FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3000269518> ?p ?o ?g. }

• W3000269518 endingPage "1355" @default.
• W3000269518 startingPage "1339" @default.
• W3000269518 abstract "Trichloroethylene (TCE) is a widespread environmental contaminant following decades of use as an industrial solvent, improper disposal, and remediation challenges. Consequently, TCE exposure continues to constitute a risk to human health. Despite epidemiological evidence associating exposure with adverse birth outcomes, the effects of TCE and its metabolite S-(1, 2-dichlorovinyl)-L-cysteine (DCVC) on the placenta remain undetermined. Flexible and efficient macronutrient and energy metabolism pathway utilization is essential for placental cell physiological adaptability. Because DCVC is known to compromise cellular energy status and disrupt energy metabolism in renal proximal tubular cells, this study investigated the effects of DCVC on cellular energy status and energy metabolism pathways in placental cells. Human extravillous trophoblast cells, HTR-8/SVneo, were exposed to 5-20 μM DCVC for 6 or 12 h. After establishing concentration and exposure duration thresholds for DCVC-induced cytotoxicity, targeted metabolomics was used to evaluate overall energy status and metabolite concentrations from energy metabolism pathways. The data revealed glucose metabolism perturbations including a time-dependent accumulation of glucose-6-phosphate+frutose-6-phosphate (G6P+F6P) as well as independent shunting of glucose intermediates that diminished with time, with modest energy status decline but in the absence of significant changes in ATP concentrations. Furthermore, metabolic profiling suggested that DCVC stimulated compensatory utilization of glycerol, lipid, and amino acid metabolism to provide intermediate substrates entering downstream in the glycolytic pathway or the tricarboxylic acid cycle. Lastly, amino acid deprivation increased susceptibility to DCVC-induced cytotoxicity. Taken together, these results suggest that DCVC caused metabolic perturbations necessitating adaptations in macronutrient and energy metabolism pathway utilization to maintain adequate ATP levels." @default.
• W3000269518 created "2020-01-23" @default.
• W3000269518 creator A5050297238 @default.
• W3000269518 creator A5055153306 @default.
• W3000269518 creator A5060849046 @default.
• W3000269518 creator A5090685901 @default.
• W3000269518 date "2020-01-17" @default.
• W3000269518 modified "2023-10-15" @default.
• W3000269518 title "Exposure to Trichloroethylene Metabolite <i>S</i>-(1,2-Dichlorovinyl)-L-cysteine Causes Compensatory Changes to Macronutrient Utilization and Energy Metabolism in Placental HTR-8/SVneo Cells" @default.
• W3000269518 cites W1489667102 @default.
• W3000269518 cites W1510025470 @default.
• W3000269518 cites W1536538430 @default.
• W3000269518 cites W1553155385 @default.
• W3000269518 cites W1566730133 @default.
• W3000269518 cites W1572658694 @default.
• W3000269518 cites W1606246362 @default.
• W3000269518 cites W1917495408 @default.
• W3000269518 cites W1964287021 @default.
• W3000269518 cites W1971915531 @default.
• W3000269518 cites W1978783736 @default.
• W3000269518 cites W1981622987 @default.
• W3000269518 cites W1984918145 @default.
• W3000269518 cites W1989943377 @default.
• W3000269518 cites W1991666948 @default.
• W3000269518 cites W1996592981 @default.
• W3000269518 cites W1997529430 @default.
• W3000269518 cites W2001490017 @default.
• W3000269518 cites W2002014230 @default.
• W3000269518 cites W2002528012 @default.
• W3000269518 cites W2009552705 @default.
• W3000269518 cites W2015980167 @default.
• W3000269518 cites W2018580834 @default.
• W3000269518 cites W2035347098 @default.
• W3000269518 cites W2037840343 @default.
• W3000269518 cites W2038768742 @default.
• W3000269518 cites W2039792651 @default.
• W3000269518 cites W2041342660 @default.
• W3000269518 cites W2042002086 @default.
• W3000269518 cites W2048755875 @default.
• W3000269518 cites W2058715094 @default.
• W3000269518 cites W2058784251 @default.
• W3000269518 cites W2065026248 @default.
• W3000269518 cites W2073130916 @default.
• W3000269518 cites W2074343850 @default.
• W3000269518 cites W2076794349 @default.
• W3000269518 cites W2079056593 @default.
• W3000269518 cites W2083941523 @default.
• W3000269518 cites W2084631767 @default.
• W3000269518 cites W2088063233 @default.
• W3000269518 cites W2091481684 @default.
• W3000269518 cites W2091822932 @default.
• W3000269518 cites W2094996169 @default.
• W3000269518 cites W2097275308 @default.
• W3000269518 cites W2104233489 @default.
• W3000269518 cites W2109132351 @default.
• W3000269518 cites W2111226392 @default.
• W3000269518 cites W2113400357 @default.
• W3000269518 cites W2114104841 @default.
• W3000269518 cites W2115042312 @default.
• W3000269518 cites W2118029488 @default.
• W3000269518 cites W2122546244 @default.
• W3000269518 cites W2134715197 @default.
• W3000269518 cites W2135578995 @default.
• W3000269518 cites W2149510745 @default.
• W3000269518 cites W2151499242 @default.
• W3000269518 cites W2155495720 @default.
• W3000269518 cites W2160782334 @default.
• W3000269518 cites W2168791593 @default.
• W3000269518 cites W2171765356 @default.
• W3000269518 cites W2293304001 @default.
• W3000269518 cites W2297906743 @default.
• W3000269518 cites W2301055642 @default.
• W3000269518 cites W2323026343 @default.
• W3000269518 cites W2464768860 @default.
• W3000269518 cites W2492203640 @default.
• W3000269518 cites W2529573043 @default.
• W3000269518 cites W2534782676 @default.
• W3000269518 cites W2560464336 @default.
• W3000269518 cites W2602019172 @default.
• W3000269518 cites W2767755936 @default.
• W3000269518 cites W2790749276 @default.
• W3000269518 cites W2804626200 @default.
• W3000269518 cites W2807586373 @default.
• W3000269518 cites W2905152537 @default.
• W3000269518 cites W2914253295 @default.
• W3000269518 cites W2942789806 @default.
• W3000269518 cites W2970311650 @default.
• W3000269518 cites W4210959301 @default.
• W3000269518 cites W4234905351 @default.
• W3000269518 cites W72352576 @default.
• W3000269518 cites W2009775788 @default.
• W3000269518 doi "https://doi.org/10.1021/acs.chemrestox.9b00356" @default.
• W3000269518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7299793" @default.
• W3000269518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31951115" @default.
• W3000269518 hasPublicationYear "2020" @default.
• W3000269518 type Work @default.
• W3000269518 sameAs 3000269518 @default.
• W3000269518 citedByCount "9" @default.

• next