Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000169210> ?p ?o ?g. }
- W3000169210 abstract "Scope Non‐alcoholic fatty liver disease (NAFLD) among adolescents has been related to fructose intake. Additionally, maternal high‐fat diet (mHFD) increases the offspring susceptibility to NAFLD at adulthood. Here, it is hypothesized that mHFD may exacerbate the fructose impact in adolescent male rat offspring, by changing the response of contributing mechanisms to liver injury. Methods and results Female Wistar rats receive standard (mSTD: 9% fat) or high‐fat diet (mHFD: 29% fat) prior mating throughout pregnancy and lactation. After weaning, offspring receive standard chow and, from the 25th to 45th day, receive water or fructose–drinking water (15%). At 46 days old, fructose groups show increased adiposity, increased serum and hepatic triglycerides, regardless of maternal diet. Fructose aggravates the hepatic imbalance of redox state already exhibited by mHFD offspring. The hepatic activation of cellular repair pathways by fructose, such as unfolded protein response and macroautophagy, is disrupted only in mHFD offspring. Fructose does not change the liver morphology of mSTD offspring. However, it intensifies the liver injury already present in mHFD offspring. Conclusion Fructose intake during adolescence accelerates the emergence of NAFLD observed previously at the adult life of mHFD offspring, and reveals a differentiated hepatic response to metabolic insult, depending on the maternal diet." @default.
- W3000169210 created "2020-01-23" @default.
- W3000169210 creator A5001974092 @default.
- W3000169210 creator A5004325875 @default.
- W3000169210 creator A5004829143 @default.
- W3000169210 creator A5019848086 @default.
- W3000169210 creator A5040593914 @default.
- W3000169210 creator A5041183780 @default.
- W3000169210 creator A5045758451 @default.
- W3000169210 creator A5062577365 @default.
- W3000169210 creator A5068641092 @default.
- W3000169210 creator A5074572123 @default.
- W3000169210 creator A5083621919 @default.
- W3000169210 creator A5085579132 @default.
- W3000169210 creator A5089513094 @default.
- W3000169210 date "2020-01-16" @default.
- W3000169210 modified "2023-10-01" @default.
- W3000169210 title "Differentiated Hepatic Response to Fructose Intake during Adolescence Reveals the Increased Susceptibility to Non‐Alcoholic Fatty Liver Disease of Maternal High‐Fat Diet Male Rat Offspring" @default.
- W3000169210 cites W1532227953 @default.
- W3000169210 cites W1641968766 @default.
- W3000169210 cites W1831301545 @default.
- W3000169210 cites W1916400625 @default.
- W3000169210 cites W1988596878 @default.
- W3000169210 cites W1991386892 @default.
- W3000169210 cites W1994605397 @default.
- W3000169210 cites W2017948134 @default.
- W3000169210 cites W2040868013 @default.
- W3000169210 cites W2064216549 @default.
- W3000169210 cites W2067740038 @default.
- W3000169210 cites W2068640275 @default.
- W3000169210 cites W2076361507 @default.
- W3000169210 cites W2084598636 @default.
- W3000169210 cites W2090013838 @default.
- W3000169210 cites W2090379786 @default.
- W3000169210 cites W2091890107 @default.
- W3000169210 cites W2093398011 @default.
- W3000169210 cites W2096526724 @default.
- W3000169210 cites W2103868572 @default.
- W3000169210 cites W2105772435 @default.
- W3000169210 cites W2118823045 @default.
- W3000169210 cites W2120623114 @default.
- W3000169210 cites W2128764301 @default.
- W3000169210 cites W2130059167 @default.
- W3000169210 cites W2130326770 @default.
- W3000169210 cites W2133629517 @default.
- W3000169210 cites W2165578318 @default.
- W3000169210 cites W2257858317 @default.
- W3000169210 cites W2466673351 @default.
- W3000169210 cites W2543316248 @default.
- W3000169210 cites W2600086110 @default.
- W3000169210 cites W2752326209 @default.
- W3000169210 cites W2762755130 @default.
- W3000169210 cites W2766698329 @default.
- W3000169210 cites W2767859898 @default.
- W3000169210 cites W2781900985 @default.
- W3000169210 cites W2788821298 @default.
- W3000169210 cites W2793674749 @default.
- W3000169210 cites W2810290723 @default.
- W3000169210 cites W2892754220 @default.
- W3000169210 cites W2902072788 @default.
- W3000169210 cites W2912702057 @default.
- W3000169210 cites W2924326463 @default.
- W3000169210 cites W2926309915 @default.
- W3000169210 doi "https://doi.org/10.1002/mnfr.201900838" @default.
- W3000169210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31916388" @default.
- W3000169210 hasPublicationYear "2020" @default.
- W3000169210 type Work @default.
- W3000169210 sameAs 3000169210 @default.
- W3000169210 citedByCount "10" @default.
- W3000169210 countsByYear W30001692102020 @default.
- W3000169210 countsByYear W30001692102021 @default.
- W3000169210 countsByYear W30001692102022 @default.
- W3000169210 countsByYear W30001692102023 @default.
- W3000169210 crossrefType "journal-article" @default.
- W3000169210 hasAuthorship W3000169210A5001974092 @default.
- W3000169210 hasAuthorship W3000169210A5004325875 @default.
- W3000169210 hasAuthorship W3000169210A5004829143 @default.
- W3000169210 hasAuthorship W3000169210A5019848086 @default.
- W3000169210 hasAuthorship W3000169210A5040593914 @default.
- W3000169210 hasAuthorship W3000169210A5041183780 @default.
- W3000169210 hasAuthorship W3000169210A5045758451 @default.
- W3000169210 hasAuthorship W3000169210A5062577365 @default.
- W3000169210 hasAuthorship W3000169210A5068641092 @default.
- W3000169210 hasAuthorship W3000169210A5074572123 @default.
- W3000169210 hasAuthorship W3000169210A5083621919 @default.
- W3000169210 hasAuthorship W3000169210A5085579132 @default.
- W3000169210 hasAuthorship W3000169210A5089513094 @default.
- W3000169210 hasConcept C112672928 @default.
- W3000169210 hasConcept C126322002 @default.
- W3000169210 hasConcept C134018914 @default.
- W3000169210 hasConcept C2776659692 @default.
- W3000169210 hasConcept C2776954865 @default.
- W3000169210 hasConcept C2776970464 @default.
- W3000169210 hasConcept C2778772119 @default.
- W3000169210 hasConcept C2779134260 @default.
- W3000169210 hasConcept C2779234561 @default.
- W3000169210 hasConcept C2780655333 @default.
- W3000169210 hasConcept C42407357 @default.
- W3000169210 hasConcept C54355233 @default.
- W3000169210 hasConcept C55493867 @default.