FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000239768> ?p ?o ?g. }

• W3000239768 endingPage "133" @default.
• W3000239768 startingPage "127" @default.
• W3000239768 abstract "Certain D2-like dopamine receptor (DR) agonists are useful therapeutically as antiparkinsonian drugs, whereas D2-like DR antagonists or partial agonists are proven effective as antipsychotics. Two isoquinoline derivatives, 1-(2′-bromobenzyl)-6,7-dihydroxy-N-methyl-tetrahydroisoquinoline (Br-BTHIQ, 1) and 1,2-demethyl-nuciferine (aporphine, 2), were herein synthesized, and their dopaminergic affinity in cloned human D2R, D3R, and D4R subtypes and their behavior as agonists/antagonists were evaluated. They showed affinity values (Ki) for hD2, hD3, and hD4 DR within the nanomolar range. The trends in affinity were hD4R ≫ hD3R > hD2R for Br-BTHIQ (1) and hD2R > hD4R > hD3R for 1,2-demethyl-nuciferine (2). The functional assays of cyclic adenosine monophosphate signaling at human D2R showed a partial agonist effect for Br-BTHIQ (1) and full agonist behavior for aporphine (2), with half maximal effective concentration values of 2.95 and 10.2 μM, respectively. Therefore, both isoquinolines 1 and 2 have emerged as lead molecules for the synthesis of new therapeutic drugs that ultimately may be useful to prevent schizophrenia and Parkinson’s disease, respectively." @default.
• W3000239768 created "2020-01-23" @default.
• W3000239768 creator A5001713307 @default.
• W3000239768 creator A5006024581 @default.
• W3000239768 creator A5009542582 @default.
• W3000239768 creator A5018243559 @default.
• W3000239768 creator A5027134593 @default.
• W3000239768 creator A5054542297 @default.
• W3000239768 creator A5061857061 @default.
• W3000239768 creator A5069220879 @default.
• W3000239768 creator A5069307292 @default.
• W3000239768 date "2020-01-14" @default.
• W3000239768 modified "2023-10-18" @default.
• W3000239768 title "1-(2′-Bromobenzyl)-6,7-dihydroxy-<i>N</i>-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D₂ Dopamine Receptors" @default.
• W3000239768 cites W1786514222 @default.
• W3000239768 cites W1925492557 @default.
• W3000239768 cites W1977212555 @default.
• W3000239768 cites W1986316632 @default.
• W3000239768 cites W1988026123 @default.
• W3000239768 cites W1989229828 @default.
• W3000239768 cites W1989562229 @default.
• W3000239768 cites W1991598332 @default.
• W3000239768 cites W2010972570 @default.
• W3000239768 cites W2040905203 @default.
• W3000239768 cites W2042435043 @default.
• W3000239768 cites W2054786261 @default.
• W3000239768 cites W2062506524 @default.
• W3000239768 cites W2067155858 @default.
• W3000239768 cites W2072679875 @default.
• W3000239768 cites W2073763568 @default.
• W3000239768 cites W2074658860 @default.
• W3000239768 cites W2078104068 @default.
• W3000239768 cites W2083323215 @default.
• W3000239768 cites W2083763857 @default.
• W3000239768 cites W2104961861 @default.
• W3000239768 cites W2112500009 @default.
• W3000239768 cites W2127800696 @default.
• W3000239768 cites W2130208417 @default.
• W3000239768 cites W2161077775 @default.
• W3000239768 cites W2163607604 @default.
• W3000239768 cites W2166597021 @default.
• W3000239768 cites W2168954492 @default.
• W3000239768 cites W2295477436 @default.
• W3000239768 cites W2766694609 @default.
• W3000239768 cites W2785023044 @default.
• W3000239768 cites W2898942138 @default.
• W3000239768 cites W2899995442 @default.
• W3000239768 doi "https://doi.org/10.1021/acs.jnatprod.9b00921" @default.
• W3000239768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31933369" @default.
• W3000239768 hasPublicationYear "2020" @default.
• W3000239768 type Work @default.
• W3000239768 sameAs 3000239768 @default.
• W3000239768 citedByCount "8" @default.
• W3000239768 countsByYear W30002397682020 @default.
• W3000239768 countsByYear W30002397682021 @default.
• W3000239768 countsByYear W30002397682022 @default.
• W3000239768 countsByYear W30002397682023 @default.
• W3000239768 crossrefType "journal-article" @default.
• W3000239768 hasAuthorship W3000239768A5001713307 @default.
• W3000239768 hasAuthorship W3000239768A5006024581 @default.
• W3000239768 hasAuthorship W3000239768A5009542582 @default.
• W3000239768 hasAuthorship W3000239768A5018243559 @default.
• W3000239768 hasAuthorship W3000239768A5027134593 @default.
• W3000239768 hasAuthorship W3000239768A5054542297 @default.
• W3000239768 hasAuthorship W3000239768A5061857061 @default.
• W3000239768 hasAuthorship W3000239768A5069220879 @default.
• W3000239768 hasAuthorship W3000239768A5069307292 @default.
• W3000239768 hasConcept C120069818 @default.
• W3000239768 hasConcept C126322002 @default.
• W3000239768 hasConcept C137183658 @default.
• W3000239768 hasConcept C170493617 @default.
• W3000239768 hasConcept C185592680 @default.
• W3000239768 hasConcept C2776923262 @default.
• W3000239768 hasConcept C2777667214 @default.
• W3000239768 hasConcept C2778079118 @default.
• W3000239768 hasConcept C2778938600 @default.
• W3000239768 hasConcept C44208683 @default.
• W3000239768 hasConcept C513476851 @default.
• W3000239768 hasConcept C55493867 @default.
• W3000239768 hasConcept C58732023 @default.
• W3000239768 hasConcept C71240020 @default.
• W3000239768 hasConcept C71924100 @default.
• W3000239768 hasConcept C86803240 @default.
• W3000239768 hasConcept C98274493 @default.
• W3000239768 hasConceptScore W3000239768C120069818 @default.
• W3000239768 hasConceptScore W3000239768C126322002 @default.
• W3000239768 hasConceptScore W3000239768C137183658 @default.
• W3000239768 hasConceptScore W3000239768C170493617 @default.
• W3000239768 hasConceptScore W3000239768C185592680 @default.
• W3000239768 hasConceptScore W3000239768C2776923262 @default.
• W3000239768 hasConceptScore W3000239768C2777667214 @default.
• W3000239768 hasConceptScore W3000239768C2778079118 @default.
• W3000239768 hasConceptScore W3000239768C2778938600 @default.
• W3000239768 hasConceptScore W3000239768C44208683 @default.
• W3000239768 hasConceptScore W3000239768C513476851 @default.
• W3000239768 hasConceptScore W3000239768C55493867 @default.
• W3000239768 hasConceptScore W3000239768C58732023 @default.
• W3000239768 hasConceptScore W3000239768C71240020 @default.

• next