Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000200045> ?p ?o ?g. }
- W3000200045 endingPage "242" @default.
- W3000200045 startingPage "235" @default.
- W3000200045 abstract "In recent years, increasing evidence of the cerebellar role in social cognition has emerged. The cerebellum has been shown to modulate cortical activity of social brain regions serving as a regulator of function-specific mentalizing and mirroring processes. In particular, a mentalizing area in the posterior cerebellum, specifically Crus II, is preferentially recruited for more complex and abstract forms of social processing, together with mentalizing cerebral areas including the dorsal medial prefrontal cortex (dmPFC), the temporo-parietal junction (TPJ), and the precuneus. In the present study, the network-based statistics approach was used to assess functional connectivity (FC) differences within this mentalizing cerebello-cerebral network associated with a specific cerebellar damage. To this aim, patients affected by spinocerebellar ataxia type 2 (SCA2), a neurodegenerative disease specifically affecting regions of the cerebellar cortex, and age-matched healthy subjects have been enrolled. The dmPFC, left and right TPJ, the precuneus, and the cerebellar Crus II were used as regions of interest to construct the mentalizing network to be analyzed and evaluate pairwise functional relations between them. When compared with controls, SCA2 patients showed altered internodal connectivity between dmPFC, left (L-) and right (R-) TPJ, and right posterior cerebellar Crus II. The present results indicate that FC changes affect a function-specific mentalizing network in patients affected by cerebellar damage. In particular, they allow to better clarify functional alteration mechanisms driven by the cerebellar damage associated with SCA2 suggesting that selective cortico-cerebellar functional disconnections may underlie patients’ social impairment in domain-specific complex and abstract forms of social functioning." @default.
- W3000200045 created "2020-01-23" @default.
- W3000200045 creator A5018858651 @default.
- W3000200045 creator A5032032723 @default.
- W3000200045 creator A5039977256 @default.
- W3000200045 creator A5047914446 @default.
- W3000200045 creator A5050297766 @default.
- W3000200045 creator A5059388096 @default.
- W3000200045 creator A5078205854 @default.
- W3000200045 creator A5078468204 @default.
- W3000200045 creator A5085369499 @default.
- W3000200045 creator A5087821155 @default.
- W3000200045 date "2020-01-10" @default.
- W3000200045 modified "2023-10-06" @default.
- W3000200045 title "Functional Changes of Mentalizing Network in SCA2 Patients: Novel Insights into Understanding the Social Cerebellum" @default.
- W3000200045 cites W1564664134 @default.
- W3000200045 cites W1667569286 @default.
- W3000200045 cites W1975199418 @default.
- W3000200045 cites W1976005699 @default.
- W3000200045 cites W1981786093 @default.
- W3000200045 cites W1992214067 @default.
- W3000200045 cites W1994643490 @default.
- W3000200045 cites W2000917789 @default.
- W3000200045 cites W2005821483 @default.
- W3000200045 cites W2009794136 @default.
- W3000200045 cites W2014914276 @default.
- W3000200045 cites W2018667648 @default.
- W3000200045 cites W2035678379 @default.
- W3000200045 cites W2043288745 @default.
- W3000200045 cites W2044724657 @default.
- W3000200045 cites W2047266773 @default.
- W3000200045 cites W2051134167 @default.
- W3000200045 cites W2051879624 @default.
- W3000200045 cites W2056691365 @default.
- W3000200045 cites W2060899536 @default.
- W3000200045 cites W2067456724 @default.
- W3000200045 cites W2069221001 @default.
- W3000200045 cites W2086363563 @default.
- W3000200045 cites W2088980803 @default.
- W3000200045 cites W2090017477 @default.
- W3000200045 cites W2090588457 @default.
- W3000200045 cites W2106163392 @default.
- W3000200045 cites W2111613011 @default.
- W3000200045 cites W2116526527 @default.
- W3000200045 cites W2122535408 @default.
- W3000200045 cites W2126334133 @default.
- W3000200045 cites W2126395049 @default.
- W3000200045 cites W2126838454 @default.
- W3000200045 cites W2128595931 @default.
- W3000200045 cites W2128906604 @default.
- W3000200045 cites W2145439917 @default.
- W3000200045 cites W2149795074 @default.
- W3000200045 cites W2153254791 @default.
- W3000200045 cites W2161192362 @default.
- W3000200045 cites W2162010696 @default.
- W3000200045 cites W2411243585 @default.
- W3000200045 cites W2412756677 @default.
- W3000200045 cites W2601799066 @default.
- W3000200045 cites W2615809677 @default.
- W3000200045 cites W2751668458 @default.
- W3000200045 cites W2760867613 @default.
- W3000200045 cites W2765189146 @default.
- W3000200045 cites W2773669959 @default.
- W3000200045 cites W2784424727 @default.
- W3000200045 cites W2792190214 @default.
- W3000200045 cites W2807742319 @default.
- W3000200045 cites W2884296928 @default.
- W3000200045 cites W2894785843 @default.
- W3000200045 cites W2900097314 @default.
- W3000200045 cites W2903999437 @default.
- W3000200045 cites W2904820430 @default.
- W3000200045 cites W2918246134 @default.
- W3000200045 cites W2943456378 @default.
- W3000200045 cites W2946425363 @default.
- W3000200045 cites W4233994114 @default.
- W3000200045 cites W4295750005 @default.
- W3000200045 doi "https://doi.org/10.1007/s12311-019-01081-x" @default.
- W3000200045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31925668" @default.
- W3000200045 hasPublicationYear "2020" @default.
- W3000200045 type Work @default.
- W3000200045 sameAs 3000200045 @default.
- W3000200045 citedByCount "16" @default.
- W3000200045 countsByYear W30002000452020 @default.
- W3000200045 countsByYear W30002000452021 @default.
- W3000200045 countsByYear W30002000452022 @default.
- W3000200045 countsByYear W30002000452023 @default.
- W3000200045 crossrefType "journal-article" @default.
- W3000200045 hasAuthorship W3000200045A5018858651 @default.
- W3000200045 hasAuthorship W3000200045A5032032723 @default.
- W3000200045 hasAuthorship W3000200045A5039977256 @default.
- W3000200045 hasAuthorship W3000200045A5047914446 @default.
- W3000200045 hasAuthorship W3000200045A5050297766 @default.
- W3000200045 hasAuthorship W3000200045A5059388096 @default.
- W3000200045 hasAuthorship W3000200045A5078205854 @default.
- W3000200045 hasAuthorship W3000200045A5078468204 @default.
- W3000200045 hasAuthorship W3000200045A5085369499 @default.
- W3000200045 hasAuthorship W3000200045A5087821155 @default.
- W3000200045 hasBestOaLocation W30002000452 @default.