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• W3000301398 startingPage "40" @default.
• W3000301398 abstract "Latent HIV reservoir is a major barrier to absolute HIV cure. Studies on latency reversal agents (LRA) have by far focused mainly on CD4+ T-lymphocytes, while myeloid reservoirs remain under-represented despite their persistence and key contribution to HIV pathogenesis. cAMP has been shown to increase HIV-1 transcription in latently-infected monocytes/macrophages. In this communication, we explored the potential of commercially available pharmacological drugs and phosphodiesterase inhibitors to reactivate HIV in latently-infected monocytic cell-line, U1. We showed that increased levels of intracellular cAMP reverse HIV latency in vitro, which is specific to cells of the myeloid lineage. High throughput RNA-seq analysis revealed that cAMP modulates transcriptional profile of latently HIV-infected cells and provides favourable cellular environment for HIV to produce viral proteins. This reactivation of latent HIV was inhibited by Mithramycin A, a selective Sp1 inhibitor, indicating that the reversal of HIV latency in monocytes is driven by transcription factor Sp1." @default.
• W3000301398 created "2020-01-23" @default.
• W3000301398 creator A5015175716 @default.
• W3000301398 creator A5023005377 @default.
• W3000301398 creator A5065045394 @default.
• W3000301398 creator A5086859980 @default.
• W3000301398 date "2020-03-01" @default.
• W3000301398 modified "2023-10-10" @default.
• W3000301398 title "Transcriptional profiling indicates cAMP-driven reversal of HIV latency in monocytes occurs via transcription factor SP-1" @default.
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