FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000223848> ?p ?o ?g. }

• W3000223848 endingPage "20190966" @default.
• W3000223848 startingPage "20190966" @default.
• W3000223848 abstract "The significance of canonical DNA non-homologous end-joining (c-NHEJ) for DNA double strand break (DSB) repair has increased from lower organisms to higher eukaryotes, and plays the predominant role in human cells. Ku, the c-NHEJ end-binding component, binds DSBs with high efficiency enabling c-NHEJ to be the first choice DSB repair pathway, although alternative pathways can ensue after regulated steps to remove Ku. Indeed, radiation-induced DSBs are repaired rapidly in human cells. However, an important question is the fidelity with which radiation-induced DSBs are repaired, which is essential for assessing any harmful impacts caused by radiation exposure. Indeed, is compromised fidelity a price we pay for high capacity repair. Two subpathways of c-NHEJ have been revealed; a fast process that does not require nucleases or significant chromatin changes and a slower process that necessitates resection factors, and potentially more significant chromatin changes at the DSB. Recent studies have also shown that DSBs within transcriptionally active regions are repaired by specialised mechanisms, and the response at such DSBs encompasses a process of transcriptional arrest. Here, we consider the limitations of c-NHEJ that might result in DSB misrepair. We consider the common IR-induced misrepair events and discuss how they might arise via the distinct subpathways of c-NHEJ." @default.
• W3000223848 created "2020-01-23" @default.
• W3000223848 creator A5073128750 @default.
• W3000223848 creator A5078309099 @default.
• W3000223848 date "2020-11-01" @default.
• W3000223848 modified "2023-09-26" @default.
• W3000223848 title "Canonical DNA non-homologous end-joining; capacity versus fidelity" @default.
• W3000223848 cites W1968469516 @default.
• W3000223848 cites W1979568780 @default.
• W3000223848 cites W1984881284 @default.
• W3000223848 cites W1993026474 @default.
• W3000223848 cites W2005128568 @default.
• W3000223848 cites W2019292967 @default.
• W3000223848 cites W2033172828 @default.
• W3000223848 cites W2039201797 @default.
• W3000223848 cites W2054646144 @default.
• W3000223848 cites W2080290623 @default.
• W3000223848 cites W2081122699 @default.
• W3000223848 cites W2094020226 @default.
• W3000223848 cites W2117602431 @default.
• W3000223848 cites W2129248613 @default.
• W3000223848 cites W2134807701 @default.
• W3000223848 cites W2140186362 @default.
• W3000223848 cites W2140345256 @default.
• W3000223848 cites W2165034310 @default.
• W3000223848 cites W2169768109 @default.
• W3000223848 cites W2324597012 @default.
• W3000223848 cites W2520931435 @default.
• W3000223848 cites W2568713976 @default.
• W3000223848 cites W2580248979 @default.
• W3000223848 cites W2600149168 @default.
• W3000223848 cites W2737595608 @default.
• W3000223848 cites W2753229012 @default.
• W3000223848 cites W2888731769 @default.
• W3000223848 cites W2889676858 @default.
• W3000223848 cites W2907154066 @default.
• W3000223848 cites W2938255062 @default.
• W3000223848 cites W2982257042 @default.
• W3000223848 doi "https://doi.org/10.1259/bjr.20190966" @default.
• W3000223848 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8519634" @default.
• W3000223848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31944860" @default.
• W3000223848 hasPublicationYear "2020" @default.
• W3000223848 type Work @default.
• W3000223848 sameAs 3000223848 @default.
• W3000223848 citedByCount "22" @default.
• W3000223848 countsByYear W30002238482020 @default.
• W3000223848 countsByYear W30002238482021 @default.
• W3000223848 countsByYear W30002238482022 @default.
• W3000223848 countsByYear W30002238482023 @default.
• W3000223848 crossrefType "journal-article" @default.
• W3000223848 hasAuthorship W3000223848A5073128750 @default.
• W3000223848 hasAuthorship W3000223848A5078309099 @default.
• W3000223848 hasBestOaLocation W30002238481 @default.
• W3000223848 hasConcept C102744134 @default.
• W3000223848 hasConcept C104317684 @default.
• W3000223848 hasConcept C122917832 @default.
• W3000223848 hasConcept C134935766 @default.
• W3000223848 hasConcept C143425029 @default.
• W3000223848 hasConcept C2992406208 @default.
• W3000223848 hasConcept C54355233 @default.
• W3000223848 hasConcept C552990157 @default.
• W3000223848 hasConcept C64894306 @default.
• W3000223848 hasConcept C70721500 @default.
• W3000223848 hasConcept C83640560 @default.
• W3000223848 hasConcept C86803240 @default.
• W3000223848 hasConcept C95444343 @default.
• W3000223848 hasConceptScore W3000223848C102744134 @default.
• W3000223848 hasConceptScore W3000223848C104317684 @default.
• W3000223848 hasConceptScore W3000223848C122917832 @default.
• W3000223848 hasConceptScore W3000223848C134935766 @default.
• W3000223848 hasConceptScore W3000223848C143425029 @default.
• W3000223848 hasConceptScore W3000223848C2992406208 @default.
• W3000223848 hasConceptScore W3000223848C54355233 @default.
• W3000223848 hasConceptScore W3000223848C552990157 @default.
• W3000223848 hasConceptScore W3000223848C64894306 @default.
• W3000223848 hasConceptScore W3000223848C70721500 @default.
• W3000223848 hasConceptScore W3000223848C83640560 @default.
• W3000223848 hasConceptScore W3000223848C86803240 @default.
• W3000223848 hasConceptScore W3000223848C95444343 @default.
• W3000223848 hasIssue "1115" @default.
• W3000223848 hasLocation W30002238481 @default.
• W3000223848 hasLocation W30002238482 @default.
• W3000223848 hasLocation W30002238483 @default.
• W3000223848 hasOpenAccess W3000223848 @default.
• W3000223848 hasPrimaryLocation W30002238481 @default.
• W3000223848 hasRelatedWork W2053822327 @default.
• W3000223848 hasRelatedWork W2099588420 @default.
• W3000223848 hasRelatedWork W2115427429 @default.
• W3000223848 hasRelatedWork W2161452450 @default.
• W3000223848 hasRelatedWork W2325419886 @default.
• W3000223848 hasRelatedWork W2401497319 @default.
• W3000223848 hasRelatedWork W2522427913 @default.
• W3000223848 hasRelatedWork W2736937294 @default.
• W3000223848 hasRelatedWork W2761625598 @default.
• W3000223848 hasRelatedWork W3011248839 @default.
• W3000223848 hasVolume "93" @default.
• W3000223848 isParatext "false" @default.
• W3000223848 isRetracted "false" @default.

• next