Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000147314> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W3000147314 abstract "ABSTRACT Background Although dendritic cells (DCs) are potent antigen presenting cells that can generate T cells specific to tumor antigens, efficacy of immunotherapy using DCs is so far limited. To improve the efficacy of this modality, we conducted a clinical trial of DC vaccination in combination with gemcitabine (GEM) and/or S-1 for patients with advanced pancreatic or biliary tract cancer. The advantages of using these drugs are immunomodulatory functions including the inhibition of regulatory T cells (Tregs). OK432, a toll like receptor (TLR) 4 agonist, was employed to enhance activation of DCs both in vitro and in vivo. Methods 31 patients (17 males, 14 females; aged 27-81 years, median 61 years) with advanced pancreatic (24) or biliary tract (7) cancer refractory to standard treatment were treated with DC vaccination in combination with OK432 and GEM and/or S-1 from 2009 to 2011. Autologous DCs were generated from adherent mononuclear cells using standard protocols. Wilms' tumor 1 (WT1) and/or MUC1 peptide-loaded mature DCs were administered intradermally every 2 weeks for 7 times. Induction of vaccine-induced T cell responses was monitored using HLA-tetramer assays. Results The treatment was well tolerated and none of the patients experienced more than grade 3 adverse events during the treatment period. Of 31 patients, 5 patients had partial response (PR), 14 had stable disease (SD), 2 had mixed response and 10 had progressive disease following one course of the treatment. Median overall survival was 289 days for all patients, which was longer than that of the patients treated with GEM and/or S-1.Survival of patients achieving PR or SD (responder) after one course of DC vaccination was longer than those who did not respond to the treatment (p Conclusions DC vaccine-based immunotherapy combined with a TLR agonist and chemotherapy was demonstrated to be safe and more effective in patients with advanced pancreatic or biliary tract cancer compared with chemotherapy alone. Disclosure All authors have declared no conflicts of interest." @default.
- W3000147314 created "2020-01-23" @default.
- W3000147314 creator A5004999383 @default.
- W3000147314 creator A5049803192 @default.
- W3000147314 date "2012-09-01" @default.
- W3000147314 modified "2023-09-29" @default.
- W3000147314 title "Dendritic Cell Vaccination in Combination with OK432, Gemcitabine And/Or S-1 in Patients with Advanced Pancreatic or Biliary Tract Cancer" @default.
- W3000147314 doi "https://doi.org/10.1016/s0923-7534(20)33298-1" @default.
- W3000147314 hasPublicationYear "2012" @default.
- W3000147314 type Work @default.
- W3000147314 sameAs 3000147314 @default.
- W3000147314 citedByCount "0" @default.
- W3000147314 crossrefType "journal-article" @default.
- W3000147314 hasAuthorship W3000147314A5004999383 @default.
- W3000147314 hasAuthorship W3000147314A5049803192 @default.
- W3000147314 hasBestOaLocation W30001473141 @default.
- W3000147314 hasConcept C121608353 @default.
- W3000147314 hasConcept C126322002 @default.
- W3000147314 hasConcept C143998085 @default.
- W3000147314 hasConcept C147483822 @default.
- W3000147314 hasConcept C197934379 @default.
- W3000147314 hasConcept C203014093 @default.
- W3000147314 hasConcept C22070199 @default.
- W3000147314 hasConcept C2776694085 @default.
- W3000147314 hasConcept C2777701055 @default.
- W3000147314 hasConcept C2778170410 @default.
- W3000147314 hasConcept C2778378633 @default.
- W3000147314 hasConcept C2778822529 @default.
- W3000147314 hasConcept C2780210213 @default.
- W3000147314 hasConcept C2780258809 @default.
- W3000147314 hasConcept C71924100 @default.
- W3000147314 hasConcept C8891405 @default.
- W3000147314 hasConceptScore W3000147314C121608353 @default.
- W3000147314 hasConceptScore W3000147314C126322002 @default.
- W3000147314 hasConceptScore W3000147314C143998085 @default.
- W3000147314 hasConceptScore W3000147314C147483822 @default.
- W3000147314 hasConceptScore W3000147314C197934379 @default.
- W3000147314 hasConceptScore W3000147314C203014093 @default.
- W3000147314 hasConceptScore W3000147314C22070199 @default.
- W3000147314 hasConceptScore W3000147314C2776694085 @default.
- W3000147314 hasConceptScore W3000147314C2777701055 @default.
- W3000147314 hasConceptScore W3000147314C2778170410 @default.
- W3000147314 hasConceptScore W3000147314C2778378633 @default.
- W3000147314 hasConceptScore W3000147314C2778822529 @default.
- W3000147314 hasConceptScore W3000147314C2780210213 @default.
- W3000147314 hasConceptScore W3000147314C2780258809 @default.
- W3000147314 hasConceptScore W3000147314C71924100 @default.
- W3000147314 hasConceptScore W3000147314C8891405 @default.
- W3000147314 hasLocation W30001473141 @default.
- W3000147314 hasOpenAccess W3000147314 @default.
- W3000147314 hasPrimaryLocation W30001473141 @default.
- W3000147314 hasRelatedWork W1973207471 @default.
- W3000147314 hasRelatedWork W1978948371 @default.
- W3000147314 hasRelatedWork W1979743813 @default.
- W3000147314 hasRelatedWork W2066875861 @default.
- W3000147314 hasRelatedWork W2068323100 @default.
- W3000147314 hasRelatedWork W2137116922 @default.
- W3000147314 hasRelatedWork W2162592936 @default.
- W3000147314 hasRelatedWork W2220843277 @default.
- W3000147314 hasRelatedWork W2317873860 @default.
- W3000147314 hasRelatedWork W2322455181 @default.
- W3000147314 hasRelatedWork W2332387424 @default.
- W3000147314 hasRelatedWork W2359995573 @default.
- W3000147314 hasRelatedWork W2564761873 @default.
- W3000147314 hasRelatedWork W2782199253 @default.
- W3000147314 hasRelatedWork W3000203134 @default.
- W3000147314 hasRelatedWork W3029773949 @default.
- W3000147314 hasRelatedWork W3031555661 @default.
- W3000147314 hasRelatedWork W3093184135 @default.
- W3000147314 hasRelatedWork W2318533719 @default.
- W3000147314 hasRelatedWork W2330915698 @default.
- W3000147314 isParatext "false" @default.
- W3000147314 isRetracted "false" @default.
- W3000147314 magId "3000147314" @default.
- W3000147314 workType "article" @default.