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- W3000220120 abstract "Outer membrane vesicles (OMVs) are spherical liposomes that are secreted by almost all forms of Gram-negative bacteria. The nanospheres contribute to bacterial pathogenesis by trafficking molecular cargo from bacterial membranes to target cells at the host-pathogen interface. We have simulated the interaction of OMVs with host cell membranes to understand why OMV uptake depends on the length of constituent lipopolysaccharide macromolecules. Using coarse-grained molecular dynamics simulations, we show that lipopolysaccharide lipid length affects OMV shape at the host-pathogen interface: OMVs with long (smooth-type) lipopolysaccharide lipids retain their spherical shape when they interact with host cell membranes, whereas OMVs with shorter (rough-type) lipopolysaccharide lipids distort and spread over the host membrane surface. In addition, we show that OMVs preferentially coordinate domain-favoring ganglioside lipids within host membranes to enhance curvature and affect the local lipid composition. We predict that these differences in shape preservation affect OMV internalization on long timescales: spherical nanoparticles tend to be completely enveloped by host membranes, whereas low sphericity nanoparticles tend to remain on the surface of cells." @default.
- W3000220120 created "2020-01-23" @default.
- W3000220120 creator A5079670006 @default.
- W3000220120 creator A5091803044 @default.
- W3000220120 date "2020-02-01" @default.
- W3000220120 modified "2023-10-12" @default.
- W3000220120 title "To infect or not to infect: molecular determinants of bacterial outer membrane vesicle internalization by host membranes" @default.
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- W3000220120 doi "https://doi.org/10.1016/j.jmb.2020.01.008" @default.
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