Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000167470> ?p ?o ?g. }
- W3000167470 abstract "SUMMARY Inhibitory interneurons integrate into developing circuits in specific ratios and distributions. In the cortex, the formation of inhibitory networks occurs concurrently with the apoptotic elimination of a third of GABAergic interneurons. The molecular mechanisms that select GABAergic interneurons to survive or die are unknown. Here we report that the clustered Protocadherins regulate GABAergic cell survival in the developing brain. Deletion of the Pcdh-gamma genes (Pcdhgs) from GABAergic neurons in mice causes a severe loss of inhibitory neurons in multiple brain regions and results in motor deficits and seizure activities. By focusing on the neocortex and cerebellar cortex, we demonstrate that GABAergic interneuron loss results from elevated apoptosis during the postnatal wave of Bax- dependent programmed cell death. Pro-survival AKT signals are reduced in Pcdhg- deficient interneurons, diminishing the intrinsic capacity of interneurons to compete and incorporate into developing networks. We propose that the Pcdhgs mediate selective GABAergic interneuron survival to contribute to the formation of balanced inhibitory networks." @default.
- W3000167470 created "2020-01-23" @default.
- W3000167470 creator A5003875124 @default.
- W3000167470 creator A5009684074 @default.
- W3000167470 creator A5010183012 @default.
- W3000167470 creator A5023856890 @default.
- W3000167470 creator A5039529778 @default.
- W3000167470 creator A5054476201 @default.
- W3000167470 creator A5063990690 @default.
- W3000167470 creator A5070183392 @default.
- W3000167470 creator A5079310882 @default.
- W3000167470 creator A5080166962 @default.
- W3000167470 creator A5085334412 @default.
- W3000167470 creator A5090017124 @default.
- W3000167470 date "2020-01-15" @default.
- W3000167470 modified "2023-10-18" @default.
- W3000167470 title "The gamma-Protocadherins regulate the survival of GABAergic interneurons during developmentally-regulated cell death" @default.
- W3000167470 cites W1490680688 @default.
- W3000167470 cites W1494436881 @default.
- W3000167470 cites W1827567735 @default.
- W3000167470 cites W1854121368 @default.
- W3000167470 cites W1964322942 @default.
- W3000167470 cites W1964907693 @default.
- W3000167470 cites W1970719523 @default.
- W3000167470 cites W1971749422 @default.
- W3000167470 cites W1981040687 @default.
- W3000167470 cites W1983845889 @default.
- W3000167470 cites W1984940197 @default.
- W3000167470 cites W1987429832 @default.
- W3000167470 cites W1988120710 @default.
- W3000167470 cites W1990545433 @default.
- W3000167470 cites W2008597649 @default.
- W3000167470 cites W2010592389 @default.
- W3000167470 cites W2018210971 @default.
- W3000167470 cites W2019260069 @default.
- W3000167470 cites W2020869819 @default.
- W3000167470 cites W2021519886 @default.
- W3000167470 cites W2023814994 @default.
- W3000167470 cites W2026142886 @default.
- W3000167470 cites W2027713051 @default.
- W3000167470 cites W2028807389 @default.
- W3000167470 cites W2030038054 @default.
- W3000167470 cites W2030204732 @default.
- W3000167470 cites W2033211327 @default.
- W3000167470 cites W2036732136 @default.
- W3000167470 cites W2040574649 @default.
- W3000167470 cites W2042824787 @default.
- W3000167470 cites W2047378045 @default.
- W3000167470 cites W2047936342 @default.
- W3000167470 cites W2052018442 @default.
- W3000167470 cites W2052463507 @default.
- W3000167470 cites W2065011293 @default.
- W3000167470 cites W2065678329 @default.
- W3000167470 cites W2070389026 @default.
- W3000167470 cites W2073248815 @default.
- W3000167470 cites W2081070804 @default.
- W3000167470 cites W2082352870 @default.
- W3000167470 cites W2085162188 @default.
- W3000167470 cites W2085198610 @default.
- W3000167470 cites W2086069938 @default.
- W3000167470 cites W2086200816 @default.
- W3000167470 cites W2088373022 @default.
- W3000167470 cites W2091070768 @default.
- W3000167470 cites W2094844506 @default.
- W3000167470 cites W2096358139 @default.
- W3000167470 cites W2099756187 @default.
- W3000167470 cites W2100826819 @default.
- W3000167470 cites W2101357408 @default.
- W3000167470 cites W2101741807 @default.
- W3000167470 cites W2104135721 @default.
- W3000167470 cites W2104140249 @default.
- W3000167470 cites W2110233724 @default.
- W3000167470 cites W2112800219 @default.
- W3000167470 cites W2114103149 @default.
- W3000167470 cites W2118494910 @default.
- W3000167470 cites W2131051578 @default.
- W3000167470 cites W2131383874 @default.
- W3000167470 cites W2132286615 @default.
- W3000167470 cites W2136145485 @default.
- W3000167470 cites W2137881661 @default.
- W3000167470 cites W2138146369 @default.
- W3000167470 cites W2147320841 @default.
- W3000167470 cites W2151199834 @default.
- W3000167470 cites W2154514659 @default.
- W3000167470 cites W2155899899 @default.
- W3000167470 cites W2157583031 @default.
- W3000167470 cites W2162423225 @default.
- W3000167470 cites W2163274894 @default.
- W3000167470 cites W2166279530 @default.
- W3000167470 cites W2167279371 @default.
- W3000167470 cites W2168153190 @default.
- W3000167470 cites W2170170033 @default.
- W3000167470 cites W2177588396 @default.
- W3000167470 cites W2274549869 @default.
- W3000167470 cites W2339180010 @default.
- W3000167470 cites W2415803807 @default.
- W3000167470 cites W2417620349 @default.
- W3000167470 cites W2437503399 @default.
- W3000167470 cites W2485836676 @default.
- W3000167470 cites W2487019969 @default.