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- W3000242432 abstract "ABSTRACT Background NGR-hTNF (asn-gly-arg-human tumor necrosis factor) induces antitumor effects by selectively damaging tumor neovasculature and increasing intratumoral infiltration of effector T cells. We investigated whether pretreatment PBLC values were associated with treatment outcomes in 5 phase II single-arm trials on 205 patients (pts) who were refractory/resistant to standard therapies. Methods NGR-hTNF 0.8 µg/m2 was given every 3 weeks (q3w) alone in pts with malignant pleural mesothelioma (MPM n = 55), hepatocellular carcinoma (HCC n = 40), and colorectal cancer (CRC n = 45), or combined with doxorubicin in small-cell lung cancer (SCLC n = 28) and ovarian cancer (OC n = 37). Tumor assessment by RECIST was done q6w until progression. Kaplan-Meier methods and Cox models were used to determine univariate and multivariate associations between baseline PBLC and progression-free survival (PFS) and overall survival (OS). Results Median baseline PBLC value was 1.4/mL (range 0.3-6.9; interquartile range 1.0-1.8) in 198 pts with available pretreatment counts. The first distribution quartile was used as cut-off value to dichotomize PBLC into high (≥ 1.0; n = 144, 73%) or low ( 1.8/mL were 7.7, 9.1, and 16.7 months, respectively (p Conclusions Pretreatment PBLC value may be used to identify which patients are likely to gain treatment benefit from NGR-hTNF. Disclosure C. Bordignon: Employment - MolMed. All other authors have declared no conflicts of interest." @default.
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- W3000242432 date "2012-09-01" @default.
- W3000242432 modified "2023-09-30" @default.
- W3000242432 title "Association Between Peripheral Blood Lymphocyte Count (PBLC) and Outcome in Patients with Solid Tumors Treated with Ngr-Htnf" @default.
- W3000242432 doi "https://doi.org/10.1016/s0923-7534(20)33065-9" @default.
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