Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000222029> ?p ?o ?g. }
- W3000222029 endingPage "250" @default.
- W3000222029 startingPage "250" @default.
- W3000222029 abstract "Disseminated metastatic cancer cells represent one of the most relevant causes of disease relapse and associated death for cancer patients, and a therapeutic target of the highest priority. Still, our understanding of how disseminated cancer cells survive in the foreign metastatic environment, and eventually cause metastatic outgrowth, remains rather limited. In this review we focus on the cell microenvironment as a key regulator of cell behavior at the metastatic site, and especially on the mechanical properties of the extracellular matrix and associated integrin signaling. We discuss available evidence pointing to a pervasive role of extracellular matrix (ECM) mechanical properties in regulating cancer cell proliferation and survival after dissemination, and propose that this might represent an important bottleneck for cells invading and establishing into a novel tissue. We point to the known molecular players, how these might contribute to modulate the mechanical properties of the metastatic environment, and the response of cells to these cues. Finally, we propose that emerging knowledge on the physical interaction of disseminated metastatic cells and on the downstream mechanotransduction pathways, including YAP/TAZ (Yes-associated protein-1 and WW-domain transcription activator 1) and MRTFs (Myocardin-related transcription factors), may help to identify novel approaches for therapy." @default.
- W3000222029 created "2020-01-23" @default.
- W3000222029 creator A5032170083 @default.
- W3000222029 creator A5042017056 @default.
- W3000222029 date "2020-01-19" @default.
- W3000222029 modified "2023-10-01" @default.
- W3000222029 title "Mechanical Forces as Determinants of Disseminated Metastatic Cell Fate" @default.
- W3000222029 cites W1760215417 @default.
- W3000222029 cites W1863585495 @default.
- W3000222029 cites W1868626511 @default.
- W3000222029 cites W1936732090 @default.
- W3000222029 cites W1967120404 @default.
- W3000222029 cites W1970199527 @default.
- W3000222029 cites W1970570245 @default.
- W3000222029 cites W1970811697 @default.
- W3000222029 cites W1972076214 @default.
- W3000222029 cites W1975132186 @default.
- W3000222029 cites W1979069664 @default.
- W3000222029 cites W1986471913 @default.
- W3000222029 cites W1988475719 @default.
- W3000222029 cites W1990668551 @default.
- W3000222029 cites W1993322072 @default.
- W3000222029 cites W1994683536 @default.
- W3000222029 cites W1995592152 @default.
- W3000222029 cites W2002196386 @default.
- W3000222029 cites W2016126437 @default.
- W3000222029 cites W2019645677 @default.
- W3000222029 cites W2022616393 @default.
- W3000222029 cites W2024315189 @default.
- W3000222029 cites W2030637965 @default.
- W3000222029 cites W2032392940 @default.
- W3000222029 cites W2033363278 @default.
- W3000222029 cites W2044339772 @default.
- W3000222029 cites W2054612304 @default.
- W3000222029 cites W2055940657 @default.
- W3000222029 cites W2056040807 @default.
- W3000222029 cites W2056391185 @default.
- W3000222029 cites W2057025275 @default.
- W3000222029 cites W2059653502 @default.
- W3000222029 cites W2060934353 @default.
- W3000222029 cites W2061058076 @default.
- W3000222029 cites W2063290334 @default.
- W3000222029 cites W2068310937 @default.
- W3000222029 cites W2082239705 @default.
- W3000222029 cites W2086336177 @default.
- W3000222029 cites W2087654007 @default.
- W3000222029 cites W2090392605 @default.
- W3000222029 cites W2090898517 @default.
- W3000222029 cites W2090937459 @default.
- W3000222029 cites W2093723806 @default.
- W3000222029 cites W2094279499 @default.
- W3000222029 cites W2097862336 @default.
- W3000222029 cites W2098692163 @default.
- W3000222029 cites W2099052265 @default.
- W3000222029 cites W2100113004 @default.
- W3000222029 cites W2100122781 @default.
- W3000222029 cites W2100303404 @default.
- W3000222029 cites W2101335366 @default.
- W3000222029 cites W2102661335 @default.
- W3000222029 cites W2102707911 @default.
- W3000222029 cites W2104479723 @default.
- W3000222029 cites W2104913188 @default.
- W3000222029 cites W2106263242 @default.
- W3000222029 cites W2106572080 @default.
- W3000222029 cites W2106738771 @default.
- W3000222029 cites W2111414495 @default.
- W3000222029 cites W2115900736 @default.
- W3000222029 cites W2118671972 @default.
- W3000222029 cites W2118821583 @default.
- W3000222029 cites W2130201056 @default.
- W3000222029 cites W2135726634 @default.
- W3000222029 cites W2139689409 @default.
- W3000222029 cites W2141595533 @default.
- W3000222029 cites W2145731759 @default.
- W3000222029 cites W2146078095 @default.
- W3000222029 cites W2148528535 @default.
- W3000222029 cites W2154706646 @default.
- W3000222029 cites W2154841339 @default.
- W3000222029 cites W2155390148 @default.
- W3000222029 cites W2155542819 @default.
- W3000222029 cites W2157215186 @default.
- W3000222029 cites W2159744630 @default.
- W3000222029 cites W2161862739 @default.
- W3000222029 cites W2163472474 @default.
- W3000222029 cites W2167978765 @default.
- W3000222029 cites W2303653884 @default.
- W3000222029 cites W2328524037 @default.
- W3000222029 cites W2337683177 @default.
- W3000222029 cites W2345787662 @default.
- W3000222029 cites W2410819293 @default.
- W3000222029 cites W2426003472 @default.
- W3000222029 cites W2470710219 @default.
- W3000222029 cites W2510922180 @default.
- W3000222029 cites W2515910706 @default.
- W3000222029 cites W2522829580 @default.
- W3000222029 cites W2525346244 @default.
- W3000222029 cites W2551462252 @default.
- W3000222029 cites W2552754421 @default.