FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000147490> ?p ?o ?g. }

• W3000147490 endingPage "821" @default.
• W3000147490 startingPage "804" @default.
• W3000147490 abstract "Abstract Dopamine (DA) has been implicated in modulating multiple cognitive control processes, including the robust maintenance of task sets and memoranda in the face of distractors (cognitive stability) and, conversely, the ability to switch task sets or update the contents of working memory when it is advantageous to do so (cognitive flexibility). In humans, the limited specificity of available pharmacological probes has posed a challenge for understanding the mechanisms by which DA, acting on multiple receptor families across the PFC and striatum, differentially influences these cognitive processes. Using a within-subject, placebo-controlled design, we contrasted the impact of two mechanistically distinct DA drugs, tolcapone (an inhibitor of catechol-O-methyltransferase [COMT], a catecholamine inactivator) and bromocriptine (a DA agonist with preferential affinity for the D2 receptor), on the maintenance and switching of task rules. Given previous work demonstrating that drug effects on behavior are dependent on baseline DA tone, participants were stratified according to genetic polymorphisms associated with cortical (COMT Val158Met) and striatal (Taq1A) DA system function. Our results were partially consistent with an inverted-U-shaped relationship between tolcapone and robust rule maintenance (interaction with COMT genotype) and between bromocriptine and cued rule switching (interaction with Taq1A genotype). However, when task instructions were ambiguous, a third relationship emerged to explain drug effects on spontaneous task switching (interaction of COMT genotype and bromocriptine). Together, this pattern of results suggests that the effects of DA drugs vary not only as a function of the DA system component upon which they act but also on subtle differences in task demands and context." @default.
• W3000147490 created "2020-01-23" @default.
• W3000147490 creator A5046805836 @default.
• W3000147490 creator A5052132328 @default.
• W3000147490 creator A5079111563 @default.
• W3000147490 creator A5088453666 @default.
• W3000147490 creator A5091737528 @default.
• W3000147490 creator A5091780065 @default.
• W3000147490 date "2020-05-01" @default.
• W3000147490 modified "2023-10-13" @default.
• W3000147490 title "Effects of Dopaminergic Drugs on Cognitive Control Processes Vary by Genotype" @default.
• W3000147490 cites W1520514652 @default.
• W3000147490 cites W1584047372 @default.
• W3000147490 cites W1759162153 @default.
• W3000147490 cites W1819927624 @default.
• W3000147490 cites W1951724000 @default.
• W3000147490 cites W1966336405 @default.
• W3000147490 cites W1969052084 @default.
• W3000147490 cites W1969635251 @default.
• W3000147490 cites W1975078962 @default.
• W3000147490 cites W1976641408 @default.
• W3000147490 cites W1977293177 @default.
• W3000147490 cites W1978036977 @default.
• W3000147490 cites W1979792701 @default.
• W3000147490 cites W1984277280 @default.
• W3000147490 cites W1986398237 @default.
• W3000147490 cites W1986827321 @default.
• W3000147490 cites W1990955460 @default.
• W3000147490 cites W1991152368 @default.
• W3000147490 cites W1993177597 @default.
• W3000147490 cites W1994357188 @default.
• W3000147490 cites W1997343027 @default.
• W3000147490 cites W2000926076 @default.
• W3000147490 cites W2002132239 @default.
• W3000147490 cites W2003244414 @default.
• W3000147490 cites W2004202209 @default.
• W3000147490 cites W2007928115 @default.
• W3000147490 cites W2010213938 @default.
• W3000147490 cites W2015098351 @default.
• W3000147490 cites W2017576197 @default.
• W3000147490 cites W2017836845 @default.
• W3000147490 cites W2022961682 @default.
• W3000147490 cites W2024511604 @default.
• W3000147490 cites W2025642774 @default.
• W3000147490 cites W2027119123 @default.
• W3000147490 cites W2038593826 @default.
• W3000147490 cites W2041664592 @default.
• W3000147490 cites W2046835548 @default.
• W3000147490 cites W2047992862 @default.
• W3000147490 cites W2048055615 @default.
• W3000147490 cites W2048148249 @default.
• W3000147490 cites W2054515032 @default.
• W3000147490 cites W2056671172 @default.
• W3000147490 cites W2057538015 @default.
• W3000147490 cites W2059669521 @default.
• W3000147490 cites W2064093295 @default.
• W3000147490 cites W2070493747 @default.
• W3000147490 cites W2073452891 @default.
• W3000147490 cites W2076424973 @default.
• W3000147490 cites W2084024459 @default.
• W3000147490 cites W2087532149 @default.
• W3000147490 cites W2087969332 @default.
• W3000147490 cites W2090055848 @default.
• W3000147490 cites W2094134651 @default.
• W3000147490 cites W2100040984 @default.
• W3000147490 cites W2100978582 @default.
• W3000147490 cites W2106163388 @default.
• W3000147490 cites W2106246424 @default.
• W3000147490 cites W2109691697 @default.
• W3000147490 cites W2118770576 @default.
• W3000147490 cites W2119410682 @default.
• W3000147490 cites W2123236884 @default.
• W3000147490 cites W2124540231 @default.
• W3000147490 cites W2127662432 @default.
• W3000147490 cites W2132042075 @default.
• W3000147490 cites W2138419072 @default.
• W3000147490 cites W2138942056 @default.
• W3000147490 cites W2139130137 @default.
• W3000147490 cites W2139146306 @default.
• W3000147490 cites W2141845152 @default.
• W3000147490 cites W2141878312 @default.
• W3000147490 cites W2142946022 @default.
• W3000147490 cites W2145594774 @default.
• W3000147490 cites W2146454742 @default.
• W3000147490 cites W2147623733 @default.
• W3000147490 cites W2151204406 @default.
• W3000147490 cites W2156295541 @default.
• W3000147490 cites W2157066690 @default.
• W3000147490 cites W2164101374 @default.
• W3000147490 cites W2168122820 @default.
• W3000147490 cites W2292952964 @default.
• W3000147490 cites W2325819181 @default.
• W3000147490 cites W2426421998 @default.
• W3000147490 cites W2463085872 @default.
• W3000147490 cites W2468547988 @default.
• W3000147490 cites W2736967024 @default.
• W3000147490 cites W2775004921 @default.
• W3000147490 cites W2792401010 @default.

• next