ECG) recording from rats at different groups, rat decapitation was carried out and the heart of each rat was excised out to measure the oxidative stress parameters; lipid peroxidation (MDA), nitric oxide (NO) and reduced glutathione (GSH) and the activities of Na,K,ATPase and acetylcholinesterase (AchE). In addition, the levels of dopamine (DA), norepinephrine (NE) and serotonin (5-HT) were determined in the cardiac tissues. Lactate dehydrogenase (LDH) activity was measured in the serum. The ECG recordings indicated that daily pretreatment with CUR- NPs has prevented the tachycardia (i.e. increase in heart rate) and ameliorated the changes in ST wave and QRS complex induced by doxorubicin. In addition, CUR-NPs prevented doxorubicin induced significant increase in MDA, NO, DA, AchE and LDH and doxorubicin induced significant decrease in GSH, NE, 5-HT and Na,K,ATPase. According to the present findings, it could be concluded that CUR-NPs have a protective effect against cardiotoxicity induced by doxorubicin. This may shed more light on the importance of CUR-NPs pretreatment before the application of doxorubicin therapy." @default.
- W3000117961 created "2020-01-23" @default.
- W3000117961 creator A5025836350 @default.
- W3000117961 creator A5027814734 @default.
- W3000117961 creator A5038637267 @default.
- W3000117961 creator A5048287324 @default.
- W3000117961 creator A5050638837 @default.
- W3000117961 creator A5068147011 @default.
- W3000117961 creator A5074731857 @default.
- W3000117961 date "2020-05-01" @default.
- W3000117961 modified "2023-10-06" @default.
- W3000117961 title "Protective effect of curcumin nanoparticles against cardiotoxicity induced by doxorubicin in rat" @default.
- W3000117961 cites W1258584912 @default.
- W3000117961 cites W1566255459 @default.
- W3000117961 cites W1879857152 @default.
- W3000117961 cites W1976294480 @default.
- W3000117961 cites W1977691287 @default.
- W3000117961 cites W1982519435 @default.
- W3000117961 cites W1986499908 @default.
- W3000117961 cites W1994193544 @default.
- W3000117961 cites W1996302501 @default.
- W3000117961 cites W2006277516 @default.
- W3000117961 cites W2024199089 @default.
- W3000117961 cites W2029549580 @default.
- W3000117961 cites W2030926513 @default.
- W3000117961 cites W2034113803 @default.
- W3000117961 cites W2038205497 @default.
- W3000117961 cites W2041711472 @default.
- W3000117961 cites W2043742955 @default.
- W3000117961 cites W2046592449 @default.
- W3000117961 cites W2058263096 @default.
- W3000117961 cites W2060835545 @default.
- W3000117961 cites W2080261836 @default.
- W3000117961 cites W2084304742 @default.
- W3000117961 cites W2087923405 @default.
- W3000117961 cites W2088810650 @default.
- W3000117961 cites W2092956702 @default.
- W3000117961 cites W2093914788 @default.
- W3000117961 cites W2096904076 @default.
- W3000117961 cites W2112885253 @default.
- W3000117961 cites W2119544587 @default.
- W3000117961 cites W2140003651 @default.
- W3000117961 cites W2148299304 @default.
- W3000117961 cites W2271453718 @default.
- W3000117961 cites W2586749137 @default.
- W3000117961 cites W2610087038 @default.
- W3000117961 cites W2735746558 @default.
- W3000117961 cites W2741686574 @default.
- W3000117961 cites W2755290410 @default.
- W3000117961 cites W2766261199 @default.
- W3000117961 cites W2782896483 @default.
- W3000117961 cites W2791115421 @default.
- W3000117961 cites W2805283048 @default.
- W3000117961 cites W2884416933 @default.
- W3000117961 cites W2894206802 @default.
- W3000117961 cites W2903500432 @default.
- W3000117961 cites W2947727992 @default.
- W3000117961 doi "https://doi.org/10.1016/j.bbadis.2020.165665" @default.
- W3000117961 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31918005" @default.
- W3000117961 hasPublicationYear "2020" @default.
- W3000117961 type Work @default.
- W3000117961 sameAs 3000117961 @default.
- W3000117961 citedByCount "39" @default.
- W3000117961 countsByYear W30001179612020 @default.
- W3000117961 countsByYear W30001179612021 @default.
- W3000117961 countsByYear W30001179612022 @default.
- W3000117961 countsByYear W30001179612023 @default.
- W3000117961 crossrefType "journal-article" @default.
- W3000117961 hasAuthorship W3000117961A5025836350 @default.
- W3000117961 hasAuthorship W3000117961A5027814734 @default.
- W3000117961 hasAuthorship W3000117961A5038637267 @default.
- W3000117961 hasAuthorship W3000117961A5048287324 @default.
- W3000117961 hasAuthorship W3000117961A5050638837 @default.
- W3000117961 hasAuthorship W3000117961A5068147011 @default.
- W3000117961 hasAuthorship W3000117961A5074731857 @default.
- W3000117961 hasBestOaLocation W30001179611 @default.
- W3000117961 hasConcept C126322002 @default.
- W3000117961 hasConcept C134018914 @default.
- W3000117961 hasConcept C178790620 @default.
- W3000117961 hasConcept C181199279 @default.
- W3000117961 hasConcept C185592680 @default.
- W3000117961 hasConcept C2776151105 @default.
- W3000117961 hasConcept C2776694085 @default.
- W3000117961 hasConcept C2777318727 @default.
- W3000117961 hasConcept C2778233292 @default.
- W3000117961 hasConcept C2778250585 @default.
- W3000117961 hasConcept C2780829032 @default.
- W3000117961 hasConcept C2781303535 @default.
- W3000117961 hasConcept C29730261 @default.
- W3000117961 hasConcept C519581460 @default.
- W3000117961 hasConcept C538909803 @default.
- W3000117961 hasConcept C55493867 @default.
- W3000117961 hasConcept C71924100 @default.
- W3000117961 hasConcept C98274493 @default.
- W3000117961 hasConceptScore W3000117961C126322002 @default.
- W3000117961 hasConceptScore W3000117961C134018914 @default.
- W3000117961 hasConceptScore W3000117961C178790620 @default.
- W3000117961 hasConceptScore W3000117961C181199279 @default.