Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000225811> ?p ?o ?g. }
- W3000225811 abstract "ABSTRACT Background To determine whether fluorodeoxyglucose positron emission tomography (FDG-PET) could differentiate between responding and non-responding locally advanced esophageal squamous cell carcinoma (ESCC) early in the course of neoadjuvant chemoradiotherapy (CRT). Methods Patients with T3 or N1M0-1a (AJCC, 6th ed.) ESCC first received a 21-day cycle of induction CT with paclitaxel, cisplatin, 5-FU/leucovorin D 1, 8). This was followed by concurrent paclitaxel, cisplatin CRT (Lin CC et al. Ann Oncol 18: 93; 2007). When the accumulated RT dose reached 40 Gy, the feasibility of esophagectomy was evaluated. In patients for whom esophagectomy was not feasible, CCRT was continued to a dose of 60 Gy. Serial FDG-PETs were carried out before and 14 days after the start of induction CT. Pathologic response (PR) was defined as no or microscopic residual disease. PET response was measured using the standardized uptake value (SUV). Receiver operating characteristic (ROC) analysis was used to evaluate the SUV ability in distinguishing between PR and non-PR. Results Of 65 patients (M:F = 60:5, median age 55, range 39–71) with locally advanced (M0:M1a = 58:7) ESCC enrolled from March 2008 to December 2011, 40 patients underwent esophagectomy and 26 patients were pathologic responders. The median SUV decrease 140 days after the start of therapy was 75.8% for pathologic responders and 30.1% for non-responders (P Conclusions A 35% SUV decrease 14 days after the start of induction CT is significantly associated with PR, but its accuracy in detecting non-responders is too low to justify the clinical use of FDG-PET for early discontinuation of neoadjuvant CRT in patients with locally advanced ESCC." @default.
- W3000225811 created "2020-01-23" @default.
- W3000225811 creator A5014645228 @default.
- W3000225811 creator A5020674154 @default.
- W3000225811 creator A5025213023 @default.
- W3000225811 creator A5026732484 @default.
- W3000225811 creator A5029171331 @default.
- W3000225811 creator A5031236432 @default.
- W3000225811 creator A5046799249 @default.
- W3000225811 creator A5048538551 @default.
- W3000225811 creator A5070004463 @default.
- W3000225811 creator A5083799225 @default.
- W3000225811 creator A5087946333 @default.
- W3000225811 date "2012-10-01" @default.
- W3000225811 modified "2023-09-27" @default.
- W3000225811 title "Fluorodeoxyglucose Positron Emission Tomography for Evaluating Early Response During Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma" @default.
- W3000225811 doi "https://doi.org/10.1016/s0923-7534(20)32047-0" @default.
- W3000225811 hasPublicationYear "2012" @default.
- W3000225811 type Work @default.
- W3000225811 sameAs 3000225811 @default.
- W3000225811 citedByCount "0" @default.
- W3000225811 crossrefType "journal-article" @default.
- W3000225811 hasAuthorship W3000225811A5014645228 @default.
- W3000225811 hasAuthorship W3000225811A5020674154 @default.
- W3000225811 hasAuthorship W3000225811A5025213023 @default.
- W3000225811 hasAuthorship W3000225811A5026732484 @default.
- W3000225811 hasAuthorship W3000225811A5029171331 @default.
- W3000225811 hasAuthorship W3000225811A5031236432 @default.
- W3000225811 hasAuthorship W3000225811A5046799249 @default.
- W3000225811 hasAuthorship W3000225811A5048538551 @default.
- W3000225811 hasAuthorship W3000225811A5070004463 @default.
- W3000225811 hasAuthorship W3000225811A5083799225 @default.
- W3000225811 hasAuthorship W3000225811A5087946333 @default.
- W3000225811 hasBestOaLocation W30002258111 @default.
- W3000225811 hasConcept C121608353 @default.
- W3000225811 hasConcept C126322002 @default.
- W3000225811 hasConcept C126838900 @default.
- W3000225811 hasConcept C199374082 @default.
- W3000225811 hasConcept C2775842073 @default.
- W3000225811 hasConcept C2776611710 @default.
- W3000225811 hasConcept C2776694085 @default.
- W3000225811 hasConcept C2777292972 @default.
- W3000225811 hasConcept C2777297899 @default.
- W3000225811 hasConcept C2777415128 @default.
- W3000225811 hasConcept C2777546739 @default.
- W3000225811 hasConcept C2778239845 @default.
- W3000225811 hasConcept C2778292576 @default.
- W3000225811 hasConcept C2778424827 @default.
- W3000225811 hasConcept C2779742542 @default.
- W3000225811 hasConcept C2989005 @default.
- W3000225811 hasConcept C2994415158 @default.
- W3000225811 hasConcept C509974204 @default.
- W3000225811 hasConcept C530470458 @default.
- W3000225811 hasConcept C71924100 @default.
- W3000225811 hasConceptScore W3000225811C121608353 @default.
- W3000225811 hasConceptScore W3000225811C126322002 @default.
- W3000225811 hasConceptScore W3000225811C126838900 @default.
- W3000225811 hasConceptScore W3000225811C199374082 @default.
- W3000225811 hasConceptScore W3000225811C2775842073 @default.
- W3000225811 hasConceptScore W3000225811C2776611710 @default.
- W3000225811 hasConceptScore W3000225811C2776694085 @default.
- W3000225811 hasConceptScore W3000225811C2777292972 @default.
- W3000225811 hasConceptScore W3000225811C2777297899 @default.
- W3000225811 hasConceptScore W3000225811C2777415128 @default.
- W3000225811 hasConceptScore W3000225811C2777546739 @default.
- W3000225811 hasConceptScore W3000225811C2778239845 @default.
- W3000225811 hasConceptScore W3000225811C2778292576 @default.
- W3000225811 hasConceptScore W3000225811C2778424827 @default.
- W3000225811 hasConceptScore W3000225811C2779742542 @default.
- W3000225811 hasConceptScore W3000225811C2989005 @default.
- W3000225811 hasConceptScore W3000225811C2994415158 @default.
- W3000225811 hasConceptScore W3000225811C509974204 @default.
- W3000225811 hasConceptScore W3000225811C530470458 @default.
- W3000225811 hasConceptScore W3000225811C71924100 @default.
- W3000225811 hasLocation W30002258111 @default.
- W3000225811 hasLocation W30002258112 @default.
- W3000225811 hasOpenAccess W3000225811 @default.
- W3000225811 hasPrimaryLocation W30002258111 @default.
- W3000225811 hasRelatedWork W1013881558 @default.
- W3000225811 hasRelatedWork W125100881 @default.
- W3000225811 hasRelatedWork W1944736642 @default.
- W3000225811 hasRelatedWork W1996043820 @default.
- W3000225811 hasRelatedWork W1998723586 @default.
- W3000225811 hasRelatedWork W2003033986 @default.
- W3000225811 hasRelatedWork W2031936372 @default.
- W3000225811 hasRelatedWork W2054409954 @default.
- W3000225811 hasRelatedWork W2062506284 @default.
- W3000225811 hasRelatedWork W218559851 @default.
- W3000225811 hasRelatedWork W2256178789 @default.
- W3000225811 hasRelatedWork W2264649830 @default.
- W3000225811 hasRelatedWork W2275434694 @default.
- W3000225811 hasRelatedWork W2413331746 @default.
- W3000225811 hasRelatedWork W2792710836 @default.
- W3000225811 hasRelatedWork W2889256929 @default.
- W3000225811 hasRelatedWork W2990273116 @default.
- W3000225811 hasRelatedWork W3009044412 @default.
- W3000225811 hasRelatedWork W3076324114 @default.
- W3000225811 hasRelatedWork W3160287582 @default.
- W3000225811 isParatext "false" @default.
- W3000225811 isRetracted "false" @default.