FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000163249> ?p ?o ?g. }

• W3000163249 endingPage "143" @default.
• W3000163249 startingPage "143" @default.
• W3000163249 abstract "In the past two decades, there has been a significant improvement in the understanding of the molecular pathogenesis of Renal Cell Carcinoma (RCC). These insights in the biological pathways have resulted in the development of multiple agents targeting vascular endothelial growth factor (VEGF), as well as inhibitors of the mammalian target of the rapamycin (mTOR) pathway. Most recently, checkpoint inhibitors were shown to have excellent clinical efficacy. Although the patients are living longer, durable complete responses are rarely seen. Historically, high dose interleukin 2 (IL2) therapy has produced durable complete responses in 5% to 8% highly selected patients—albeit with significant toxicity. A durable complete response is a surrogate for a long-term response in the modern era of targeted therapy and checkpoint immunotherapy. Numerous clinical trials are currently exploring the combination of immunotherapy with various targeted therapeutic agents to develop therapies with a higher complete response rate with acceptable toxicity. in this study, we provide a comprehensive review of multiple reported and ongoing clinical trials evaluating the combination of PD-1/PD-L1 inhibitors with either ipilimumab (a cytotoxic T-lymphocyte-associated protein 4, CTLA-4 inhibitor) or with anti-VEGF targeted therapy." @default.
• W3000163249 created "2020-01-23" @default.
• W3000163249 creator A5049546835 @default.
• W3000163249 creator A5050394486 @default.
• W3000163249 creator A5052520933 @default.
• W3000163249 creator A5067071974 @default.
• W3000163249 creator A5083608629 @default.
• W3000163249 date "2020-01-07" @default.
• W3000163249 modified "2023-09-27" @default.
• W3000163249 title "The Future of Immunotherapy-Based Combination Therapy in Metastatic Renal Cell Carcinoma" @default.
• W3000163249 cites W1518184777 @default.
• W3000163249 cites W1577123961 @default.
• W3000163249 cites W2019294726 @default.
• W3000163249 cites W2109154357 @default.
• W3000163249 cites W2123914905 @default.
• W3000163249 cites W2140116071 @default.
• W3000163249 cites W2169435545 @default.
• W3000163249 cites W2186633408 @default.
• W3000163249 cites W2222086386 @default.
• W3000163249 cites W2511951051 @default.
• W3000163249 cites W2590368899 @default.
• W3000163249 cites W2790175716 @default.
• W3000163249 cites W2791442381 @default.
• W3000163249 cites W2792937256 @default.
• W3000163249 cites W2794325180 @default.
• W3000163249 cites W2805302875 @default.
• W3000163249 cites W2891366395 @default.
• W3000163249 cites W2892047081 @default.
• W3000163249 cites W2895870246 @default.
• W3000163249 cites W2895949539 @default.
• W3000163249 cites W2897605435 @default.
• W3000163249 cites W2911188335 @default.
• W3000163249 cites W2911812451 @default.
• W3000163249 cites W2913745075 @default.
• W3000163249 cites W2943887705 @default.
• W3000163249 cites W2947664767 @default.
• W3000163249 cites W2977336705 @default.
• W3000163249 cites W2978477794 @default.
• W3000163249 cites W2978638108 @default.
• W3000163249 cites W2979084159 @default.
• W3000163249 doi "https://doi.org/10.3390/cancers12010143" @default.
• W3000163249 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7017064" @default.
• W3000163249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31936065" @default.
• W3000163249 hasPublicationYear "2020" @default.
• W3000163249 type Work @default.
• W3000163249 sameAs 3000163249 @default.
• W3000163249 citedByCount "36" @default.
• W3000163249 countsByYear W30001632492020 @default.
• W3000163249 countsByYear W30001632492021 @default.
• W3000163249 countsByYear W30001632492022 @default.
• W3000163249 countsByYear W30001632492023 @default.
• W3000163249 crossrefType "journal-article" @default.
• W3000163249 hasAuthorship W3000163249A5049546835 @default.
• W3000163249 hasAuthorship W3000163249A5050394486 @default.
• W3000163249 hasAuthorship W3000163249A5052520933 @default.
• W3000163249 hasAuthorship W3000163249A5067071974 @default.
• W3000163249 hasAuthorship W3000163249A5083608629 @default.
• W3000163249 hasBestOaLocation W30001632491 @default.
• W3000163249 hasConcept C121608353 @default.
• W3000163249 hasConcept C126322002 @default.
• W3000163249 hasConcept C143998085 @default.
• W3000163249 hasConcept C167734588 @default.
• W3000163249 hasConcept C183713625 @default.
• W3000163249 hasConcept C203014093 @default.
• W3000163249 hasConcept C2776820818 @default.
• W3000163249 hasConcept C2776999253 @default.
• W3000163249 hasConcept C2777025900 @default.
• W3000163249 hasConcept C2777472916 @default.
• W3000163249 hasConcept C2777658100 @default.
• W3000163249 hasConcept C2777701055 @default.
• W3000163249 hasConcept C2780030458 @default.
• W3000163249 hasConcept C2781230642 @default.
• W3000163249 hasConcept C2781433595 @default.
• W3000163249 hasConcept C502942594 @default.
• W3000163249 hasConcept C535046627 @default.
• W3000163249 hasConcept C55493867 @default.
• W3000163249 hasConcept C62478195 @default.
• W3000163249 hasConcept C71924100 @default.
• W3000163249 hasConcept C86554907 @default.
• W3000163249 hasConcept C86803240 @default.
• W3000163249 hasConceptScore W3000163249C121608353 @default.
• W3000163249 hasConceptScore W3000163249C126322002 @default.
• W3000163249 hasConceptScore W3000163249C143998085 @default.
• W3000163249 hasConceptScore W3000163249C167734588 @default.
• W3000163249 hasConceptScore W3000163249C183713625 @default.
• W3000163249 hasConceptScore W3000163249C203014093 @default.
• W3000163249 hasConceptScore W3000163249C2776820818 @default.
• W3000163249 hasConceptScore W3000163249C2776999253 @default.
• W3000163249 hasConceptScore W3000163249C2777025900 @default.
• W3000163249 hasConceptScore W3000163249C2777472916 @default.
• W3000163249 hasConceptScore W3000163249C2777658100 @default.
• W3000163249 hasConceptScore W3000163249C2777701055 @default.
• W3000163249 hasConceptScore W3000163249C2780030458 @default.
• W3000163249 hasConceptScore W3000163249C2781230642 @default.
• W3000163249 hasConceptScore W3000163249C2781433595 @default.
• W3000163249 hasConceptScore W3000163249C502942594 @default.
• W3000163249 hasConceptScore W3000163249C535046627 @default.
• W3000163249 hasConceptScore W3000163249C55493867 @default.

• next