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- W3000220133 abstract "Abstract Ginsenosides exhibit a large variety of biological activities in maintaining physical health; however, the molecule underpinnings underlining these biological activities remain to be defined. Here, we took a cellular condition that compound K (CK) induces autophagic cell death in HeLa cells, and setup a high-throughput genetic screening using CRISPR technology. We have identified a number of CK-resistant and CK-sensitive genes, and further validated PMAIP1 as a CK-resistant gene and WASH1 as a CK-sensitive gene. Compound K treatment reduces the expression of WASH1, which further accelerates the autophagic cell death, highlighting WASH1 as an interesting downstream mediator of CK effects. Overall, our study offers an easy-to-adopt platform to study the functional mediators of ginsenosides, and provides a candidate list of genes that are potential targets of CK." @default.
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- W3000220133 date "2020-01-20" @default.
- W3000220133 modified "2023-10-09" @default.
- W3000220133 title "Genome-scale CRISPR screening for potential targets of ginsenoside compound K" @default.
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- W3000220133 doi "https://doi.org/10.1038/s41419-020-2234-5" @default.
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