FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000148385> ?p ?o ?g. }

• W3000148385 endingPage "375" @default.
• W3000148385 startingPage "367" @default.
• W3000148385 abstract "Renal fibrosis leads to end-stage renal disease, but antifibrotic drugs are difficult to develop. Chronic kidney disease often results in muscle wasting, and thereby increases morbidity and mortality. In this work, adeno-associated virus (AAV)-mediated overexpressing miR-29a was hypothesized to counteract renal fibrosis and muscle wasting through muscle–kidney crosstalk in unilateral ureteral obstruction (UUO) mice. miR-29a level was downregulated in the kidney and skeletal muscle of UUO mice. The secretion of exosome-encapsulated miR-29a increased in cultured skeletal muscle satellite cells and HEK293 renal cells after stimulation with serum from UUO mice. This result was confirmed by qPCR and microRNA deep sequencing in the serum exosomes of mice with obstructed ureters. A recombinant AAV-miR-29a was generated to overexpress miR-29a and injected into the tibialis anterior muscle of the mice 2 weeks before UUO surgery. AAV-miR-29a abrogated the UUO-induced upregulation of YY1 and myostatin in skeletal muscles. Renal fibrosis was also partially improved in the UUO mice with intramuscular AAV-miR-29a transduction. AAV-miR-29a overexpression reversed the increase in transforming growth factor β, fibronectin, alpha-smooth muscle actin, and collagen 1A1 and 4A1 levels in the kidney of UUO mice. AAV-green fluorescent protein was applied to trace the AAV route in vivo, and fluorescence was significantly visible in the injected/uninjected muscles and in the kidneys. In conclusion, intramuscular AAV-miR-29a injection attenuates muscle wasting and ameliorates renal fibrosis by downregulating several fibrotic-related proteins in UUO mice." @default.
• W3000148385 created "2020-01-23" @default.
• W3000148385 creator A5001937454 @default.
• W3000148385 creator A5018892762 @default.
• W3000148385 creator A5019647146 @default.
• W3000148385 creator A5036109418 @default.
• W3000148385 creator A5050756000 @default.
• W3000148385 creator A5054938192 @default.
• W3000148385 creator A5063590646 @default.
• W3000148385 creator A5066353889 @default.
• W3000148385 creator A5070644843 @default.
• W3000148385 creator A5086015556 @default.
• W3000148385 creator A5086690723 @default.
• W3000148385 date "2020-03-01" @default.
• W3000148385 modified "2023-10-16" @default.
• W3000148385 title "Exogenous miR-29a Attenuates Muscle Atrophy and Kidney Fibrosis in Unilateral Ureteral Obstruction Mice" @default.
• W3000148385 cites W1531910831 @default.
• W3000148385 cites W1911368542 @default.
• W3000148385 cites W1996584284 @default.
• W3000148385 cites W2000066959 @default.
• W3000148385 cites W2003085654 @default.
• W3000148385 cites W2005185175 @default.
• W3000148385 cites W2016344437 @default.
• W3000148385 cites W2016519161 @default.
• W3000148385 cites W2021917408 @default.
• W3000148385 cites W2028980392 @default.
• W3000148385 cites W2033234733 @default.
• W3000148385 cites W2035938902 @default.
• W3000148385 cites W2037370931 @default.
• W3000148385 cites W2042509721 @default.
• W3000148385 cites W2047071083 @default.
• W3000148385 cites W2058484411 @default.
• W3000148385 cites W2085098316 @default.
• W3000148385 cites W2089186814 @default.
• W3000148385 cites W2091960894 @default.
• W3000148385 cites W2098886779 @default.
• W3000148385 cites W2100560936 @default.
• W3000148385 cites W2108136318 @default.
• W3000148385 cites W2147015347 @default.
• W3000148385 cites W2159753941 @default.
• W3000148385 cites W2159835130 @default.
• W3000148385 cites W2166499121 @default.
• W3000148385 cites W2256903816 @default.
• W3000148385 cites W2308563169 @default.
• W3000148385 cites W2342679639 @default.
• W3000148385 cites W2470343227 @default.
• W3000148385 cites W2550557588 @default.
• W3000148385 cites W2607354563 @default.
• W3000148385 cites W2616389654 @default.
• W3000148385 cites W2620108944 @default.
• W3000148385 cites W2767932648 @default.
• W3000148385 cites W2789194503 @default.
• W3000148385 cites W2911048719 @default.
• W3000148385 cites W2925314732 @default.
• W3000148385 cites W4234281558 @default.
• W3000148385 doi "https://doi.org/10.1089/hum.2019.287" @default.
• W3000148385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7087404" @default.
• W3000148385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31950871" @default.
• W3000148385 hasPublicationYear "2020" @default.
• W3000148385 type Work @default.
• W3000148385 sameAs 3000148385 @default.
• W3000148385 citedByCount "22" @default.
• W3000148385 countsByYear W30001483852020 @default.
• W3000148385 countsByYear W30001483852021 @default.
• W3000148385 countsByYear W30001483852022 @default.
• W3000148385 countsByYear W30001483852023 @default.
• W3000148385 crossrefType "journal-article" @default.
• W3000148385 hasAuthorship W3000148385A5001937454 @default.
• W3000148385 hasAuthorship W3000148385A5018892762 @default.
• W3000148385 hasAuthorship W3000148385A5019647146 @default.
• W3000148385 hasAuthorship W3000148385A5036109418 @default.
• W3000148385 hasAuthorship W3000148385A5050756000 @default.
• W3000148385 hasAuthorship W3000148385A5054938192 @default.
• W3000148385 hasAuthorship W3000148385A5063590646 @default.
• W3000148385 hasAuthorship W3000148385A5066353889 @default.
• W3000148385 hasAuthorship W3000148385A5070644843 @default.
• W3000148385 hasAuthorship W3000148385A5086015556 @default.
• W3000148385 hasAuthorship W3000148385A5086690723 @default.
• W3000148385 hasBestOaLocation W30001483852 @default.
• W3000148385 hasConcept C126322002 @default.
• W3000148385 hasConcept C134018914 @default.
• W3000148385 hasConcept C2776263037 @default.
• W3000148385 hasConcept C2777488582 @default.
• W3000148385 hasConcept C2778653478 @default.
• W3000148385 hasConcept C2779959927 @default.
• W3000148385 hasConcept C2780091579 @default.
• W3000148385 hasConcept C2780559512 @default.
• W3000148385 hasConcept C71924100 @default.
• W3000148385 hasConceptScore W3000148385C126322002 @default.
• W3000148385 hasConceptScore W3000148385C134018914 @default.
• W3000148385 hasConceptScore W3000148385C2776263037 @default.
• W3000148385 hasConceptScore W3000148385C2777488582 @default.
• W3000148385 hasConceptScore W3000148385C2778653478 @default.
• W3000148385 hasConceptScore W3000148385C2779959927 @default.
• W3000148385 hasConceptScore W3000148385C2780091579 @default.
• W3000148385 hasConceptScore W3000148385C2780559512 @default.
• W3000148385 hasConceptScore W3000148385C71924100 @default.
• W3000148385 hasIssue "5-6" @default.

• next